Results 151 to 160 of about 307,788 (176)

Knocking Out Two Polyphenol Oxidase Genes Significantly Improves Recombinant Protein Purification in Nicotiana benthamiana

Plant Biotechnology Journal, EarlyView.
ABSTRACT Efficient purification remains a key technical challenge affecting the recovery efficiency of recombinant proteins in plant‐based systems. Complex metabolites, particularly polyphenols, often cause recombinant protein aggregation during purification.
Hai‐Ping Diao, Hui‐Xin Meng, Xue‐Jiao Xu, Zeng‐Lin Zhang, Jian‐Feng Zhang, Yong‐Feng Guo, Inhwan Hwang, Shi‐Jian Song   +7 more
wiley   +1 more source

Gene Editing of Nicotiana benthamiana Architecture for Space‐Efficient Production of Recombinant Proteins in Closed Environments

Plant Biotechnology Journal, EarlyView.
ABSTRACT Indoor vertical farming (VF) offers practical advantages for the cultivation of plant protein bio‐factories including plant uniformity, product consistency, water/nutrient recycling and production cycles on a year‐round basis. Much progress has been achieved toward the development of innovative systems for artificial lighting, automated ...
Béatrice Giroux, Kristina LeBreux, Louis Feyzeau, Marie‐Claire Goulet, Charles Goulet, Dominique Michaud   +5 more
wiley   +1 more source

Plasma 3‐O‐Methyldopa Concentration Monitoring for Treatment Optimization in Foslevodopa/Foscarbidopa Infusion: Implications for Corrected Levodopa Availability: A Case Report

Movement Disorders Clinical Practice, EarlyView.
Shohei Okusa, Kotaro Okada, Yoshihiro Nihei, Risano Sakai, Takeshi Akiyoshi, Tomonori Nukariya, Jin Nakahara, Hisakazu Ohtani, Morinobu Seki   +8 more
wiley   +1 more source

Climate Shapes Elevational Gradients in Concentration, Composition, and Functional Diversity of Willow Metabolomes

Plant, Cell &Environment, EarlyView.
ABSTRACT Plants produce broad spectra of metabolites comprising primary metabolites involved in core physiological processes and specialized metabolites mediating responses to biotic and abiotic stress. Understanding how these various components of the metabolome respond to different environmental pressures can help us to understand drivers of ...
Sofian A. Renoult, Priscila Mezzomo, Jing V. Leong, Pavel Sebek, Shristee Panthee, Jaroslav Kukla, Petr Nguyen, Martin Moos, Dale L. Forrister, Natascha D. Wagner, Elvira Hörandl, Petr Koutecký, Brian E. Sedio, Jan Frouz, Nicole M. van Dam, Martin Volf   +15 more
wiley   +1 more source

Development of chalcones structure‐related to avobenzone: Photoprotection, photostability, and safety evaluation

Photochemistry and Photobiology, EarlyView.
Scaffold hopping strategy used to develop chalcones structure‐related to the avobenzone tautomer. Positive aspects of 2‐hydroxychalcones are highlighted. Abstract Chalcones are α,β‐unsaturated ketones with extended π‐conjugation, making them promising scaffolds for the development of organic UV filters.
Gabriela Zanella Marcon, Taíne de Bastos Brum, Nayara Fernanda Tokashike de Araujo, Gabriela Lascala Ramos, Bruna Cogo Borin, Ruth Barin, Aline Ferreira Ourique, André Passaglia Schuch, Andréa Inês Horn Adams, Lorena Rigo Gaspar Cordeiro, Letícia Cruz, Fernando Fumagalli   +11 more
wiley   +1 more source

Detection and Excretion Profile of Retatrutide in Human Plasma and Urine by LC‐HRMS: Implications for Antidoping Analysis

Rapid Communications in Mass Spectrometry, Volume 40, Issue 23, 15 December 2026.
ABSTRACT Rationale Retatrutide (LY3437943) is a novel long‐acting triple incretin receptor agonist that targets the glucagon‐like peptide‐1 receptor (GLP‐1R), glucose‐dependent insulinotropic polypeptide receptor (GIPR), and glucagon receptor (GCGR). Its pronounced effects on body composition and metabolic health, combined with increasing off‐label use
Gabriel Reis Alves Carneiro, Isabelle Karine da Costa Nunes, Gustavo Ramalho dos Santos Cardoso, Paola Façanha dos Santos, Monica Costa Padilha, Fábio César Sousa Nogueira, Henrique Marcelo Gualberto Pereira   +6 more
wiley   +1 more source

Metabolomic Mapping of Greek Olive Leaves by Untargeted NMR‐Based Profiling and LC–HRMS Dereplication

Analytical Science Advances, Volume 7, Issue 2, December 2026.
ABSTRACT Olive tree leaves are phytochemically rich yet insufficiently valorised in terms of systematic cultivar‐based characterisation and exploitation, and are an abundant olive industry side‐product. This study represents the first large‐scale metabolome mapping based on 340 leaf extracts from five major Greek cultivars (Amfissis, Koroneiki, Manaki,
Mariacaterina Lianza, Stavros Beteinakis, Vasileios Siderakis, Panagiotis Stathopoulos, Emmanuel Hatzakis, Maria Halabalaki   +5 more
wiley   +1 more source

Profiling Hydrolysis Rates of αS1‐Casein to αS1‐I‐Casein During Cheese Ripening by Intact‐Protein Liquid Chromatography–High Resolution Mass Spectrometry

Rapid Communications in Mass Spectrometry, Volume 40, Issue 21, 15 November 2026.
ABSTRACT Rationale The proteolytic behavior of chymosins during cheese ripening impacts cheese texture, flavor, and quality. Especially, the specific hydrolysis of αS1‐casein to αS1‐I‐casein is relevant for early cheese texture development, and this activity varies between chymosin variants.
Sebastiaan Dolman, Marjolein van der Eijk, Loes Bevers, Kees Muijlwijk, Mee Loke Lim, Margriet Hendriks, Nicolas Abello, Rob van der Hoeven   +7 more
wiley   +1 more source

A Dual GC–MS and LC–MS/MS Analytical Strategy for Evaluating Free Chlorine Toxicity in Aqueous Samples

Rapid Communications in Mass Spectrometry, Volume 40, Issue 20, 30 October 2026.
ABSTRACT Rationale Chlorine gas is a highly toxic industrial chemical that poses a significant risk in accidental releases and deliberate terrorist attacks. Reliable analytical methods for the determination of chlorine in aqueous samples are therefore required for forensic and environmental investigations.
Avital Shifrovitch, Adi Tzadok, Moran Madmon, Avi Weissberg   +3 more
wiley   +1 more source

High‐Resolution LC–MS/MS Characterization of Budmunchiamine‐Type Alkaloids in Albizia niopoides

Rapid Communications in Mass Spectrometry, Volume 40, Issue 19, 15 October 2026.
ABSTRACT Rationale Budmunchiamines are macrocyclic spermine alkaloids that constitute a distinctive class of polyamine natural products predominantly found in species of the genus Albizia. Comprehensive characterization of these compounds remains challenging because of their structural diversity and the limited availability of reference standards. This
Maria L. A. Majevski, Lienne D'Auria Lima, Adriana C. C. Reis, Leonan I. C. R. Santos, Brenno F. S. Vargas, Markus Kohlhoff, Geraldo Célio Brandão   +6 more
wiley   +1 more source