Results 51 to 60 of about 1,425,998 (283)

Bayesian learning of joint distributions of objects [PDF]

open access: yes, 2013
There is increasing interest in broad application areas in defining flexible joint models for data having a variety of measurement scales, while also allowing data of complex types, such as functions, images and documents. We consider a general framework
Banerjee, Anjishnu   +2 more
core  

Content-driven design and architecture of E-learning applications [PDF]

open access: yes, 2008
E-learning applications combine content with learning technology systems to support the creation of content and its delivery to the learner. In the future, we can expect the distinction between learning content and its supporting infrastructure to become
Pahl, Claus
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Learning objects and learning designs: an integrated system for reusable, adaptive and shareable learning content [PDF]

open access: yes, 2005
This paper proposes a system, the Smart Learning Design Framework, designed to support the development of pedagogically sound learning material within an integrated, platform-independent data structure.
Agostinho   +5 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Hierarchical Deep Learning Architecture For 10K Objects Classification

open access: yes, 2015
Evolution of visual object recognition architectures based on Convolutional Neural Networks & Convolutional Deep Belief Networks paradigms has revolutionized artificial Vision Science.
Bedi, Amish Kumar   +4 more
core   +1 more source

Weakly Supervised Learning of Objects, Attributes and Their Associations [PDF]

open access: yes, 2014
The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-319-10605-2_31]”
Hospedales, TM   +3 more
core   +3 more sources

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Los Objetos de Aprendizaje y su aplicación en la Experiencia Educativa "Algorítmica"

open access: yesCPU-e, 2012
En este trabajo se describe cómo el concepto de objeto de aprendizaje suscita nuevas formas de operar la información, propiciadas por la tecnología predominante de Internet.
María Luisa Velasco Ramírez
doaj   +1 more source

Home - About - Disclaimer - Privacy