Results 11 to 20 of about 21,208 (178)

Potential Involvement of Redox and Inflammatory Signalling in the Antihyperglycemic and Antioxidant Effects of Harmaline in Male Mice With Type 2 Diabetes. [PDF]

Endocrinol Diabetes Metab
HAR may improve T2DM by enhancing antioxidant defences through Nrf2 activation while suppressing inflammation and RAS activity, supporting its capability to treat diabetes. ABSTRACT Introduction Type 2 diabetes mellitus (T2DM) is strongly associated with oxidative stress and inflammation.
Malekinia F, Ahangarpour A, Hoseinynejad K, Mard SA, Radan M, Nejaddehbashi F.   +5 more
europepmc   +2 more sources

Differentiation of pancreatic endocrine islets in buffalo fetus

Indian Journal of Animal Sciences, 2020
Pancreas of 24 buffalo foetii collected from abattoir and veterinary clinics, GADVASU, Ludhiana were studied. The buffalo foetii were divided into three groups after measuring their CVRL, viz.
DIVYA GUPTA, VARINDER UPPAL, NEELAM BANSAL, ANURADHA GUPTA   +3 more
doaj   +1 more source

Multipotent mesenchymal stromal cells enhance insulin secretion from human islets via N-cadherin interaction and prolong function of transplanted encapsulated islets in mice

Stem Cell Research & Therapy, 2017
Background Multipotent mesenchymal stromal cells (MSC) enhance viability and function of islets of Langerhans. We aimed to examine the interactions between human MSC and human islets of Langerhans that influence the function of islets.
Elisa Montanari, Raphael P. H. Meier, Redouan Mahou, Jörg D. Seebach, Christine Wandrey, Sandrine Gerber-Lemaire, Leo H. Buhler, Carmen Gonelle-Gispert   +7 more
doaj   +1 more source

Transplante isogênico de ilhotas de Langerhans no fígado de ratos: metodologia para separação e purificação das ilhotas de Langerhans Isogenic islet transplantation on the rat liver: Method for isolation and purification of the rat islets

Arquivos de Gastroenterologia, 2000
A maior indicação do transplante de pâncreas ou de ilhotas de Langerhans é o diabetes mellitus do tipo I. O processo deve suprir as necessidades de insulina mantendo os níveis glicêmicos dentro da normalidade.
Eleazar CHAIB, Apostolos PAPALOIS, Ingrid G. M. BRONS, Roy Y. CALNE   +3 more
doaj   +1 more source

The pancreatic islet: a micro-organ in control [PDF]

CellR4, 2021
The islets of Langerhans constitute the endocrine pancreas which regulates blood glucose homeostasis and islet dysfunction results in diabetes. Each of the pancreatic islets constitutes an entire micro-organ with intricate cell to cell interactions and ...
M. Abdulreda, P. Berggren
doaj   +1 more source

d-Sorbose Promotes Regulatory T-Cell Differentiation and Ameliorates Autoimmune and Allergic Diseases via Hexosamine Biosynthetic Pathway Inhibition. [PDF]

FASEB J
d‐Sorbose promotes Foxp3+ Treg differentiation ex vivo and exerts potent anti‐inflammatory effects in vivo, ameliorating allergic airway inflammation and preventing autoimmune diabetes without compromising T cell viability or inducing toxicity.
Sato F, Hoshi M, Yokoi H, Yoshida S, Takenaka R, Shimoga N, Morita N, Tashita C, Yamazaki K, Kishimoto Y, Tezuka H, Ito H, Saito K.   +12 more
europepmc   +2 more sources

Crocin Protects Mice Pancreatic Islets from Oxidative Stress Induced by Methylglyoxal and Increases Insulin Secretion

Düzce Tıp Fakültesi Dergisi, 2023
Aim: Islets of Langerhans are more sensitive to oxidative damage because of their low antioxidant capacity. In diabetes, methylglyoxal (MG) accumulates in the pancreas.
Akram Ahangarpour, Reza Noeı Razlıqı, Elnaz Haroonı, Vahid Radmehr   +3 more
doaj   +1 more source

Insulin Treatment of Mice Recipients Preserves β-Cell Function in Porcine Islet Transplantation

Cell Transplantation, 2002
Encapsulation of islets of Langerhans confers protection against cell-mediated immune destruction and so should allow the transplantation of islets without immunosuppression.
Oleg Pakhomov, Jiry Honiger, Edouard Gouin, Roland Cariolet, Gerard Reach, Sylviane Darquy Ph.D.   +5 more
doaj   +1 more source

Antioxidant Effects of Eugenol on Oxidative Stress Induced by Hydrogen Peroxide in Islets of Langerhans Isolated from Male Mouse

International Journal of Hepatology, 2020
Background. The antioxidant system in islets of Langerhans is weak, which can lead to diabetes. Meanwhile, the main component of cloves that produce antioxidant effects is eugenol.
Ali Akbar Oroojan, Narges Chenani, Marzieh An’aam   +2 more
doaj   +1 more source

Azelaic acid reduces arsenic-induced toxicity and inflammation in the rat islets of langerhans [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Arsenic is classified as a toxic metal that is naturally found in the Earth’s crust, and long-term exposure to it can result in chronic human disorders like cancer and diabetes.
Sara Mostafalou, Fatemeh Moafi-Madani, Maryam Baeeri, Mahban Rahimifard, Hamed Haghi-Aminjan   +4 more
doaj   +1 more source