Results 31 to 40 of about 17,586 (206)

Endogenous sterol intermediates of the mevalonate pathway regulate HMGCR degradation and SREBP-2 processing[S]

Journal of Lipid Research, 2019
Sterol-regulated HMG-CoA reductase (HMGCR) degradation and SREBP-2 cleavage are two major feedback regulatory mechanisms governing cholesterol biosynthesis.
Liang Chen, Mei-Yan Ma, Ming Sun, Lu-Yi Jiang, Xue-Tong Zhao, Xian-Xiu Fang, Sin Man Lam, Guang-Hou Shui, Jie Luo, Xiong-Jie Shi, Bao-Liang Song   +10 more
doaj   +1 more source

Ophthalmic In Situ Gelling System Containing Lanosterol Nanoparticles Delays Collapse of Lens Structure in Shumiya Cataract Rats

Pharmaceutics, 2020
We attempted to prepare ophthalmic in situ gel formulations containing lanosterol (Lan) nanoparticles (LA-NPs/ISG) and investigated the characteristics, delivery pathway into the lens, and anti-cataract effects of LA-NPs/ISG using SCR-N (rats with slight
Noriaki Nagai, Kazuki Umachi, Hiroko Otake, Mikako Oka, Noriko Hiramatsu, Hiroshi Sasaki, Naoki Yamamoto   +6 more
doaj   +1 more source

An RNAi-Based Control of Fusarium graminearum Infections Through Spraying of Long dsRNAs Involves a Plant Passage and Is Controlled by the Fungal Silencing Machinery [PDF]

, 2016
Meeting the increasing food and energy demands of a growing population will require the development of ground-breaking strategies that promote sustainable plant production.
Abdellatef, Eltayb, Biedenkopf, Dagmar, Cardoza, Vinitha, Furch, Alexandra, Goesmann, Alexander, Jelonek, Lukas, Johannsmeier, Jan, Koch, Aline, Kogel, Karl-Heinz, Linicus, Lukas, McMillan, John, Mentzel, Tobias, Rossbach, Oliver, Weber, Lennart   +13 more
core   +3 more sources

Effects of oxygenated lanosterol analogs on cholesterol biosynthesis from lanosterol.

Chemical and Pharmaceutical Bulletin, 1983
The effects of oxygenated lanosterol derivatives (1-14) on cholesterol biosynthesis from [24-3H]-lanosterol were tested in 10000×g supernatant (S10) fraction of rat liver homogenate (RLH). Among the derivatives studied, 7-oxo-24, 25-dihydrolanosterol (11) was most active in depressing cholesterol biosynthesis from lanosterol.
Y, Sonoda, Y, Sato
openaire   +3 more sources

Lanosterol Modulates TLR4-Mediated Innate Immune Responses in Macrophages

Cell Reports, 2017
Macrophages perform critical functions in both innate immunity and cholesterol metabolism. Here, we report that activation of Toll-like receptor 4 (TLR4) in macrophages causes lanosterol, the first sterol intermediate in the cholesterol biosynthetic ...
Elisa Araldi, Marta Fernández-Fuertes, Alberto Canfrán-Duque, Wenwen Tang, Gary W. Cline, Julio Madrigal-Matute, Jordan S. Pober, Miguel A. Lasunción, Dianqing Wu, Carlos Fernández-Hernando, Yajaira Suárez   +10 more
doaj   +1 more source

Sterol profiling of Leishmania parasites using a new HPLC-tandem mass spectrometry-based method and antifungal azoles as chemical probes reveals a key intermediate sterol that supports a branched ergosterol biosynthetic pathway

International Journal for Parasitology: Drugs and Drug Resistance, 2022
Human leishmaniasis is an infectious disease caused by Leishmania protozoan parasites. Current chemotherapeutic options against the deadly disease have significant limitations.
Mei Feng, Yiru Jin, Sihyung Yang, Arline M. Joachim, Yu Ning, Luis M. Mori-Quiroz, Jacob Fromm, Chamani Perera, Kai Zhang, Karl A. Werbovetz, Michael Zhuo Wang   +10 more
doaj   +1 more source

Using genetics to investigate the association between lanosterol and cataract

Frontiers in Genetics
Background: Cataract is one of the most prevalent causes of blindness worldwide. Whilst surgery is the primary treatment for cataracts, it is not always an available option, particularly in developing countries.
Munisa Hashimi, Hasnat A. Amin, Loukas Zagkos, Alexander C. Day, Alexander C. Day, Fotios Drenos   +5 more
doaj   +1 more source

Structure Prediction and Functional Characterization of ERG Proteins Involved in Ergosterol Biosynthetic Pathway of Candida albicans [PDF]

, 2011
The ERG proteins and enzymes of the ergosterol biosynthetic pathway has been the subject of intensive investigation as a target for several classes of antifungal agents used to treat C. albicans infection. Over the past few decades, a number of drugs and
Ashok Sharma, Suaib Luqman, Sudeep Roy   +2 more
core   +2 more sources

The Effect of Small Molecules on Sterol Homeostasis: Measuring 7-Dehydrocholesterol in Dhcr7-Deficient Neuro2a Cells and Human Fibroblasts [PDF]

, 2018
K
Balogh, István, Kim, Hye-Young H., Koczok, Katalin, Korade, Zeljka, Liu, Wei, Mirnics, Károly, Porter, Ned A., Tallman, Keri A., Xu, Libin   +8 more
core   +1 more source

Lanosterol 14 alpha-demethylase (P45014DM): effects of P45014DM inhibitors on sterol biosynthesis downstream of lanosterol.

Journal of Lipid Research, 1991
Lanosterol 14 alpha-demethylase (P45014DM) is the cytochrome P450 enzyme complex responsible for an early step in cholesterol biosynthesis, namely the 14 alpha-demethylation of lanosterol.
SF Tuck, H Patel, E Safi, CH Robinson
doaj   +1 more source