Results 11 to 20 of about 8,307 (232)

Langerin-expressing dendritic cells in pulmonary immune-related diseases

Frontiers in Medicine, 2022
Dendritic cells (DCs) are “frontline” immune cells dedicated to antigen presentation. They serve as an important bridge connecting innate and adaptive immunity, and express various receptors for antigen capture.
Shurui Xuan, Yuebei Li, Yunhui Wu, Ian M. Adcock, Xiaoning Zeng, Xin Yao   +5 more
doaj   +5 more sources

Common Polymorphisms in Human Langerin Change Specificity for Glycan Ligands [PDF]

Journal of Biological Chemistry, 2013
Langerin, a C-type lectin on Langerhans cells, mediates carbohydrate-dependent uptake of pathogens in the first step of antigen presentation to the adaptive immune system. Langerin binds a diverse range of carbohydrates including high mannose structures,
Drickamer, K, Feinberg, H, Rowntree, TJW, Tan, SLW, Taylor, ME, Weis, WI   +5 more
core   +6 more sources

Langerhans Cells: Sensing the Environment in Health and Disease [PDF]

Frontiers in Immunology, 2018
In the last few decades, our understanding of Langerhans cells (LCs) has drastically changed based on novel findings regarding the developmental origin and biological functions of these epidermis-specific resident immune cells.
Julie Deckers, Julie Deckers, Hamida Hammad, Hamida Hammad, Esther Hoste, Esther Hoste   +5 more
doaj   +3 more sources

Host Langerin (CD207) is a receptor for Yersinia pestis phagocytosis and promotes dissemination [PDF]

Immunology & Cell Biology, 2015
Yersinia pestis is a Gram-negative bacterium that causes plague. After Y. pestis overcomes the skin barrier, it encounters antigen-presenting cells (APCs), such as Langerhans and dendritic cells.
Anyi Li, Chae G Park, Cheolho Cheong, Gottfried RS., Gregory V Plano, Honghui Ding, Hongping Huang, John D Klena, Kun Yang, Lianxu Xia, Lin Zhang, Lingyu Jiang, Mikael Skurnik, Pei Zhang, Sara S Bartra, Shaogang Wang, Shusheng Zhang, Silvia Bulgheresi, Tie Chen, Yingxia He, Yiping Wu   +20 more
core   +5 more sources

Targeting Langerhans cells via skin delivery of HIV Envelope enhances the antibody response to vaccination [PDF]

npj Vaccines
Targeting dendritic cells (DCs) with antigens is a promising approach to modulating T follicular helper (Tfh) cells and germinal center (GC) reactions, enhancing vaccine-induced adaptive immune responses, with preclinical studies highlighting a key role ...
Juliane S. Lanza, Adele Hammoudi, Joanna De Chiara, Mathieu Surenaud, Anaïs Kembou, Michela Esposito, Sandra Zurawski, Gerard Zurawski, Mireille Centlivre, Bernard Malissen, Véronique Godot, Yves Lévy, Sandrine Henri, Sylvain Cardinaud   +13 more
doaj   +2 more sources

A population of Langerin-positive dendritic cells in murine Peyer's patches involved in sampling β-glucan microparticles. [PDF]

PLoS ONE, 2014
Glucan particles (GPs) are 2-4 μm hollow, porous shells composed of 1,3-β-D-glucan that have been effectively used for oral targeted-delivery of a wide range of payloads, including small molecules, siRNA, DNA, and protein antigens.
Magdia De Jesus, Gary R Ostroff, Stuart M Levitz, Toni R Bartling, Nicholas J Mantis   +4 more
doaj   +3 more sources

Functional Redundancy of Langerhans Cells and Langerin+ Dermal Dendritic Cells in Contact Hypersensitivity [PDF]

Journal of Investigative Dermatology, 2010
The relative roles of Langerhans cells (LC), dermal dendritic cells (DC), and, in particular, the recently discovered Langerin(+) dermal DC subset in the induction and control of contact hypersensitivity (CHS) responses remain controversial. Using an inducible mouse model, in which LC and other Langerin(+) DC can be depleted by injection of diphtheria ...
Madelon Noordegraaf, Vincent Flacher, Patrizia Stoitzner, Björn E. Clausen   +3 more
openalex   +5 more sources

Pyodermatitis-Pyostomatitis Vegetans: The Role of Langerin Deficiency in Disease Pathogenesis. [PDF]

J Clin Med
Pan D, Wang J, Cai L, Huang M, Han Q, Zheng Z, Zeng X, Chen Q, Ai R, Zhou Y.   +9 more
europepmc   +2 more sources

Unraveling cutaneous histiocytosis: insights into histology, pathogenesis, diagnosis, and treatment pitfalls [PDF]

Frontiers in Medicine
Histiocytoses represent a group of diverse rare disorders characterized by the abnormal accumulation of cells derived from the mononuclear phagocyte system in various tissues and organs.
Lucian G. Scurtu, Lucian G. Scurtu, Francesca Scurtu, Francesca Scurtu, Olga Simionescu, Olga Simionescu   +5 more
doaj   +2 more sources

Ontogeny of Langerin/CD207 Expression in the Epidermis of Mice [PDF]

Journal of Investigative Dermatology, 2004
C-type lectin receptors help Langerhans cells (LC) to take up and process pathogens. Langerin/CD207 is a mannose-binding C-type lectin that is specifically expressed by LC. It is involved in antigen uptake in an as yet poorly defined way, and it is a major molecular constituent of Birbeck granules.
Christoph H. Tripp, Souyet Chang‐Rodriguez, Patrizia Stoitzner, Sandra Holzmann, Hella Stössel, Patrice Douillard, Sem Saeland, Franz Koch, Adelheid Elbe‐Bürger, Nikolaus Romani   +9 more
openalex   +4 more sources