Results 41 to 50 of about 8,307 (232)
Emerging Microbes and Infections, 2022 Usutu virus (USUV) and West Nile virus (WNV) are phylogenetically close emerging arboviruses transmitted by mosquitoes, and constitute a global public health threat.
Marie-France Martin +11 more
doaj +1 more source
Adult-onset of Langerhans cell histiocytosis: a clinical case
Alʹmanah Kliničeskoj Mediciny, 2021 Langerhans cell histiocytosis is mainly diagnosed in children, and its manifestation in adult age is quite uncommon. Skin rashes may be non-specific and mimic a number of dermatoses.
Olga V. Chernysheva +3 more
doaj +1 more source
Molecular mechanism of the pH-dependent calcium affinity in langerin [PDF]
, 2020 AbstractThe C-type lectin receptor langerin plays a vital role in the mammalian defense against invading pathogens. Its function hinges on the affinity to its co-factor Ca2+which in turn is regulated by the pH. We studied the structural consequences of protonating the allosteric pH-sensor histidine H294 by molecular dynamics simulations (total ...
Joswig, Jan-O. +4 more
openaire +2 more sources
Frontiers in Immunology, 2020 In this study we developed a liposome-based vaccine containing palmitoylated synthetic long peptides (SLP) and alpha galactosylceramide (αGC) to specifically target dendritic cells (DC) for activation of both innate (invariant natural killer T-cells ...
Dorian A. Stolk +14 more
doaj +1 more source
Flt3L-dependence helps define an uncharacterized subset of murine cutaneous dendritic cells [PDF]
, 2014 Skin-derived dendritic cells (DC) are potent antigen presenting cells with critical roles in both adaptive immunity and tolerance to self. Skin DC carry antigens and constitutively migrate to the skin draining lymph nodes (LN).
Anandasabapathy, Niroshana +7 more
core +1 more source
Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state [PDF]
The Journal of Experimental Medicine, 2007 Langerin is a C-type lectin receptor that recognizes glycosylated patterns on pathogens. Langerin is used to identify human and mouse epidermal Langerhans cells (LCs), as well as migratory LCs in the dermis and the skin draining lymph nodes (DLNs). Using a mouse model that allows conditional ablation of langerin+ cells in vivo, together with congenic ...
Florent Ginhoux +12 more
openalex +6 more sources
Depletion of langerin+ cells enhances cutaneous wound healing [PDF]
Immunology, 2020 SummaryLangerin is a C‐type lectin receptor that is expressed on Langerhans cells and langerin‐positive dermal dendritic cells in the skin. Little is known about the function of langerin+ cells in wound healing. In this study, the effects of ablation of langerin+ cells on healing of a full‐thickness excision wound were investigated using the langerin ...
Aarthi Rajesh +6 more
openaire +2 more sources
EMBO Molecular Medicine, 2014 Skin dendritic cells (DCs) control the immunogenicity of cutaneously administered vaccines. Antigens targeted to DCs via the C‐type lectin Langerin/CD207 are cross‐presented to CD8+ T cells in vivo. We investigated the relative roles of Langerhans cells (
Vincent Flacher +6 more
doaj +1 more source
Journal of Advanced Pharmaceutical Technology & Research, 2023 In this study, we investigated whether stimulating the skin with ultrasound (US) could activate Langerhans cells (LCs) – antigen-presenting cells in the epidermis and stimulate antibody production following the subcutaneous and intradermal injection of ...
Satoko Enjo +4 more
doaj +1 more source
HIV Types, Groups, Subtypes and Recombinant Forms: Errors in Replication, Selection Pressure and Quasispecies [PDF]
, 2012 HIV-1 is a chimpanzee virus which was transmitted to humans by several zoonotic events resulting in infection with HIV-1 groups M P, and in parallel transmission events from sooty mangabey monkey viruses leading to infections with HIV-2 groups A H.
Alvarez M +40 more
core +1 more source