Results 41 to 50 of about 647,862 (252)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

THE DEVELOPMENT OF STORY BOOK “IKAN SAKTI SUNGAI JANIAH" AS A LEARNING RESOURCE OF LITERATURE AT ELEMENTARY SCHOOL

Jurnal PAJAR (Pendidikan dan Pengajaran), 2020
This research aims at developing folklore story book of " Ikan Sakti Sungai Janiah" and finding out its feasibility. The story book was designed by using coreldraw7. Model 4D was used as the research method by using four stages; those are define, design,
Suci Amalia, Gustimal Witri
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Commentary by Ed Walker on Littlejohn, A. (2003) Reusing Online Resources, Chapter 11: Digital Libraries and Repositories, by Charles Duncan and Cuna Ekmekioglu

Journal of Interactive Media in Education, 2004
: Duncan and Ekmekcioglu begin their chapter with the ritual observation that learning resources (i.e., library assets) are becoming ever easier to reproduce and distribute... After making only brief comments about better infrastructure for databases and
Ed Walker
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Medical educators in action: Development of learning resources

Journal of Clinical Sciences
Learning resources refer to the tools, materials, and approaches that are employed to support teaching and facilitate learning in terms of acquisition of knowledge and skills.
Saurabh RamBihariLal Shrivastava, Prateek Saurabh Shrivastava, Abhishek Joshi   +2 more
doaj   +1 more source

Commentary by Tom Vreeland on Littlejohn, A. (2003) Reusing Online Resources, Chapter 13: Use and Reuse of Digital Images in Teaching and Learning, by Grainne Conole, Jill Evans and Ellen Sims

Journal of Interactive Media in Education, 2004
: Conole, Evans and Simms, the authors of Chapter 13, Use and Reuse of Digital Images in Teaching and Learning, have provided a coherent and well structured description of the issues involved in use of digital imagery in education.
Tom S. Vreeland
doaj   +1 more source

Helping students to learn how to critically evaluate a source: how effective are the tools we use?

Journal of Learning Development in Higher Education, 2023
What does evaluating a source involve? What aspects of the source are being evaluated? On what basis do we determine a source’s strengths and weaknesses? And how do we explain this to students who are learning the basics of critical analysis?
Edward Powell, Sonia Hood
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source