War on Viruses: LC3 Recruits GTPases [PDF]
Cell Host & Microbe, 2017 Interferon effector functions and autophagy are evolutionarily conserved arms of cell-autonomous immunity that restrict replication of intracellular pathogens. In this issue of Cell Host and Microbe, Biering et al., (2017) demonstrate how host cells co-opt sequential action of autophagy proteins and IFN-inducible GTPases to inhibit replication of ...
Teneema, Kuriakose +1 more
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Evaluating Autophagy in Preimplantation Embryos
Autophagy Reports, 2022 Autophagy is an essential cellular degradation pathway in the mammalian preimplantation embryo. In this review, the process of autophagy is outlined and its function pertaining to preimplantation embryos is discussed.
Zuleika C. L. Leung +4 more
doaj +1 more source
Autophagy generates citrullinated peptides in human synoviocytes: a possible trigger for anti-citrullinated peptide antibodies [PDF]
, 2016 OBJECTIVES: Autophagy may represent a functional processing event that creates a substrate for autoreactivity. In particular, autophagy may play a role in the pathogenesis of RA, since autophagy is a key cellular event involved in the generation of ...
Alessandra Nerviani +14 more
core +1 more source
LC3 and STRAP regulate actin filament assembly by JMY during autophagosome formation. [PDF]
, 2019 During autophagy, actin filament networks move and remodel cellular membranes to form autophagosomes that enclose and metabolize cytoplasmic contents. Two actin regulators, WHAMM and JMY, participate in autophagosome formation, but the signals linking ...
Axe +40 more
core +2 more sources
Regulation of autophagy-related gene expressions by Trans-chalcone in the lungs of adult male rats [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریزBackground. Autophagy is responsible for maintaining cellular homeostasis by degrading and recycling macromolecules and unwanted intracellular components, such as damaged organelles.
Fatemeh Salehi Mazdeh +4 more
doaj +1 more source
Energies, 2023 Mineral carbonation incurs high operating costs, as large amounts of chemicals and energy must be used in the process. Its implementation on an industrial scale requires reducing expenditures on chemicals and energy consumption.
Natália R. Galina +3 more
doaj +1 more source
Niclosamide Triggers Non-Canonical LC3 Lipidation [PDF]
Cells, 2019 Autophagy is a highly- evolutionarily-conserved catabolic pathway activated by various cellular stresses. Recently, non-canonical autophagy (NCA), which does not require all of the ATG proteins to form autophagosome or autophagosome-like structures, has been found in various conditions.
Liu, Yajun +12 more
openaire +3 more sources
Alpha-mangostin decreases high glucose-induced damage on human umbilical vein endothelial cells by increasing autophagic protein expression [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Diabetes is a chronic disorder that occurs as a result of impaired glucose metabolism. In hyperglycaemic states, the balance between oxidative stress and antioxidant enzymes is disrupted leading to oxidative damage and cell death.
Farhad Eisvand +3 more
doaj +1 more source
CD4 T lymphocyte autophagy is upregulated in the salivary glands of primary Sjögren’s syndrome patients and correlates with focus score and disease activity [PDF]
, 2017 Background: Primary Sjögren’s syndrome (pSS) is a common chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands and peripheral lymphocyte perturbation.
A Bhattacharya +58 more
core +3 more sources
p62/SQSTM1 droplets initiate autophagosome biogenesis and oxidative stress control
Molecular & Cellular Oncology, 2021 Selective autophagy contributes to the degradation of condensates, such as sequestosome 1-bodies, also called p62/SQSTM1-bodies. We showed that endogenous p62 forms gel-like structures, which serve as platforms for autophagosome formation and nuclear ...
Eeva-Liisa Eskelinen +2 more
doaj +1 more source