Results 1 to 10 of about 16,901 (224)

Molecular diagnostics for lassa fever at Irrua specialist teaching hospital, Nigeria: lessons learnt from two years of laboratory operation. [PDF]

PLoS Neglected Tropical Diseases, 2012
BACKGROUND: Lassa fever is a viral hemorrhagic fever endemic in West Africa. However, none of the hospitals in the endemic areas of Nigeria has the capacity to perform Lassa virus diagnostics.
Danny A Asogun, Donatus I Adomeh, Jacqueline Ehimuan, Ikponmwonsa Odia, Meike Hass, Martin Gabriel, Stephan Olschläger, Beate Becker-Ziaja, Onikepe Folarin, Eric Phelan, Philomena E Ehiane, Veritas E Ifeh, Eghosasere A Uyigue, Yemisi T Oladapo, Ekene B Muoebonam, Osagie Osunde, Andrew Dongo, Peter O Okokhere, Sylvanus A Okogbenin, Mojeed Momoh, Sylvester O Alikah, Odigie C Akhuemokhan, Peter Imomeh, Maxy A C Odike, Stephen Gire, Kristian Andersen, Pardis C Sabeti, Christian T Happi, George O Akpede, Stephan Günther   +29 more
doaj   +4 more sources

Analysis of synonymous codon usage bias of Lassa virus [PDF]

Virus Research
Lassa virus genome consists of two single-stranded, negative-sense RNA segments that lie in the genus Arenavirus. The disease associated with the Lassa virus is distributed all over the world, with approximately 3,000,000–5,000,000 infections diagnosed ...
Siddiq Ur Rahman, Yikui Hu, Hassan Ur Rehman, May M. Alrashed, Kotb A. Attia, Ubaid Ullah, Huiying Liang   +6 more
doaj   +2 more sources

Rodent control strategies and Lassa virus: some unexpected effects in Guinea, West Africa [PDF]

Emerging Microbes and Infections
The Natal multimammate mouse (Mastomys natalensis) is the host of Lassa mammarenavirus, causing Lassa haemorrhagic fever in West Africa. As there is currently no operational vaccine and therapeutic drugs are limited, we explored rodent control as an ...
Joachim Mariën, Mickaël Sage, Umaru Bangura, Alicia Lamé, Michel Koropogui, Toni Rieger, Barré Soropogui, Moussa Douno, N’Faly Magassouba, Elisabeth Fichet-Calvet   +9 more
doaj   +2 more sources

Expansion of CD8+ T cell population in Lassa virus survivors with low T cell precursor frequency reveals durable immune response in most survivors.

PLoS Neglected Tropical Diseases, 2022
IntroductionLassa virus is a priority pathogen for vaccine research and development, however the duration of cellular immunity and protection in Lassa fever (LF) survivors remains unclear.MethodsWe investigated Lassa virus specific CD8+ T cell responses ...
Stephanie M LaVergne, Saori Sakabe, Mambu Momoh, Lansana Kanneh, Nell Bond, Robert F Garry, Donald S Grant, Juan Carlos de la Torre, Michael B A Oldstone, John S Schieffelin, Brian M Sullivan   +10 more
doaj   +1 more source

A Lassa virus mRNA vaccine confers protection but does not require neutralizing antibody in a guinea pig model of infection

Nature Communications, 2023
Lassa virus is a member of the Arenaviridae family, which causes human infections ranging from asymptomatic to severe hemorrhagic disease with a high case fatality rate.
Adam J. Ronk, Nicole M. Lloyd, Min Zhang, Caroline Atyeo, Hailee R. Perrett, Chad E. Mire, Kathryn M. Hastie, Rogier W. Sanders, Philip J. M. Brouwer, Erica Olmann Saphire, Andrew B. Ward, Thomas G. Ksiazek, Juan Carlos Alvarez Moreno, Harshwardhan M. Thaker, Galit Alter, Sunny Himansu, Andrea Carfi, Alexander Bukreyev   +17 more
doaj   +1 more source

Virus persistence after recovery from acute Lassa fever in Nigeria: a 2-year interim analysis of a prospective longitudinal cohort study

The Lancet Microbe, 2022
Summary: Background: There is anecdotal evidence for Lassa virus persistence in body fluids. We aimed to investigate various body fluids after recovery from acute Lassa fever, describe the dynamics of Lassa virus RNA load in seminal fluid, and assess ...
Anke Thielebein, PhD, Yemisi Ighodalo, MSc, Abubakar Taju, MD, Thomas Olokor, MSc, Racheal Omiunu, BSc, Rita Esumeh, MSc, Paulson Ebhodaghe, BSc, Anieno Ekanem, BSc, Ganiyu Igenegbale, MSc, Rosemary Giwa, BSc, Annick Renevey, PhD, Julia Hinzmann, Jonas Müller, Elisa Pallasch, Meike Pahlmann, PhD, Jeremie Guedj, PhD, Joy Nwatuzor, BSc, Oluwasola Femi Babatunde, BSc, Donatus I Adomeh, PhD, Danny Asogun, MD, Nosa Akpede, MD, Sylvanus Okogbenin, ProfMD, Stephan Günther, ProfMD, Lisa Oestereich, PhD, Sophie Duraffour, PhD, Ephraim Ogbaini-Emovon, MD   +25 more
doaj   +1 more source

Survival of Lassa Virus in Blood and Tissue Culture Media and in a Small Particle Aerosol

Pathogens, 2020
Knowledge of the survival and stability of a pathogen is important for understanding its risk, reducing its transmission, and establishing control measures.
Sophie J Smither, Lin S Eastaugh, James S Findlay, Lyn M O’Brien, Mark S Lever   +4 more
doaj   +1 more source

The risk of transmission of a viral haemorrhagic fever infection in a United Kingdom laboratory [PDF]

, 2017
No abstract ...
Shorten, Robert J., Wilson-Davies, Eleri
core   +7 more sources

Predicting the evolution of the Lassa virus endemic area and population at risk over the next decades

Nature Communications, 2022
It is currently unknown how climate and land use changes could affect the endemic area of Lassa virus, a zoonotic pathogen responsible for Lassa fever.
Raphaëlle Klitting, Liana E. Kafetzopoulou, Wim Thiery, Gytis Dudas, Sophie Gryseels, Anjali Kotamarthi, Bram Vrancken, Karthik Gangavarapu, Mambu Momoh, John Demby Sandi, Augustine Goba, Foday Alhasan, Donald S. Grant, Sylvanus Okogbenin, Ephraim Ogbaini-Emovo, Robert F. Garry, Allison R. Smither, Mark Zeller, Matthias G. Pauthner, Michelle McGraw, Laura D. Hughes, Sophie Duraffour, Stephan Günther, Marc A. Suchard, Philippe Lemey, Kristian G. Andersen, Simon Dellicour   +26 more
doaj   +1 more source

Lethal Infection of Lassa Virus Isolated from a Human Clinical Sample in Outbred Guinea Pigs without Adaptation

mSphere, 2019
Lassa virus (LASV), a member of the family Arenaviridae, is the causative agent of Lassa fever. Lassa virus is endemic in West African countries, such as Nigeria, Guinea, Liberia, and Sierra Leone, and causes outbreaks annually.
Junki Maruyama, John T. Manning, Elizabeth J. Mateer, Rachel Sattler, Natalya Bukreyeva, Cheng Huang, Slobodan Paessler   +6 more
doaj   +1 more source