Results 11 to 20 of about 18,858 (196)
American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023 Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei +4 more
wiley +1 more source
BMJ Neurology Open, 2020 Background Evidence suggests that lamotrigine could be effective in reducing aura frequency and duration. However, studies comparing lamotrigine to other, first-line prophylactic agents solely involving patients suffering from migraine with aura are ...
Francesco Janes +3 more
doaj +1 more source
A Terbium Metal–Organic Framework Platform for Determination of Lamotrigine in Exhaled Breath Condensate [PDF]
Pharmaceutical Sciences, 2022 Background: Lamotrigine is widely used in the management of partial epilepsy, generalized tonic-clonic epilepsy and Lenox-Gastut syndrome and is an add-on therapy in the treatment of complex and simple partial seizures and secondarily generalized tonic ...
Parisa Eydi +4 more
doaj +1 more source
Lamotrigine Extraction and Quantification by UPLC-DAD in Plasma from Patients with Bipolar Disorder
International Journal of Analytical Chemistry, 2022 A sensitive and efficient analytical process for detecting lamotrigine in acidic solution based in ultra-high-performance liquid chromatography-diode array detector (UPLC-DAD) was developed; the stationary phase used was a C8, 150 × 4.6 mm, 2.6 µm.
Claudia V. Palacios-Magaña +5 more
doaj +1 more source
Toxicology Reports, 2021 Lamotrigine and levetiracetam are widely used second-generation anti-epileptic drugs. Existing literature indicates that overdose of either drug is typically benign, but neurologic and cardiac toxicity can occur in some cases. In this retrospective study,
Kelly E. Wood +2 more
doaj +1 more source
"A COMPARATIVE TRIAL OF LAMOTRIGINE AND CARBAMAZEPINE IN PATIENTS WITH PRIMARY GENERALIZED TONIC CLONIC SEIZURES" [PDF]
Acta Medica Iranica, 2004 Lamotrigine has been used widely in the treatment of partial and secondary generalized seizures. In this study use of lamotrigine as monotherapy for the newly diagnosed primary generalized tonic–clonic seizure has been investigated and compared with ...
H. Ghelichnia +1 more
doaj +2 more sources
Multi-Omics in Predicting Lamotrigine Neurotoxicity: Current Opportunities (Review)
Безопасность и риск фармакотерапии, 2022 INTRODUCTION. Lamotrigine (LTG) is among the most commonly prescribed second-generation antiepileptic drugs due to its low teratogenic risk. However, lamotrigine has pronounced neurotoxic, hepatotoxic, dermatotoxic potential (for genetic and metabolic ...
N. A. Shnayder +3 more
doaj +1 more source
Pharmaceuticals, 2022 Lamotrigine is widely prescribed to treat bipolar neurological disorder and epilepsy. It exerts its antiepileptic action by blocking voltage-gated sodium channels in neurons.
Juan Antonio Contreras Vite +4 more
doaj +1 more source
Pharmaceuticals, 2023 Intravenous (IV) ketamine and FDA-approved intranasal (IN) esketamine are increasingly used for treatment-resistant depression (TRD). Preliminary studies have suggested a synergistic effect of ketamine and lamotrigine, although the data are inconclusive.
Boney Joseph +13 more
doaj +1 more source
Discovery of a small molecule that inhibits bacterial ribosome biogenesis
eLife, 2014 While small molecule inhibitors of the bacterial ribosome have been instrumental in understanding protein translation, no such probes exist to study ribosome biogenesis.
Jonathan M Stokes +4 more
doaj +1 more source