Results 21 to 30 of about 17,586 (206)
Acta Crystallographica Section E: Crystallographic Communications, 2019 The structure of the title compound, C32H51NO6, was determined from 62-year-old crystals at room temperature and refined with 100 K data in a monoclinic (C2) space group. This compound with a triterpenoid structure, now confirmed by this study, played an
Leopoldo Suescun, Horacio Heinzen
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Pubertal presentation in seven patients with congenital adrenal hyperplasia due to P450 Oxidoreductase deficiency [PDF]
, 2010 Context: P450 oxidoreductase (POR) is a crucial electron donor to all microsomal P450 cytochrome (CYP) enzymes including 17α-hydroxylase (CYP17A1), 21-hydroxylase (CYP21A2) and P450 aromatase.
Adachi +59 more
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Ergosterol reduction impairs mitochondrial DNA maintenance in S. cerevisiae [PDF]
, 2019 Sterols are essential lipids, involved in many biological processes. In Saccharomyces cerevisiae, the enzymes of the ergosterol biosynthetic pathway (Erg proteins) are localized in different cellular compartments.
Balliano, Gianni +6 more
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Improvement of experimental testing and network training conditions with genome-wide microarrays for more accurate predictions of drug gene targets [PDF]
, 2014 BACKGROUND: Genome-wide microarrays have been useful for predicting chemical-genetic interactions at the gene level. However, interpreting genome-wide microarray results can be overwhelming due to the vast output of gene expression data combined with off-
Christadore, Lisa M. +3 more
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Ergosterol and Lanosterol from Aspergillus nidulans [PDF]
Microbiology, 1982 Ergosterol was identified as the major free sterol of Aspergillus nidulans by thin-layer chromatography, alumina column chromatography, gas-liquid chromatography, high-performance liquid chromatography, UV spectroscopy, proton magnetic resonance spectroscopy and mass spectral analysis.
B E, Shapiro, M A, Gealt
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Preparation and properties of a cell-free system from rat skin that catalyzes sterol biosynthesis
Journal of Lipid Research, 1966 Homogenates of epidermis from rat skin were centrifuged at 10,000 · g for 20 min. The supernatant fraction (“whole homogenate”) catalyzed the demethylation of lanosterol (C30) to yield C27-sterols. The rate of reaction was measured by the rate of release
J.L. Gaylor +3 more
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Evaluation of Antimicrobial Activity of Some Hybrids of Pyrimidine-Azole Derivatives along with Molecular docking study [PDF]
Trends in Pharmaceutical Sciences, 2023 Despite extensive research on antimicrobial drugs, efforts to find suitable alternatives to older drugs have not been very successful yet, due to microbial resistance.
Leila Emami +4 more
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Journal of Lipid Research, 2010 The Forkhead transcription factors FoxO1, FoxO3a, and FoxO4 play a prominent role in regulating cell survival and cell cycle. Whereas FOXO1 was shown to mediate insulin sensitivity and adipocyte differentiation, the role of the transcription factor FoxO4
Jun Zhu +5 more
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Plant oxidosqualene metabolism: cycloartenol synthase-dependent sterol biosynthesis in Nicotiana benthamiana. [PDF]
PLoS ONE, 2014 The plant sterol pathway exhibits a major biosynthetic difference as compared with that of metazoans. The committed sterol precursor is the pentacyclic cycloartenol (9β,19-cyclolanost-24-en-3β-ol) and not lanosterol (lanosta-8,24-dien-3β-ol), as it was ...
Elisabet Gas-Pascual +3 more
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Indonesian Journal of Pharmaceutical Education, 2023 Candida albicans (C. albicans) is a fungus that causes candidiasis. C. albicans has the enzyme Lanosterol 14- α demethylase. Lanosterol 14-α-demethylase has bioactivity in converting lanosterol to ergosterol, a special sterol found in fungal membranes,
Nurul Istiqomah +2 more
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