Results 11 to 20 of about 8,574 (229)

Langerin-expressing dendritic cells in pulmonary immune-related diseases

Frontiers in Medicine, 2022
Dendritic cells (DCs) are “frontline” immune cells dedicated to antigen presentation. They serve as an important bridge connecting innate and adaptive immunity, and express various receptors for antigen capture.
Shurui Xuan, Yuebei Li, Yunhui Wu, Ian M. Adcock, Xiaoning Zeng, Xin Yao   +5 more
doaj   +5 more sources

Common Polymorphisms in Human Langerin Change Specificity for Glycan Ligands [PDF]

Journal of Biological Chemistry, 2013
Langerin, a C-type lectin on Langerhans cells, mediates carbohydrate-dependent uptake of pathogens in the first step of antigen presentation to the adaptive immune system. Langerin binds a diverse range of carbohydrates including high mannose structures,
Drickamer, K, Feinberg, H, Rowntree, TJW, Tan, SLW, Taylor, ME, Weis, WI   +5 more
core   +6 more sources

Targeting human langerin promotes HIV-1 specific humoral immune responses.

PLoS Pathogens, 2021
The main avenue for the development of an HIV-1 vaccine remains the induction of protective antibodies. A rationale approach is to target antigen to specific receptors on dendritic cells (DC) via fused monoclonal antibodies (mAb).
Jérôme Kervevan, Aurélie Bouteau, Juliane S Lanza, Adele Hammoudi, Sandra Zurawski, Mathieu Surenaud, Lydie Dieudonné, Marion Bonnet, Cécile Lefebvre, Hakim Hocini, Romain Marlin, Aurélie Guguin, Barbara Hersant, Oana Hermeziu, Elisabeth Menu, Christine Lacabaratz, Jean-Daniel Lelièvre, Gerard Zurawski, Véronique Godot, Sandrine Henri, Botond Z Igyártó, Yves Levy, Sylvain Cardinaud   +22 more
doaj   +5 more sources

Targeting Langerhans cells via skin delivery of HIV Envelope enhances the antibody response to vaccination [PDF]

npj Vaccines
Targeting dendritic cells (DCs) with antigens is a promising approach to modulating T follicular helper (Tfh) cells and germinal center (GC) reactions, enhancing vaccine-induced adaptive immune responses, with preclinical studies highlighting a key role ...
Juliane S. Lanza, Adele Hammoudi, Joanna De Chiara, Mathieu Surenaud, Anaïs Kembou, Michela Esposito, Sandra Zurawski, Gerard Zurawski, Mireille Centlivre, Bernard Malissen, Véronique Godot, Yves Lévy, Sandrine Henri, Sylvain Cardinaud   +13 more
doaj   +2 more sources

RARα supports the development of Langerhans cells and langerin-expressing conventional dendritic cells [PDF]

Nature Communications, 2018
Langerhans cells (LC) and langerin-expressing conventional dendritic cells are made from distinct progenitors and enriched in the distinct microenvironments of the skin.
Seika Hashimoto-Hill, Leon Friesen, Sungtae Park, Suji Im, Mark H. Kaplan, Chang H. Kim   +5 more
doaj   +2 more sources

Langerin+CD8+ Dendritic Cells in the Splenic Marginal Zone: Not So Marginal After All [PDF]

Frontiers in Immunology, 2019
Dendritic cells (DC) fulfill an essential sentinel function within the immune system, acting at the interface of innate and adaptive immunity. The DC family, both in mouse and man, shows high functional heterogeneity in order to orchestrate immune ...
Ronald A. Backer, Nathalie Diener, Björn E. Clausen   +2 more
doaj   +2 more sources

Molecular mechanism of the pH-dependent calcium affinity in langerin [PDF]

, 2020
AbstractThe C-type lectin receptor langerin plays a vital role in the mammalian defense against invading pathogens. Its function hinges on the affinity to its co-factor Ca2+which in turn is regulated by the pH. We studied the structural consequences of protonating the allosteric pH-sensor histidine H294 by molecular dynamics simulations (total ...
Jan-Oliver Kapp-Joswig, Jennifer Anders, Hengxi Zhang, Christoph Rademacher, Bettina G. Keller   +4 more
openalex   +2 more sources

Detection of intraepithelial and stromal Langerin and CCR5 positive cells in the human endometrium: potential targets for HIV infection. [PDF]

PLoS ONE, 2011
Both the upper (endocervix and uterus) and lower (ectocervix and vagina) female genital tract mucosa are considered to be target sites for sexual transmission of HIV. There are a few reports on the T cell and antigen-presenting cell distribution in human
Tove Kaldensjö, Pernilla Petersson, Anna Tolf, Gareth Morgan, Kristina Broliden, Taha Hirbod   +5 more
doaj   +3 more sources

A Specific, Glycomimetic Langerin Ligand for Human Langerhans Cell Targeting [PDF]

ACS Central Science, 2019
Langerhans cells are a subset of dendritic cells residing in the epidermis of the human skin. As such, they are key mediators of immune regulation and have emerged as prime targets for novel transcutaneous cancer vaccines. Importantly, the induction of protective T cell immunity by these vaccines requires the efficient and specific delivery of both ...
Eike‐Christian Wamhoff, Jessica Schulze, Lydia Bellmann, Mareike Rentzsch, Gunnar Bachem, Felix F. Fuchsberger, Juliane Rademacher, Martin Hermann, Barbara Del Frari, Rob van Dalen, David J. Hartmann, Nina M. van Sorge, Oliver Seitz, Patrizia Stoitzner, Christoph Rademacher   +14 more
openalex   +7 more sources

Ontogeny of Langerin/CD207 Expression in the Epidermis of Mice [PDF]

Journal of Investigative Dermatology, 2004
C-type lectin receptors help Langerhans cells (LC) to take up and process pathogens. Langerin/CD207 is a mannose-binding C-type lectin that is specifically expressed by LC. It is involved in antigen uptake in an as yet poorly defined way, and it is a major molecular constituent of Birbeck granules.
Christoph H. Tripp, Souyet Chang‐Rodriguez, Patrizia Stoitzner, Sandra Holzmann, Hella Stössel, Patrice Douillard, Sem Saeland, Franz Koch, Adelheid Elbe‐Bürger, Nikolaus Romani   +9 more
openalex   +3 more sources