Results 31 to 40 of about 8,307 (232)

Peritumoural and Intratumoural Distribution of Langerhan Cell in Oral Squamous Cell Carcinoma and its Association with Known Prognostic Factors [PDF]

Journal of Clinical and Diagnostic Research, 2023
Introduction: Oral Squamous Cell Carcinoma (OSCC) accounts for about 2/3rd of the Head and Neck Squamous Cell Carcinomas (HNSCC). It is the sixth most common cancer worldwide and the third most common cancer in developing countries including India.
Sandhra Papparath Usman, Deepti Ramakrishnan, S Divya   +2 more
doaj   +1 more source

Glycosaminoglycans are interactants of Langerin: comparison with gp120 highlights an unexpected calcium-independent binding mode. [PDF]

PLoS ONE, 2012
Langerin is a C-type lectin specifically expressed in Langerhans cells. As recently shown for HIV, Langerin is thought to capture pathogens and mediate their internalisation into Birbeck Granules for elimination.
Eric Chabrol, Alessandra Nurisso, Antoine Daina, Emilie Vassal-Stermann, Michel Thepaut, Eric Girard, Romain R Vivès, Franck Fieschi   +7 more
doaj   +1 more source

A Specific, Glycomimetic Langerin Ligand for Human Langerhans Cell Targeting [PDF]

ACS Central Science, 2019
Langerhans cells are a subset of dendritic cells residing in the epidermis of the human skin. As such, they are key mediators of immune regulation and have emerged as prime targets for novel transcutaneous cancer vaccines. Importantly, the induction of protective T cell immunity by these vaccines requires the efficient and specific delivery of both ...
Eike-Christian Wamhoff, Eike-Christian Wamhoff, Juliane Rademacher, Oliver Seitz, Rob van Dalen, Jessica Schulze, Jessica Schulze, Barbara Del Frari, David Hartmann, Mareike Rentzsch, Nina M. van Sorge, Felix F. Fuchsberger, Felix F. Fuchsberger, Lydia Bellmann, Christoph Rademacher, Christoph Rademacher, Patrizia Stoitzner, Martin Hermann, Gunnar Bachem   +18 more
openaire   +8 more sources

Indeterminate dendritic cell tumor (IDCT) [PDF]

Vestnik Dermatologii i Venerologii, 2023
Indeterminate dendritic cell tumor (IDCT) is rare histiocytic tumor characterized by the proliferation of indeterminate dendritic cells. It is more often diagnosed in middle-aged people, in approximately equal proportions in men and women.
Evgenia V. Okladnikova, Vladimir M. Merk, Yuriy А. Krivopalov, Vladimir А. Khorzhevskii, Tatiana G. Ruksha   +4 more
doaj   +1 more source

Cryo-electron tomography of Birbeck granules reveals the molecular mechanism of langerin lattice formation

eLife, 2022
Langerhans cells are specialized antigen-presenting cells localized within the epidermis and mucosal epithelium. Upon contact with Langerhans cells, pathogens are captured by the C-type lectin langerin and internalized into a structurally unique vesicle ...
Toshiyuki Oda, Haruaki Yanagisawa, Hideyuki Shinmori, Youichi Ogawa, Tatsuyoshi Kawamura   +4 more
doaj   +1 more source

Alteration of the Langerin Oligomerization State Affects Birbeck Granule Formation [PDF]

Biophysical Journal, 2015
Langerin, a trimeric C-type lectin specifically expressed in Langerhans cells, has been reported to be a pathogen receptor through the recognition of glycan motifs by its three carbohydrate recognition domains (CRD). In the context of HIV-1 (human immunodeficiency virus-1) transmission, Langerhans cells of genital mucosa play a protective role by ...
Colette Dezutter-Dambuyant, Eric Chabrol, Jenny Valladeau-Guilemond, Patrice Vachette, Dominique Durand, Julien Marcoux, Julien Marcoux, Corinne Vivès, Corinne Vivès, Richard Kahn, Richard Kahn, Michel Thépaut, Michel Thépaut, Franck Fieschi   +13 more
openaire   +4 more sources

Identification and expression of mouse Langerin (CD207) in dendritic cells [PDF]

International Immunology, 2002
We have cloned the mouse homologue of human Langerin (h-Langerin), a type II transmembrane protein with a single external C-type lectin domain. Mouse Langerin (m-Langerin) displays 65 and 74% homologies in total amino acid and lectin domains with those of h-Langerin. The cognate mouse and rat genes were assigned to chromosome 6D1-D2 and chromosome 4q33
Kazuhiko, Takahara, Yoshiki, Omatsu, Yusuke, Yashima, Yasuhiro, Maeda, Shusaku, Tanaka, Tomonori, Iyoda, Björn E, Clausen, Kazumi, Matsubara, John, Letterio, Ralph M, Steinman, Yoichi, Matsuda, Kayo, Inaba, Bjöern, Clusen   +12 more
openaire   +3 more sources

Rational Design of a DNA‐Scaffolded High‐Affinity Binder for Langerin [PDF]

Angewandte Chemie International Edition, 2020
AbstractBinders of langerin could target vaccines to Langerhans cells for improved therapeutic effect. Since langerin has low affinity for monovalent glycan ligands, highly multivalent presentation has previously been key for targeting. Aiming to reduce the amount of ligand required, we rationally designed molecularly defined high‐affinity binders ...
Bachem, Gunnar, Wamhoff, Eike-Christian, Silberreis, Kim, Kim, Dongyoon, Baukmann, Hannes, Fuchsberger, Felix F., Dernedde, Jens, Rademacher, Christoph, Seitz, Oliver, Fuchsberger, Felix   +9 more
openaire   +4 more sources

Expansion of Phenotypically Altered Dendritic Cell Populations in the Small Airways and Alveolar Parenchyma in Patients with Chronic Obstructive Pulmonary Disease

Journal of Innate Immunity, 2022
Contrasting the antigen-presenting dendritic cells (DCs) in the conducting airways, the alveolar DC populations in human lungs have remained poorly investigated. Consequently, little is known about how alveolar DCs are altered in diseases such as chronic
Michiko Mori, Carl-Magnus Clausson, Caroline Sanden, Jimmie Jönsson, Cecilia K. Andersson, Premkumar Siddhuraj, Medya Shikhagaie, Karolina Åkesson, Anders Bergqvist, Claes-Göran Löfdahl, Jonas S. Erjefält   +10 more
doaj   +1 more source

Targeting of the C-Type Lectin Receptor Langerin Using Bifunctional Mannosylated Antigens

Frontiers in Cell and Developmental Biology, 2020
Langerhans cells (LCs) are antigen-presenting cells that reside in the skin. They uniquely express high levels of the C-type lectin receptor Langerin (CD207), which is an attractive target for antigen delivery in immunotherapeutic vaccination strategies ...
Rui-Jun Eveline Li, Tim P. Hogervorst, Silvia Achilli, Sven C. M. Bruijns, Sander Spiekstra, Corinne Vivès, Michel Thépaut, Dmitri V. Filippov, Gijs A. van der Marel, Sandra J. van Vliet, Franck Fieschi, Jeroen D. C. Codée, Yvette van Kooyk   +12 more
doaj   +1 more source