Results 21 to 30 of about 8,574 (229)

Rational Design of a DNA‐Scaffolded High‐Affinity Binder for Langerin [PDF]

Angewandte Chemie International Edition, 2020
AbstractBinders of langerin could target vaccines to Langerhans cells for improved therapeutic effect. Since langerin has low affinity for monovalent glycan ligands, highly multivalent presentation has previously been key for targeting. Aiming to reduce the amount of ligand required, we rationally designed molecularly defined high‐affinity binders ...
Gunnar Bachem, Eike‐Christian Wamhoff, Kim Silberreis, Dongyoon Kim, Hannes Baukmann, Felix F. Fuchsberger, Jens Dernedde, Christoph Rademacher, Oliver Seitz   +8 more
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Editorial: Faux amis: Langerin-expressing DC in humans and mice [PDF]

Journal of Leukocyte Biology, 2015
Discussion on the identification of Langerin+ DC populations in humans.
Clare L. Bennett
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A specific, glycomimetic Langerin ligand for human Langerhans cell targeting [PDF]

, 2018
AbstractLangerhans cells are a subset of dendritic cells residing in the epidermis of the human skin. As such, they are key mediators of immune regulation and have emerged as prime targets for novel transcutaneous cancer vaccines. Importantly, the induction of protective T cell immunity by these vaccines requires the efficient and specific delivery of ...
Eike‐Christian Wamhoff, Jessica Schulze, Lydia Bellmann, Gunnar Bachem, Felix F. Fuchsberger, Juliane Rademacher, Martin Hermann, Barbara Del Frari, Rob van Dalen, David J. Hartmann, Nina M. van Sorge, Oliver Seitz, Patrizia Stoitzner, Christoph Rademacher   +13 more
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Identification of a novel population of Langerin+ dendritic cells [PDF]

The Journal of Experimental Medicine, 2007
Langerhans cells (LCs) are antigen-presenting cells that reside in the epidermis of the skin and traffic to lymph nodes (LNs). The general role of these cells in skin immune responses is not clear because distinct models of LC depletion resulted in opposite conclusions about their role in contact hypersensitivity (CHS) responses.
Laura S. Bursch, Liang‐Chun Wang, Botond Z. Igyártó, Adrien Kissenpfennig, Bernard Malissen, Daniel H. Kaplan, Kristin A. Hogquist   +6 more
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Sphingosine 1-phosphate modulates antigen capture by murine langerhans cells via the S1P2 receptor subtype [PDF]

, 2012
Dendritic cells (DCs) play a pivotal role in the development of cutaneous contact hypersensitivity (CHS) and atopic dermatitis as they capture and process antigen and present it to T lymphocytes in the lymphoid organs.
A Kihara, A Kissenpfennig, A Kumar, A Martino, A Olivera, A Weigert, AD Christensen, Burkhard Kleuser, C Ocana-Morgner, C Ruedl, CC Norbury, CL Bennett, CL Bennett, DH Kaplan, DH Kaplan, E Guaguere, ES Trombetta, EY Seo, F Sparber, G Gollmann, G Schuhmachers, H Hackstein, H Liu, Heinfried H. Radeke, HH Radeke, I Reines, J Chun, Jagadeesh Bayry, JH Hong, K Kabashima, K Sarkar, K Takabe, Katrin Schaper, L Japtok, L Rose, L Ruwisch, LS Bursch, Lukasz Japtok, M Hara-Chikuma, M Matloubian, M Schröder, M Schuppel, MB Lutz, MC Kerr, ML Allende, ML Allende, N Romani, P Mitra, P Monti, R van de Ven, RH Kim, RM Steinman, S Spiegel, S Sullivan, S Xu, Se Kyoo Jeong, SH Wood, SP Zahner, T Hla, T Kitajima, T Walzer, V Brinkmann, W Baumer, W Baumer, W Baumer, Wolfgang Bäumer, Y Maeda, Y Yanagawa, YY Lan   +68 more
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Depletion of langerin⁺ cells enhances cutaneous wound healing [PDF]

Immunology, 2020
SummaryLangerin is a C‐type lectin receptor that is expressed on Langerhans cells and langerin‐positive dermal dendritic cells in the skin. Little is known about the function of langerin+ cells in wound healing. In this study, the effects of ablation of langerin+ cells on healing of a full‐thickness excision wound were investigated using the langerin ...
Aarthi Rajesh, Gabriella S. Stuart, Nicola C. Real, Jenny Ahn, Allison Tschirley, Lyn M. Wise, Merilyn Hibma   +6 more
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Corrigendum: Recognition of Staphylococcus aureus by the pattern recognition molecules langerin, mannan-binding lectin, and surfactant protein D: the influence of capsular polysaccharides and wall teichoic acid [PDF]

Frontiers in Immunology
Kirstine Mejlstrup Hymøller, Kirstine Mejlstrup Hymøller, Stig Hill Christiansen, Stig Hill Christiansen, Anders Grønnegaard Schlosser, Uffe B. Skov Sørensen, Jean C. Lee, Steffen Thiel, Steffen Thiel   +8 more
doaj   +2 more sources

Peritumoural and Intratumoural Distribution of Langerhan Cell in Oral Squamous Cell Carcinoma and its Association with Known Prognostic Factors [PDF]

Journal of Clinical and Diagnostic Research, 2023
Introduction: Oral Squamous Cell Carcinoma (OSCC) accounts for about 2/3rd of the Head and Neck Squamous Cell Carcinomas (HNSCC). It is the sixth most common cancer worldwide and the third most common cancer in developing countries including India.
Sandhra Papparath Usman, Deepti Ramakrishnan, S Divya   +2 more
doaj   +1 more source

Glycosaminoglycans are interactants of Langerin: comparison with gp120 highlights an unexpected calcium-independent binding mode. [PDF]

PLoS ONE, 2012
Langerin is a C-type lectin specifically expressed in Langerhans cells. As recently shown for HIV, Langerin is thought to capture pathogens and mediate their internalisation into Birbeck Granules for elimination.
Eric Chabrol, Alessandra Nurisso, Antoine Daina, Emilie Vassal-Stermann, Michel Thepaut, Eric Girard, Romain R Vivès, Franck Fieschi   +7 more
doaj   +1 more source

Langerin (CD207) represents a novel interferon-stimulated gene in Langerhans cells [PDF]

Cellular & Molecular Immunology, 2019
Interferons (IFNs) are “warning signal” cytokines released upon pathogen sensing. IFNs control the expression of interferon-stimulated genes (ISGs), which are often crucial to restrict viral infections and establish a cellular antiviral state.1,2 Langerin (CD207), a well-known surface receptor on Langerhans cells (LC), belongs to the C-type lectin ...
Ghizlane Maarifi, Magdalena A. Czubala, Justine Lagisquet, Matthew O. Ivory, Kyra J. Fuchs, Laure Papin, James C. Birchall, Sébastien Nisole, Vincent Piguet, Fabien P. Blanchet   +9 more
openalex   +3 more sources