Recognition of Staphylococcus aureus by the pattern recognition molecules langerin, mannan-binding lectin, and surfactant protein D: the influence of capsular polysaccharides and wall teichoic acid [PDF]
Frontiers in ImmunologyThe innate immune system plays a critical role in the rapid recognition and elimination of pathogens through pattern recognition receptors (PRRs). Among these PRRs are the C-type lectins (CTLs) langerin, mannan-binding lectin (MBL), and surfactant ...
Kirstine Mejlstrup Hymøller +8 more
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Targeting human langerin promotes HIV-1 specific humoral immune responses.
PLoS Pathogens, 2021 The main avenue for the development of an HIV-1 vaccine remains the induction of protective antibodies. A rationale approach is to target antigen to specific receptors on dendritic cells (DC) via fused monoclonal antibodies (mAb).
Jérôme Kervevan +22 more
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Corrigendum: Recognition of Staphylococcus aureus by the pattern recognition molecules langerin, mannan-binding lectin, and surfactant protein D: the influence of capsular polysaccharides and wall teichoic acid [PDF]
Frontiers in ImmunologyKirstine Mejlstrup Hymøller +8 more
doaj +3 more sources
Genetic characterisation of Langerin gene in human immunodeficiency virus-1-infected women from Bahia, Brazil [PDF]
Memorias do Instituto Oswaldo Cruz, 2014 Studies on human genetic variations are a useful source of knowledge about human immunodeficiency virus (HIV)-1 infection. The Langerin protein, found at the surface of Langerhans cells, has an important protective role in HIV-1 infection. Differences in
Giselle Calasans de Souza Costa +6 more
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Computational and experimental prediction of human C-type lectin receptor druggability [PDF]
Frontiers in Immunology, 2014 Mammalian C-type lectin receptors are involved in many aspects of immune cell regulation such as pathogen recognition, clearance of apoptotic bodies and lymphocyte homing.
Jonas eAretz +8 more
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Langerin-Heparin Interaction: Two Binding Sites for Small and Large Ligands as revealed by a combination of NMR Spectroscopy and Cross-Linking Mapping Experiments [PDF]
, 2015 Langerin is a C-type lectin present on Langerhans cells that mediates capture of pathogens in a carbohydrate-dependent manner, leading to subsequent internalization and elimination in the cellular organelles called Birbeck granules.
Angulo, Jesus +9 more
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CD11b+ migratory dendritic cells mediate CD8 T cell cross-priming and cutaneous imprinting after topical immunization. [PDF]
PLoS ONE, 2014 Topical antigen application is a focus of current vaccine research. This immunization route mimics natural antigen exposure across a barrier tissue and generates T cells imprinted for skin-selective homing.
Suzanne T Nizza, James J Campbell
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Birbeck granule-like "organized smooth endoplasmic reticulum" resulting from the expression of a cytoplasmic YFP-tagged langerin. [PDF]
PLoS ONE, 2013 Langerin is required for the biogenesis of Birbeck granules (BGs), the characteristic organelles of Langerhans cells. We previously used a Langerin-YFP fusion protein having a C-terminal luminal YFP tag to dynamically decipher the molecular and cellular ...
Cédric Lenormand +14 more
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Folia Histochemica et Cytobiologica, 2007 Langerhans cell histiocytoses (LCH) represent rare diseases of unclear etiology and pathogenesis. Most of the cases include children, 1 to 15 years of age, and various organs are involved (bones, skin, liver, lymph nodes, bone marrow and other).
Marzena Podhorska-Okołów +8 more
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RARα supports the development of Langerhans cells and langerin-expressing conventional dendritic cells [PDF]
Nature Communications, 2018 Langerhans cells (LC) and langerin-expressing conventional dendritic cells are made from distinct progenitors and enriched in the distinct microenvironments of the skin.
Seika Hashimoto-Hill +5 more
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