Results 61 to 70 of about 100,610 (290)

The aberrant expression of the mesenchymal variant of FGFR2 in the epithelial context inhibits autophagy [PDF]

, 2019
Signaling of the epithelial splice variant of fibroblast growth factor receptor 2 (FGFR2b) triggers both differentiation and autophagy, while the aberrant expression of the mesenchymal FGFR2c isoform in epithelial cells induces impaired differentiation ...
Belleudi, Francesca, Nanni, Monica, Persechino, Flavia, Ranieri, Danilo, Torrisi, Maria Rosaria   +4 more
core   +1 more source

LC3 conjugation system in mammalian autophagy

The International Journal of Biochemistry & Cell Biology, 2004
Autophagy is the bulk degradation of proteins and organelles, a process essential for cellular maintenance, cell viability, differentiation and development in mammals. Autophagy has significant associations with neurodegenerative diseases, cardiomyopathies, cancer, programmed cell death, and bacterial and viral infections.
Tanida, Isei, Ueno, Takashi, Kominami, Eiki   +2 more
openaire   +2 more sources

Recruitment of LC3 to damaged Golgi apparatus [PDF]

Cell Death & Differentiation, 2018
LC3 is a protein that can associate with autophagosomes, autolysosomes, and phagosomes. Here, we show that LC3 can also redistribute toward the damaged Golgi apparatus where it clusters with SQSTM1/p62 and lysosomes. This organelle-specific relocation, which did not involve the generation of double-membraned autophagosomes, could be observed after ...
Gomes-Da-Silva, Lígia, Jimenez, Ana Joaquina, Sauvat, Allan, Xie, Wei, Souquere, Sylvie, Divoux, Séverine, Storch, Marko, Sveinbjørnsson, Baldur, Rekdal, Øystein, Arnaut, Luis, Kepp, Oliver, Kroemer, Guido, Perez, Franck   +12 more
openaire   +2 more sources

Beyond autophagy: LC3-associated phagocytosis and endocytosis

Science Advances, 2022
Noncanonical functions of the autophagy machinery in pathways including LC3-associated phagocytosis and LC3-associated endocytosis have garnered increasing interest in both normal physiology and pathobiology. New discoveries over the past decade of noncanonical uses of the autophagy machinery in these distinct molecular mechanisms have led to robust ...
Carolina Peña-Martinez, Alexis D. Rickman, Bradlee L. Heckmann   +2 more
openaire   +2 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Antiretroviral Drugs Impact Autophagy: Opportunities for Drug Repurposing

Frontiers in Bioscience-Landmark
Autophagy is an evolutionarily conserved process in which intracellular macromolecules are degraded in a lysosomal-dependent manner. It is central to cellular energy homeostasis and to quality control of intracellular components.
Laura Cheney, John M. Barbaro, Grace McDermott, Joan W. Berman   +3 more
doaj   +1 more source

Autophagy in Microglia and Alzheimer's disease [PDF]

, 2019
Alzheimer’s disease (AD) is the most common neurodegenerative disease, characterized by amyloid-beta plaques, neurofibrillary tangles and neuroinflammation. Autophagy has been associated with several neurodegenerative diseases.
Houtman, Judith
core   +1 more source

LC3-associated phagocytosis in microbial pathogenesis

International Journal of Medical Microbiology, 2018
Phagocytosis is essential for uptake and elimination of pathogenic microorganisms. Autophagy is a highly conserved mechanism for incorporation of cellular constituents to replenish nutrients by degradation. Recently, parts of the autophagy machinery - above all microtubule-associated protein 1 light chain 3 (LC3) - were found to be specifically ...
Stefan, Schille, Peter, Crauwels, Rebecca, Bohn, Katrin, Bagola, Paul, Walther, Ger, van Zandbergen   +5 more
openaire   +2 more sources

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Localization of Autophagosome in Porcine Follicular Cumulus-oocyte Complex

Journal of Animal Reproduction and Biotechnology, 2017
Autophagy is an intracellular degradation and recycling system. Oocyte maturation is dynamic process, in which various proteins should be synthesized and degraded.
Seunghoon Lee, Dong-Hoon Kim, Gi-Sun Im, Sun-A Ock, Imran Ullah, Tai-Young Hur   +5 more
doaj   +1 more source