Results 81 to 90 of about 8,360 (233)

Molecular Interactions of β-(1→3)-Glucans with Their Receptors

Molecules, 2015
β-(1→3)-Glucans can be found as structural polysaccharides in cereals, in algae or as exo-polysaccharides secreted on the surfaces of mushrooms or fungi.
Laurent Legentil, Franck Paris, Caroline Ballet, Sophie Trouvelot, Xavier Daire, Vaclav Vetvicka, Vincent Ferrières   +6 more
doaj   +1 more source

Morphological Alterations and Increased S100B Expression in Epidermal Langerhans Cells Detected in Skin from Patients with Progressive Vitiligo

Life, 2021
The role of Langerhans cells (LCs) in vitiligo pathogenesis remains unclear, with published studies reporting contradictory results regarding the quantity of LCs and no data on the features of LCs in vitiligo.
Fei Yang, Lingli Yang, Lanting Teng, Huimin Zhang, Ichiro Katayama   +4 more
doaj   +1 more source

Filaggrin-null mutations are associated with increased maturation markers on Langerhans cells [PDF]

, 2016
Background Mutations in the gene encoding filaggrin (FLG), an epidermal structural protein, are the strongest risk factor identified for the development of atopic dermatitis (AD).
Andrew J. Muinonen-Martin, Angelova-Fischer, Banchereau, Bashir, Berth-Jones, Brown, Chu, Claire S. Leitch, Correale, Cunjing Yu, Dahl, Di Gennaro, Eenass Natafji, Elias, Gibbs, Gibbs, Gibbs, Gilmour, Gilmour, Harriott-Smith, Jürgen Schwarze, Kammeyer, Kammeyer, Kaneko, Kezic, Laihia, Leung, Linda E. Campbell, Loffler, McAleer, McGrath, Meunier, Nayani Madarasingha, Norval, Pasanen, Pasanen, Paul M. Fitch, Peltonen, Pinnagoda, Prechtel, Richard B. Weller, Roland Chu, Romani, Romani, Ross, Sadhu, Sarah E.M. Howie, Seneschal, Sergeant, Sharizan Abdul-Ghaffar, Shibaki, Smith, W.H. Irwin McLean, Williams, Yoshida, Zoë C. Venables   +55 more
core   +4 more sources

Langerhans cells and more: langerin‐expressing dendritic cell subsets in the skin [PDF]

Immunological Reviews, 2010
Summary:  Langerhans cells (LCs) are antigen‐presenting dendritic cells (DCs) that reside in epithelia. The best studied example is the LC of the epidermis. By electron microscopy, their identifying feature is the unique rod‐ or tennis racket‐shaped Birbeck granule.
Björn E. Clausen, Nikolaus Romani, Patrizia Stoitzner   +2 more
openaire   +3 more sources

The Clinicopathologic Spectrum of Rosai–Dorfman–Destombes Disease in Adults: An Analysis of 16 Cases

European Journal of Haematology, EarlyView.
ABSTRACT Rosai–Dorfman–Destombes disease (RDD) is a rare histiocytic proliferation with protean clinical manifestations, resulting from the accumulation of activated histiocytes within nodal and extra‐nodal tissues. The diagnosis can be missed, particularly when biopsies are obtained from extra‐nodal sites, where histological features may be less ...
Mark Trinder, Collin Pryma, Emily Leung, Graham W. Slack, Pedro Farinha, Sean Young, Neval Ozkaya, Mollie Carruthers, Luke Y. C. Chen   +8 more
wiley   +1 more source

Mafb lineage tracing to distinguish macrophages from other immune lineages reveals dual identity of Langerhans cells [PDF]

, 2016
Current systems for conditional gene deletion within mouse macrophage lineages are limited by ectopic activity or low efficiency. In this study, we generated a Mafb-driven Cre strain to determine whether any dendritic cells (DCs) identified by Zbtb46-GFP
Abram, Anguille, Artner, Artyomov, Bain, Bakri, Bursch, Cain, Carlos G. Briseño, Cassado, Caton, Cheong, Chow, Clausen, Cordes, Croxford, Franklin, Gautier, Ginhoux, Ginhoux, Ginhoux, Ginhoux, Gorman, Greter, Guilliams, Gwendalyn J. Randolph, Helft, Henri, Hertwig, Hoeffel, Hume, Iiizumi, Inaba, Jakubzick, Jakubzick, Jovanovic, Jörn C. Albring, Kaplan, Kelly, Kenneth M. Murphy, Ki-Wook Kim, Kingston, Kissenpfennig, Langlet, Lee, Li, Malay Haldar, Merad, Merad, Meredith, Miller, Mollah, Moriguchi, Plantinga, Poulin, Prachi Bagadia, Randolph, Ranganath, Ryan, Sallusto, Sarrazin, Sato-Nishiwaki, Satpathy, Satpathy, Schaller, Schlitzer, Schwanhäusser, Seré, Silberberg-Sinakin, Soucie, Srinivas, Sultana, Szymczak-Workman, Tamoutounour, Theresa L. Murphy, Vivek Durai, Wang, Xiaodi Wu, Zigmond   +78 more
core   +2 more sources

Beyond Hepatitis: A Rare Case of Multisystem Langerhans Cell Histiocytosis in a Child

Clinical Case Reports, Volume 13, Issue 11, November 2025.
ABSTRACT Langerhans cell histiocytosis (LCH) is a rare neoplastic disorder involving abnormal proliferation of dendritic cells, with clinical presentations ranging from isolated lesions to life‐threatening multisystem involvement. This case report describes a 26‐month‐old girl who presented with progressive jaundice, fever, hepatomegaly, pruritic scalp
Dilip Neupane, Rishi Ram Banjade, Dhiraj Joshi, Pusp Raj Awasthi, Santosh Mishra   +4 more
wiley   +1 more source

glycomimetic langerin ligands for langerhans cell targeting

, 2017
Immune evasion represents an important hallmark of cancer progression. In this context, the induction of tumor-specific cytotoxic T cell immunity to overcome immunological tolerance has become a focal point of cancer immunotherapy. Langerhans cells (LCs) constitute a dendritic cell (DC) subset residing in the epidermis of the human skin. They have been
openaire   +3 more sources

BRAF V600E and Pten deletion in mice produces a histiocytic disorder with features of Langerhans cell histiocytosis.

PLoS ONE, 2019
Langerhans cell histiocytosis (LCH) is characterized by the accumulation of Langerin (CD207)-expressing histiocytes. Mutational activation of mitogen-activated protein kinase pathway genes, in particular BRAF, drives most cases. To test whether activated
David S Nelson, Ryan L Marano, Yechaan Joo, Sara Y Tian, Bhumi Patel, Daniel H Kaplan, Mark J Shlomchik, Kristen Stevenson, Roderick T Bronson, Barrett J Rollins   +9 more
doaj   +1 more source

The PDK1-Rsk signaling pathway controls Langerhans cell proliferation and patterning [PDF]

, 2015
Langerhans cells (LC), the dendritic cells of the epidermis, are distributed in a distinctive regularly spaced array. In the mouse, the LC array is established in the first few days of life from proliferating local precursors, but the regulating ...
Edgar, Alexander J., Gomez-Nicola, Diego, Hanauer, André, Matthews, Stephen P., Prescott, Alan R., Watts, Colin, Zaru, Rossana   +6 more
core   +3 more sources