Results 21 to 30 of about 8,307 (232)
Identification of a novel population of Langerin+ dendritic cells [PDF]
The Journal of Experimental Medicine, 2007 Langerhans cells (LCs) are antigen-presenting cells that reside in the epidermis of the skin and traffic to lymph nodes (LNs). The general role of these cells in skin immune responses is not clear because distinct models of LC depletion resulted in opposite conclusions about their role in contact hypersensitivity (CHS) responses.
Laura S. Bursch +6 more
openalex +6 more sources
An Unusual Case of Cutaneous Langerhans Cell Sarcoma Lacking S100 Expression: A Case Report and Review of the Literature. [PDF]
J Cutan PatholABSTRACT Langerhans cell sarcoma (LCS) is a rare neoplastic proliferation of Langerhans cell with aggressive clinical behavior and involves multiple organ systems, including the skin. LCS is characterized by marked cytologic atypia, frequent mitoses including atypical ones, and expression of CD1a, S100, and langerin (CD207).
Obid R +8 more
europepmc +2 more sources
Trimeric Structure of Langerin [PDF]
Journal of Biological Chemistry, 2010 Langerin, an endocytic receptor of Langerhans cells, binds pathogens such as human immunodeficiency virus by recognition of surface glycoconjugates and mediates their internalization into Birbeck granules. Langerin has an extracellular region consisting of a C-type carbohydrate-recognition domain (CRD) and a neck region that stabilizes formation of ...
H. Feinberg +3 more
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Bilateral Spontaneous Pneumothorax in a Young Gentleman. [PDF]
Respirol Case RepWe present a case of bilateral spontaneous pneumothorax in a 26‐year‐old Chinese male with a history of smoking. Imaging reveals the presence of underlying cystic lung disease and he subsequently underwent bilateral video‐assisted thoracoscopic surgery (VATS) bullectomy, mechanical pleurodesis, and surgical lung biopsy.
Teng A, Chua TH, Chow CY, Tan YH.
europepmc +2 more sources
Calcium‐Independent Activation of an Allosteric Network in Langerin by Heparin Oligosaccharides [PDF]
ChemBioChem, 2017 AbstractThe C‐type lectin receptor Langerin is a glycan‐binding protein that serves as an uptake receptor on Langerhans cells and is essential for the formation of Birbeck granules. Whereas most Langerin ligands are recognized by a canonical Ca2+‐dependent binding site, heparins have been proposed to make additional contacts to a secondary, Ca2 ...
Jonas Hanske +7 more
openalex +4 more sources
A Liposomal Platform for Delivery of a Protein Antigen to Langerin-Expressing Cells [PDF]
Biochemistry, 2019 The skin is an attractive site for vaccination and harbors a dense network of Langerhans cells that are the prime target for antigen delivery approaches in the epidermis. While specific targeting of Langerhans cells has been shown to elicit the necessary T-cell response using antibody-based delivery approaches, the targeted administration of ...
Jessica Schulze +5 more
openalex +5 more sources
Skin TLR7 triggering promotes accumulation of respiratory dendritic cells and natural killer cells. [PDF]
, 2012 The TLR7 agonist imiquimod has been used successfully as adjuvant for skin treatment of virus-associated warts and basal cell carcinoma. The effects of skin TLR7 triggering on respiratory leukocyte populations are unknown.
Baal, Nelli +9 more
core +13 more sources
Polymorphisms in Human Langerin Affect Stability and Sugar Binding Activity [PDF]
Journal of Biological Chemistry, 2006 Langerhans cells are specialized skin dendritic cells that take up and degrade antigens for presentation to the immune system. Langerin, a cell surface C-type lectin of Langerhans cells, can be internalized and accumulates in Birbeck granules, subdomains of the endosomal recycling compartment that are specific to Langerhans cells.
Eliot M. Ward +3 more
openalex +5 more sources
CD1a and langerin: acting as more than Langerhans cell markers [PDF]
Journal of Clinical Investigation, 2004 Langerhans cells (LCs) represent a unique DC subset populating the outermost body surface, i.e., the epidermis. Although CD1a and langerin (CD207) are used as specific markers to distinguish LCs from other DC subsets, their immunological functions have remained mostly unknown.
Norikatsu Mizumoto, Akira Takashima
openalex +4 more sources
Frontiers in Immunology, 2022 Cutaneous dendritic cells (DCs) have been implicated in the pathogenesis of atopic dermatitis (AD). However, the specific role of different subsets of DCs has not been well defined.
Chunying Xiao +10 more
doaj +1 more source