Results 81 to 90 of about 8,574 (229)

Covalent Activation of the C‐type Lectin DC‐SIGN

Angewandte Chemie International Edition, Volume 65, Issue 3, 16 January 2026.
We introduce the first covalent activators of a C‐type lectin. Using orthogonal functional assays, NMR, MS/MS, and computational modeling, we delineate mechanisms from a functional electrophile‐first screen on dendritic cell‐specific intercellular adhesion molecule‐3‐grabbing non‐integrin (DC‐SIGN) that yields two modes: N‐hydroxysuccinimide (NHS ...
Jonathan Lefèbre, Maurice Besch, Noémi Csorba, Kristóf Garami, Zoltán Orgován, Gitta Schlosser, Iris Bermejo, Péter Ábrányi‐Balogh, György M. Keserű, Christoph Rademacher   +9 more
wiley   +1 more source

Calcium‐Independent Activation of an Allosteric Network in Langerin by Heparin Oligosaccharides [PDF]

ChemBioChem, 2017
AbstractThe C‐type lectin receptor Langerin is a glycan‐binding protein that serves as an uptake receptor on Langerhans cells and is essential for the formation of Birbeck granules. Whereas most Langerin ligands are recognized by a canonical Ca2+‐dependent binding site, heparins have been proposed to make additional contacts to a secondary, Ca2 ...
Jonas Hanske, Robert Wawrzinek, Andreas Geissner, Eike‐Christian Wamhoff, Katrin Sellrie, Henrik Schmidt, Peter H. Seeberger, Christoph Rademacher   +7 more
openaire   +3 more sources

Filaggrin-null mutations are associated with increased maturation markers on Langerhans cells [PDF]

, 2016
Background Mutations in the gene encoding filaggrin (FLG), an epidermal structural protein, are the strongest risk factor identified for the development of atopic dermatitis (AD).
Andrew J. Muinonen-Martin, Angelova-Fischer, Banchereau, Bashir, Berth-Jones, Brown, Chu, Claire S. Leitch, Correale, Cunjing Yu, Dahl, Di Gennaro, Eenass Natafji, Elias, Gibbs, Gibbs, Gibbs, Gilmour, Gilmour, Harriott-Smith, Jürgen Schwarze, Kammeyer, Kammeyer, Kaneko, Kezic, Laihia, Leung, Linda E. Campbell, Loffler, McAleer, McGrath, Meunier, Nayani Madarasingha, Norval, Pasanen, Pasanen, Paul M. Fitch, Peltonen, Pinnagoda, Prechtel, Richard B. Weller, Roland Chu, Romani, Romani, Ross, Sadhu, Sarah E.M. Howie, Seneschal, Sergeant, Sharizan Abdul-Ghaffar, Shibaki, Smith, W.H. Irwin McLean, Williams, Yoshida, Zoë C. Venables   +55 more
core   +4 more sources

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

BRAF V600E and Pten deletion in mice produces a histiocytic disorder with features of Langerhans cell histiocytosis.

PLoS ONE, 2019
Langerhans cell histiocytosis (LCH) is characterized by the accumulation of Langerin (CD207)-expressing histiocytes. Mutational activation of mitogen-activated protein kinase pathway genes, in particular BRAF, drives most cases. To test whether activated
David S Nelson, Ryan L Marano, Yechaan Joo, Sara Y Tian, Bhumi Patel, Daniel H Kaplan, Mark J Shlomchik, Kristen Stevenson, Roderick T Bronson, Barrett J Rollins   +9 more
doaj   +1 more source

Evaluation of Antigen Expression and Early Immune Response Following Cutaneous Suction‐Mediated DNA Delivery

Advanced Therapeutics, Volume 9, Issue 1, January 2026.
In vivo suction‐based cutaneous DNA vaccination promotes robust immunogenic responses. The spatiotemporal patterns of antigen expression following suction‐based SARS‐CoV‐2 DNA vaccine delivery are evaluated in rat skin via immunofluorescence staining.
Nandita C. Jhumur, Yukyung Um, Sarah H. Park, Emran O. Lallow, Christine C. Roberts, Jerry W. Shan, Jonathan P. Singer, Jeffrey D. Zahn, Young K. Park, Lisa K. Denzin, David I. Shreiber, Joel N. Maslow, Hao Lin   +12 more
wiley   +1 more source

Langerin-Heparin Interaction: Analysis of the Binding to the Non-Lectin Site [PDF]

Natural Product Communications, 2019
Langerin is a C-type lectin involved in the immune response that forms a trimer in its active form. It can interact with carbohydrates using 2 sites with different selectivity, the C-lectin site, a Ca2+-mediated binding, and the cleft between chains. Here we report the complementary analysis of the interaction between a heparin-like hexasaccharide 1 ...
García-Jiménez, María José, Corzana, Francisco, Paz, José L. de, Nieto, Pedro M.   +3 more
openaire   +2 more sources

The PDK1-Rsk signaling pathway controls Langerhans cell proliferation and patterning [PDF]

, 2015
Langerhans cells (LC), the dendritic cells of the epidermis, are distributed in a distinctive regularly spaced array. In the mouse, the LC array is established in the first few days of life from proliferating local precursors, but the regulating ...
Edgar, Alexander J., Gomez-Nicola, Diego, Hanauer, André, Matthews, Stephen P., Prescott, Alan R., Watts, Colin, Zaru, Rossana   +6 more
core   +3 more sources

ALK‐Positive Histiocytosis With Unilateral Breast Involvement: A Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT APH is a rare disorder characterized by the proliferation of ALK‐expressing histiocytes with variable anatomical involvement; however, mammary involvement is exceptionally rare. A 32‐year‐old woman presented with a painless right breast mass. Ultrasound identified a 9 × 8 mm hypoechoic nodule, categorized as BI‐RADS 4A.
Xuechun Liu, Dong Ren, Yanfang Liang
wiley   +1 more source

Langerhans cells and more: langerin‐expressing dendritic cell subsets in the skin [PDF]

Immunological Reviews, 2010
Summary:  Langerhans cells (LCs) are antigen‐presenting dendritic cells (DCs) that reside in epithelia. The best studied example is the LC of the epidermis. By electron microscopy, their identifying feature is the unique rod‐ or tennis racket‐shaped Birbeck granule.
Romani, N, Clausen, Björn, Stoitzner, P
openaire   +2 more sources