Results 71 to 80 of about 8,574 (229)

Molecular Interactions of β-(1→3)-Glucans with Their Receptors

Molecules, 2015
β-(1→3)-Glucans can be found as structural polysaccharides in cereals, in algae or as exo-polysaccharides secreted on the surfaces of mushrooms or fungi.
Laurent Legentil, Franck Paris, Caroline Ballet, Sophie Trouvelot, Xavier Daire, Vaclav Vetvicka, Vincent Ferrières   +6 more
doaj   +1 more source

Efficacy, safety, and relapse outcomes of MAPK inhibitors in pediatric Langerhans cell histiocytosis: A real‐world study

International Journal of Cancer, EarlyView.
What's new? Mitogen‐activated protein kinase (MAPK) inhibitors are promising treatments for pediatric Langerhans cell histiocytosis (LCH), a rare heterogeneous neoplasm that often affects multiple organ systems. Which MAPK inhibitors are most effective against LCH remains uncertain.
Xue Tang, Jing‐jing Sun, Zhi Wan, Xiao‐yu Jing, Xia Guo, Ju Gao   +5 more
wiley   +1 more source

Regulating the adaptive immune response to respiratory virus infection [PDF]

, 2012
This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Braciale, Thomas J., Kim, Taeg S., Sun, Jie   +2 more
core   +1 more source

Single Cell Analysis Reveals Dynamic Changes of Distinct Cell Populations in Human Nickel Allergy

Allergy, EarlyView.
We investigated cell types mediating the early and late inflammatory responses in human Ni2+‐allergy by scRNA‐Seq. Early responsiveness was mainly mediated by TLR4+TAGLN− endothelial cells indirectly activating TLR4−KRT16+ keratinocytes, and CCR7+DCN+ DCs. Late responsiveness was crucially driven by infiltration of KLF2+ central memory T cells and TLR4+
Marc Schmidt, Andrea Knorz, Katharina Meder, Simon Goller, Fabian Imdahl, Yamila Rocca, Matthias Goebeler, Pierre Khoueiry   +7 more
wiley   +1 more source

Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells

Nature Communications, 2021
Epithelial tissue mononuclear phagocytes (MNP) can transmit HIV to CD4 T cells, but less is known about sub-epithelial cells. Here, the authors describe MNPs in human anogenital and colorectal tissues and find that CD14+CD1c+ monocyte-derived dendritic ...
Jake W. Rhodes, Rachel A. Botting, Kirstie M. Bertram, Erica E. Vine, Hafsa Rana, Heeva Baharlou, Peter Vegh, Thomas R. O’Neil, Anneliese S. Ashhurst, James Fletcher, Grant P. Parnell, J. Dinny Graham, Najla Nasr, Jake J. K. Lim, Laith Barnouti, Peter Haertsch, Martijn P. Gosselink, Angelina Di Re, Faizur Reza, Grahame Ctercteko, Gregory J. Jenkins, Andrew J. Brooks, Ellis Patrick, Scott N. Byrne, Eric Hunter, Muzlifah A. Haniffa, Anthony L. Cunningham, Andrew N. Harman   +27 more
doaj   +1 more source

Mafb lineage tracing to distinguish macrophages from other immune lineages reveals dual identity of Langerhans cells [PDF]

, 2016
Current systems for conditional gene deletion within mouse macrophage lineages are limited by ectopic activity or low efficiency. In this study, we generated a Mafb-driven Cre strain to determine whether any dendritic cells (DCs) identified by Zbtb46-GFP
Abram, Anguille, Artner, Artyomov, Bain, Bakri, Bursch, Cain, Carlos G. Briseño, Cassado, Caton, Cheong, Chow, Clausen, Cordes, Croxford, Franklin, Gautier, Ginhoux, Ginhoux, Ginhoux, Ginhoux, Gorman, Greter, Guilliams, Gwendalyn J. Randolph, Helft, Henri, Hertwig, Hoeffel, Hume, Iiizumi, Inaba, Jakubzick, Jakubzick, Jovanovic, Jörn C. Albring, Kaplan, Kelly, Kenneth M. Murphy, Ki-Wook Kim, Kingston, Kissenpfennig, Langlet, Lee, Li, Malay Haldar, Merad, Merad, Meredith, Miller, Mollah, Moriguchi, Plantinga, Poulin, Prachi Bagadia, Randolph, Ranganath, Ryan, Sallusto, Sarrazin, Sato-Nishiwaki, Satpathy, Satpathy, Schaller, Schlitzer, Schwanhäusser, Seré, Silberberg-Sinakin, Soucie, Srinivas, Sultana, Szymczak-Workman, Tamoutounour, Theresa L. Murphy, Vivek Durai, Wang, Xiaodi Wu, Zigmond   +78 more
core   +2 more sources

Langerhans Cell Histiocytosis Presenting With Diabetes Insipidus in a 2 Years Old Child: A Case Report

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT This case report highlights that Langerhans cell histiocytosis should be suspected in the differential diagnosis for children who exhibit failure to thrive, diabetes insipidus, and skin lesions. Early recognition and timely management are crucial for preventing irreversible hypothalamic–pituitary damage and improving outcomes.
Kidus Geabriel Yohannes, Nibretu Bekele Kassa, Zerubabel Girma Tesso, Abubeker Mahammud Digga   +3 more
wiley   +1 more source

Functional Redundancy of Langerhans Cells and Langerin+ Dermal Dendritic Cells in Contact Hypersensitivity [PDF]

Journal of Investigative Dermatology, 2010
The relative roles of Langerhans cells (LC), dermal dendritic cells (DC), and, in particular, the recently discovered Langerin(+) dermal DC subset in the induction and control of contact hypersensitivity (CHS) responses remain controversial. Using an inducible mouse model, in which LC and other Langerin(+) DC can be depleted by injection of diphtheria ...
Noordegraaf, Madelon, Flacher, Vincent, Stoitzner, Patrizia, Clausen, Björn   +3 more
openaire   +3 more sources

Kovalente Aktivierung des C‐Typ Lektins DC‐SIGN

Angewandte Chemie, Volume 138, Issue 3, 16 January 2026.
Wir stellen die ersten kovalenten Aktivatoren eines C‐Typ‐Lektins vor. Mithilfe orthogonaler funktioneller Assays, NMR, MS/MS und computergestützter Modellierung untersuchen wir die Mechanismen eines funktionellen „Electrophile‐first“‐Screenings gegen DC‐SIGN.
Jonathan Lefèbre, Maurice Besch, Noémi Csorba, Kristóf Garami, Zoltán Orgován, Gitta Schlosser, Iris Bermejo, Péter Ábrányi‐Balogh, György M. Keserű, Christoph Rademacher   +9 more
wiley   +1 more source

Morphological Alterations and Increased S100B Expression in Epidermal Langerhans Cells Detected in Skin from Patients with Progressive Vitiligo

Life, 2021
The role of Langerhans cells (LCs) in vitiligo pathogenesis remains unclear, with published studies reporting contradictory results regarding the quantity of LCs and no data on the features of LCs in vitiligo.
Fei Yang, Lingli Yang, Lanting Teng, Huimin Zhang, Ichiro Katayama   +4 more
doaj   +1 more source