Results 61 to 70 of about 18,858 (196)

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

A comparison before and after lamotrigine use in long term continuation treatment: effect of blood level

Psychiatry and Behavioral Sciences, 2013
Objective: The hypothesis of this study is that the efficacy of lamotrigine is related with blood level in bipolar disorder. Our aim is to compare the periods before and after lamotrigine use in cases with bipolar disorder and to investigate whether ...
Sermin Kesebir, Fisun Akdeniz, Aysun Demir, Mustafa Bilici   +3 more
doaj   +1 more source

Epileptic drop attacks: More than just atonic seizures

Epilepsia Open, EarlyView.
Abstract “Drop attacks” are not officially defined by the International League Against Epilepsy. Seizures are characterized by a sudden loss of control over the trunk and posture, leading to falls and injuries, and resolving within a few seconds. Accurately diagnosing the type of seizure is usually difficult due to limitations in clinical documentation
Tomonori Ono, Kazuaki Sato, Ryoko Honda, Hiroshi Otsubo   +3 more
wiley   +1 more source

Acute neural effects of the mood stabiliser lamotrigine on emotional processing in healthy volunteers: a randomised control trial

Translational Psychiatry
Lamotrigine is an effective mood stabiliser, largely used for the management and prevention of depression in bipolar disorder. The neuropsychological mechanisms by which lamotrigine acts to relieve symptoms as well as its neural effects on emotional ...
Marieke A. G. Martens, Tarek Zghoul, Evelyn Watson, Sebastian W. Rieger, Liliana P. Capitão, Catherine J. Harmer   +5 more
doaj   +1 more source

Comparison of the effectiveness, safety and tolerability of Perampanel and Levetiracetam as monotherapy in Chinese patients with focal‐onset seizures: A single‐center, ambispective, open‐label, real‐world observational study

Epilepsia Open, EarlyView.
Abstract Objective To compare the effectiveness and safety of Perampanel (PER) and Levetiracetam (LEV) as monotherapy in Chinese patients with focal‐onset seizures (FOS). Methods This is a single‐center, ambispective, open‐label, real‐world observational study.
Haiyan Ma, Rui Zhang, Yan Zhang, Honghao Xu, Xuefeng Qu, Yiqing Yang, Jiajia Li, Lu Yang, Qigang Zhou, Haitao Zhu   +9 more
wiley   +1 more source

A multi‐feature method for real‐time seizure detection in pediatric intensive care unit

Epilepsia Open, EarlyView.
Abstract Purpose Continuous electroencephalogram (cEEG) monitoring is an important technique used in detecting electroclinical seizures in the pediatric intensive care unit (PICU). This study developed an artificial intelligence method for the real‐time automatic detection of seizures in the PICU.
Tian Sang, Jiong Deng, Tong Zhao, Qi Zhang, Qiao Guan, Yanqin Lei, Yuxiang Yan, Bo Hong, Ningning Wei, Yuwu Jiang, Ying Wang   +10 more
wiley   +1 more source

Cardiac Electrophysiological Effects of the Sodium Channel-Blocking Antiepileptic Drugs Lamotrigine and Lacosamide

Pharmaceuticals
Background: The two antiepileptic drugs lacosamide and lamotrigine exert their antiepileptic effect by inhibiting sodium channels. Lacosamide enhances the inactivation of sodium channels, while lamotrigine inhibits the activation of the channel ...
Julian Wolfes, Philipp Achenbach, Felix K. Wegner, Benjamin Rath, Lars Eckardt, Gerrit Frommeyer, Christian Ellermann   +6 more
doaj   +1 more source

Failure of Ketamine Anesthesia in a Patient with Lamotrigine Overdose

Case Reports in Critical Care, 2014
Introduction. It is important to know which clinical situations prevent ketamine from working. Case Report. We present the case of the psychiatric inpatient who was admitted to our emergency department after ingesting a toxic dose of lamotrigine, unknown
Daniel Kornhall, Erik Waage Nielsen
doaj   +1 more source

Predictors of etiology and drug resistance in children with new‐onset focal seizures

Epilepsia Open, EarlyView.
Abstract Objective To examine the clinical features of new‐onset focal seizures in children and investigate clinical associations and predictors of underlying etiology and drug resistance. Methods Data were gathered from The Children's Hospital at Westmead admissions for patients aged 1 month to 18 years who presented with new‐onset focal seizures ...
Byoung Chan Lee, Russell C. Dale, Elizabeth H. Barnes, Shekeeb S. Mohammad, Sachin Gupta, Chong Wong, Deepak Gill, Kavitha Kothur   +7 more
wiley   +1 more source

In‐hospital outcomes of lacosamide versus levetiracetam for early adjunctive treatment of status epilepticus: A Nationwide Japanese retrospective cohort study

Epilepsia Open, EarlyView.
Abstract Objective Status epilepticus (SE) is a neurological emergency requiring immediate treatment. Although intravenous lacosamide (LCM) is used for the management of epilepsy, its effectiveness in treating SE remains unclear. We aimed to compare the in‐hospital outcomes between intravenous LCM and levetiracetam (LEV) as an early adjunctive therapy ...
Yumiko Nakamura, Shotaro Aso, Hideo Yasunaga, Hiroki Matsui, Yuichiro Shirota, Masashi Hamada, Kiyohide Fushimi, Tatsushi Toda, Satoshi Kodama   +8 more
wiley   +1 more source