Frontiers in Immunology, 2020 Sexually transmitted Hepatitis C virus (HCV) infections and high reinfections are a major concern amongst men who have sex with men (MSM) living with HIV-1 and HIV-negative MSM.
Bernadien M. Nijmeijer +8 more
doaj +1 more source
Identification and Characterization of Endogenous Langerin Ligands in Murine Extracellular Matrix [PDF]
Journal of Investigative Dermatology, 2006 Langerin is a C-type lectin that is expressed by Langerhans cells (LC) and related immune cells, and believed to play an important role in antigen recognition and uptake. To determine if Langerin has endogenous ligands, we generated S protein binding, bacterial recombinant, mouse soluble Langerin, and utilized it as a probe.
David Briner +6 more
openaire +3 more sources
Langerin-Heparin Interaction: Analysis of the Binding to the Non-Lectin Site [PDF]
Natural Product Communications, 2019 Langerin is a C-type lectin involved in the immune response that forms a trimer in its active form. It can interact with carbohydrates using 2 sites with different selectivity, the C-lectin site, a Ca2+-mediated binding, and the cleft between chains. Here we report the complementary analysis of the interaction between a heparin-like hexasaccharide 1 ...
Francisco Corzana +3 more
openaire +3 more sources
Hypomorphic mutation in the RAG2 gene affects dendritic cell distribution and migration. [PDF]
, 2013 In Omenn syndrome, altered dendritic cell distribution and impaired migration represent an additional level of immune dysregulation, contributing to the pathogenesis of autoimmunity. OS is a severe combined immunodeficiency characterized by erythrodermia
Anselmo A +10 more
core +1 more source
mBio, 2019 Staphylococcus aureus is a major cause of skin and soft tissue infections and aggravator of the inflammatory skin disease atopic dermatitis (AD [eczema]). Epicutaneous exposure to S.
Rob van Dalen +12 more
doaj +1 more source
Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells [PDF]
, 2010 Although CD103-expressing dendritic cells (DCs) are widely present in nonlymphoid tissues, the transcription factors controlling their development and their relationship to other DC subsets remain unclear. Mice lacking the transcription factor Batf3 have
Aliberti +75 more
core +3 more sources
The Essential Role of anxA2 in Langerhans Cell Birbeck Granules Formation
Cells, 2020 Langerhans cells (LC) are the resident antigen presenting cells of the mucosal epithelium and play an essential role in initiating immune responses.
Shantae M. Thornton +7 more
doaj +1 more source
A population of Langerin-positive dendritic cells in murine Peyer's patches involved in sampling β-glucan microparticles. [PDF]
PLoS ONE, 2014 Glucan particles (GPs) are 2-4 μm hollow, porous shells composed of 1,3-β-D-glucan that have been effectively used for oral targeted-delivery of a wide range of payloads, including small molecules, siRNA, DNA, and protein antigens.
Magdia De Jesus +4 more
doaj +1 more source
Identification of the Allosteric Binding Site for Thiazolopyrimidine on the C-Type Lectin Langerin
ACS Chemical Biology, 2022 Langerin is a mammalian C-type lectin expressed on Langerhans cells in the skin. As an innate immune cell receptor, Langerin is involved in coordinating innate and adaptive immune responses against various incoming threats. We have previously reported a series of thiazolopyrimidines as murine Langerin ligands. Prompted by the observation that its human
Zhang, Hengxi +11 more
openaire +4 more sources
Increase of DC-LAMP+ mature dendritic cell subsets in dermatopathic lymphadenitis of mycosis fungoides [PDF]
, 2014 Background: Little is known about the immunological milieu of the skin-draining lymph nodes (LNs) in mycosis fungoides (MF). Objectives: We studied dendritic cell (DC) subsets in the dermatopathic lymphadenitis of MF patients.
Aoyama, Yumi +8 more
core +1 more source