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Pathogenesis of Lassa Fever

open access: yesViruses, 2012
Lassa virus, an Old World arenavirus (family Arenaviridae), is the etiological agent of Lassa fever, a severe human disease that is reported in more than 100,000 patients annually in the endemic regions of West Africa with mortality rates for ...
David H. Walker, Nadezhda E. Yun
doaj   +1 more source

An overview of Lassa fever

open access: yesWikiJournal of Medicine, 2019
Lassa fever is a viral hemorrhagic fever caused by Lassa virus (Lassa mammarenavirus), a negative-sense single-stranded RNA virus of the Arenaviridae family. In most cases Lassa virus infection is asymptomatic (presenting no symptom). When symptomatic it
Abdulmutalab Musa
doaj   +1 more source

Comparative structural and functional analysis of Bunyavirus and Arenavirus cap-snatching Endonucleases [PDF]

open access: yes, 2016
Segmented negative strand RNA viruses of the arena-, bunya- and orthomyxovirus families uniquely carry out viral mRNA transcription by the cap-snatching mechanism.
A Dias   +47 more
core   +3 more sources

Development of a new vaccine for the prevention of Lassa fever.

open access: yesPLoS Medicine, 2005
BackgroundRecent importation of Lassa fever into Germany, the Netherlands, the United Kingdom, and the United States by travelers on commercial airlines from Africa underscores the public health challenge of emerging viruses.
Thomas W Geisbert   +15 more
doaj   +2 more sources

Use of Favipiravir to Treat Lassa Virus Infection in Macaques

open access: yesEmerging Infectious Diseases, 2018
Lassa virus, the cause of Lassa fever in humans, is endemic to West Africa. Treatment of Lassa fever is primarily supportive, although ribavirin has shown limited efficacy if administered early during infection.
Kyle Rosenke   +12 more
doaj   +1 more source

A GIS-BASED APPROACH TO RISK MAPPING OF LASSA FEVER OUTBREAK IN AKURE SOUTH LOCAL GOVERNMENT AREA, NIGERIA [PDF]

open access: yesThe International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2022
Lassa fever is an acute viral illness, which is endemic in some counties in West Africa, including Guinea, Liberia, Sierra Leone and parts of Nigeria.
O. J. Ifejube   +3 more
doaj   +1 more source

Data from: A systematic review and meta-analysis of seroprevalence surveys of ebolavirus infection [PDF]

open access: yes, 2017
The dataset contains findings and information from 51 seroprevelance studies performed from on samples collected from 1961 to 2016. These investigated 84 exposure-defined subgroups of subjects reported to have had no symptoms of EVD during the outbreak ...
Bower, Hilary, Glynn, Judith
core   +2 more sources

Development of a minigenome cassette for Lettuce necrotic yellows virus: A first step in rescuing a plant cytorhabdovirus [PDF]

open access: yes, 2020
Rhabdoviruses are enveloped negative-sense RNA viruses that have numerous biotechnological applications. However, recovering plant rhabdoviruses from cDNA remains difficult due to technical difficulties such as the need for concurrent in planta ...
Drake, P   +3 more
core   +1 more source

Crystal structure of Schmallenberg orthobunyavirus nucleoprotein-RNA complex reveals a novel RNA sequestration mechanism [PDF]

open access: yes, 2013
Schmallenberg virus (SBV) is a newly emerged orthobunyavirus (family Bunyaviridae) that has caused severe disease in the offspring of farm animals across Europe.
Bottcher, B.   +4 more
core   +1 more source

Development and evaluation of antibody-capture immunoassays for detection of Lassa virus nucleoprotein-specific immunoglobulin M and G. [PDF]

open access: yesPLoS Neglected Tropical Diseases, 2018
The classical method for detection of Lassa virus-specific antibodies is the immunofluorescence assay (IFA) using virus-infected cells as antigen.
Martin Gabriel   +23 more
doaj   +1 more source

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