Results 31 to 40 of about 8,574 (229)

Trimeric Structure of Langerin [PDF]

Journal of Biological Chemistry, 2010
Langerin, an endocytic receptor of Langerhans cells, binds pathogens such as human immunodeficiency virus by recognition of surface glycoconjugates and mediates their internalization into Birbeck granules. Langerin has an extracellular region consisting of a C-type carbohydrate-recognition domain (CRD) and a neck region that stabilizes formation of ...
Feinberg, H, Powlesland, AS, Taylor, ME, Weis, WI   +3 more
openaire   +4 more sources

Birbeck granule-like "organized smooth endoplasmic reticulum" resulting from the expression of a cytoplasmic YFP-tagged langerin. [PDF]

PLoS ONE, 2013
Langerin is required for the biogenesis of Birbeck granules (BGs), the characteristic organelles of Langerhans cells. We previously used a Langerin-YFP fusion protein having a C-terminal luminal YFP tag to dynamically decipher the molecular and cellular ...
Cédric Lenormand, Coralie Spiegelhalter, Bertrand Cinquin, Sabine Bardin, Huguette Bausinger, Catherine Angénieux, Anita Eckly, Fabienne Proamer, David Wall, Ben Lich, Sylvie Tourne, Daniel Hanau, Yannick Schwab, Jean Salamero, Henri de la Salle   +14 more
doaj   +1 more source

Indeterminate dendritic cell tumor (IDCT) [PDF]

Vestnik Dermatologii i Venerologii, 2023
Indeterminate dendritic cell tumor (IDCT) is rare histiocytic tumor characterized by the proliferation of indeterminate dendritic cells. It is more often diagnosed in middle-aged people, in approximately equal proportions in men and women.
Evgenia V. Okladnikova, Vladimir M. Merk, Yuriy А. Krivopalov, Vladimir А. Khorzhevskii, Tatiana G. Ruksha   +4 more
doaj   +1 more source

Expansion of Phenotypically Altered Dendritic Cell Populations in the Small Airways and Alveolar Parenchyma in Patients with Chronic Obstructive Pulmonary Disease

Journal of Innate Immunity, 2022
Contrasting the antigen-presenting dendritic cells (DCs) in the conducting airways, the alveolar DC populations in human lungs have remained poorly investigated. Consequently, little is known about how alveolar DCs are altered in diseases such as chronic
Michiko Mori, Carl-Magnus Clausson, Caroline Sanden, Jimmie Jönsson, Cecilia K. Andersson, Premkumar Siddhuraj, Medya Shikhagaie, Karolina Åkesson, Anders Bergqvist, Claes-Göran Löfdahl, Jonas S. Erjefält   +10 more
doaj   +1 more source

Targeting of the C-Type Lectin Receptor Langerin Using Bifunctional Mannosylated Antigens

Frontiers in Cell and Developmental Biology, 2020
Langerhans cells (LCs) are antigen-presenting cells that reside in the skin. They uniquely express high levels of the C-type lectin receptor Langerin (CD207), which is an attractive target for antigen delivery in immunotherapeutic vaccination strategies ...
Rui-Jun Eveline Li, Tim P. Hogervorst, Silvia Achilli, Sven C. M. Bruijns, Sander Spiekstra, Corinne Vivès, Michel Thépaut, Dmitri V. Filippov, Gijs A. van der Marel, Sandra J. van Vliet, Franck Fieschi, Jeroen D. C. Codée, Yvette van Kooyk   +12 more
doaj   +1 more source

Usutu virus escapes langerin-induced restriction to productively infect human Langerhans cells, unlike West Nile virus

Emerging Microbes and Infections, 2022
Usutu virus (USUV) and West Nile virus (WNV) are phylogenetically close emerging arboviruses transmitted by mosquitoes, and constitute a global public health threat.
Marie-France Martin, Ghizlane Maarifi, Hervé Abiven, Marine Seffals, Nicolas Mouchet, Cécile Beck, Charles Bodet, Nicolas Lévèque, Nathalie J. Arhel, Fabien P. Blanchet, Yannick Simonin, Sébastien Nisole   +11 more
doaj   +1 more source

Adult-onset of Langerhans cell histiocytosis: a clinical case

Alʹmanah Kliničeskoj Mediciny, 2021
Langerhans cell histiocytosis is mainly diagnosed in children, and its manifestation in adult age is quite uncommon. Skin rashes may be non-specific and mimic a number of dermatoses.
Olga V. Chernysheva, Olga V. Dorokhina, Albina N. Khlebnikova, Elena V. Selezneva   +3 more
doaj   +1 more source

Alteration of the Langerin Oligomerization State Affects Birbeck Granule Formation [PDF]

Biophysical Journal, 2015
Langerin, a trimeric C-type lectin specifically expressed in Langerhans cells, has been reported to be a pathogen receptor through the recognition of glycan motifs by its three carbohydrate recognition domains (CRD). In the context of HIV-1 (human immunodeficiency virus-1) transmission, Langerhans cells of genital mucosa play a protective role by ...
Chabrol, Eric, Thépaut, Michel, Dezutter-Dambuyant, Colette, Vivès, Corinne, Marcoux, Julien, Kahn, Richard, Valladeau-Guilemond, Jenny, Vachette, Patrice, Durand, Dominique, Fieschi, Franck   +9 more
openaire   +3 more sources

Lipo-Based Vaccines as an Approach to Target Dendritic Cells for Induction of T- and iNKT Cell Responses

Frontiers in Immunology, 2020
In this study we developed a liposome-based vaccine containing palmitoylated synthetic long peptides (SLP) and alpha galactosylceramide (αGC) to specifically target dendritic cells (DC) for activation of both innate (invariant natural killer T-cells ...
Dorian A. Stolk, Aram de Haas, Jana Vree, Jana Vree, Sanne Duinkerken, Joyce Lübbers, Rieneke van de Ven, Rieneke van de Ven, Martino Ambrosini, Hakan Kalay, Sven Bruijns, Hans J. van der Vliet, Hans J. van der Vliet, Tanja D. de Gruijl, Yvette van Kooyk   +14 more
doaj   +1 more source

Polymorphisms in Human Langerin Affect Stability and Sugar Binding Activity [PDF]

Journal of Biological Chemistry, 2006
Langerhans cells are specialized skin dendritic cells that take up and degrade antigens for presentation to the immune system. Langerin, a cell surface C-type lectin of Langerhans cells, can be internalized and accumulates in Birbeck granules, subdomains of the endosomal recycling compartment that are specific to Langerhans cells.
Eliot M, Ward, Nicola S, Stambach, Kurt, Drickamer, Maureen E, Taylor   +3 more
openaire   +2 more sources