Calcium Competitive Inhibition of Langerin by Thiazolopyrimidinones. [PDF]
J Med ChemRaw data associated with Ning Y. et al. 2025 J Med Chem.
Ning Y +13 more
europepmc +8 more sources
Recognition of Staphylococcus aureus by the pattern recognition molecules langerin, mannan-binding lectin, and surfactant protein D: the influence of capsular polysaccharides and wall teichoic acid [PDF]
Frontiers in ImmunologyThe innate immune system plays a critical role in the rapid recognition and elimination of pathogens through pattern recognition receptors (PRRs). Among these PRRs are the C-type lectins (CTLs) langerin, mannan-binding lectin (MBL), and surfactant ...
Kirstine Mejlstrup Hymøller +8 more
doaj +4 more sources
Cryo-electron tomography of Birbeck granules reveals the molecular mechanism of langerin lattice formation [PDF]
eLife, 2022 Langerhans cells are specialized antigen-presenting cells localized within the epidermis and mucosal epithelium. Upon contact with Langerhans cells, pathogens are captured by the C-type lectin langerin and internalized into a structurally unique vesicle ...
Toshiyuki Oda +4 more
doaj +2 more sources
Frontiers in Immunology, 2022 Cutaneous dendritic cells (DCs) have been implicated in the pathogenesis of atopic dermatitis (AD). However, the specific role of different subsets of DCs has not been well defined.
Chunying Xiao +10 more
doaj +2 more sources
Computational and experimental prediction of human C-type lectin receptor druggability [PDF]
Frontiers in Immunology, 2014 Mammalian C-type lectin receptors are involved in many aspects of immune cell regulation such as pathogen recognition, clearance of apoptotic bodies and lymphocyte homing.
Jonas eAretz +8 more
doaj +3 more sources
CD11b+ migratory dendritic cells mediate CD8 T cell cross-priming and cutaneous imprinting after topical immunization. [PDF]
PLoS ONE, 2014 Topical antigen application is a focus of current vaccine research. This immunization route mimics natural antigen exposure across a barrier tissue and generates T cells imprinted for skin-selective homing.
Suzanne T Nizza, James J Campbell
doaj +6 more sources
Langerhans Cells Sense
mBio, 2019 Staphylococcus aureus is a major cause of skin and soft tissue infections and aggravator of the inflammatory skin disease atopic dermatitis (AD [eczema]). Epicutaneous exposure to S.
Rob van Dalen +12 more
doaj +2 more sources
Langerin-Heparin Interaction: Two Binding Sites for Small and Large Ligands as revealed by a combination of NMR Spectroscopy and Cross-Linking Mapping Experiments [PDF]
, 2015 Langerin is a C-type lectin present on Langerhans cells that mediates capture of pathogens in a carbohydrate-dependent manner, leading to subsequent internalization and elimination in the cellular organelles called Birbeck granules.
Angulo, Jesus +9 more
core +9 more sources
Murine Langerin+ dermal dendritic cells prime CD8+ T cells while Langerhans cells induce cross‐tolerance [PDF]
EMBO Molecular Medicine, 2014 Skin dendritic cells (DCs) control the immunogenicity of cutaneously administered vaccines. Antigens targeted to DCs via the C‐type lectin Langerin/CD207 are cross‐presented to CD8+ T cells in vivo. We investigated the relative roles of Langerhans cells (
Vincent Flacher +6 more
doaj +2 more sources
Langerhans Cells: Sensing the Environment in Health and Disease [PDF]
Frontiers in Immunology, 2018 In the last few decades, our understanding of Langerhans cells (LCs) has drastically changed based on novel findings regarding the developmental origin and biological functions of these epidermis-specific resident immune cells.
Julie Deckers +5 more
doaj +3 more sources