Results 51 to 60 of about 17,486 (290)
G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis
Advanced Science, EarlyView.Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang +9 more
wiley +1 more source
Advanced Science, EarlyView.The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi +8 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng +15 more
wiley +1 more source
Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair
Advanced Science, EarlyView.We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing +10 more
wiley +1 more source
The application of the theory of norms to the translations of international treaties : a case study of the Jordan-Israel peace treaty [PDF]
, 2003 EThOS - Electronic Theses Online ServiceGBUnited ...
Masa'deh, Orieb Khalaf
core
A Piezo‐Mimetic Ionic Hydrogel Harnessing Joint Motion for Cartilage Repair
Advanced Science, EarlyView.A piezo‐mimetic ionic hydrogel converts mechanical deformation into bioactive ionic currents via stress‐induced asymmetric ion migration. Coupled with sustained Mg2+ release, this mechano‐electrochemical platform bridges mechanical loading and cellular signaling, enabling load‐adaptive stimulation and enhanced cartilage regeneration. ABSTRACT Articular
Chenyuan Gao +14 more
wiley +1 more source
Comparative Legilinguistics, 2020 Authors of translations of legal codes do not usually inform about their approach to solving translational problems. One of the reasons is the firm belief in the need for a faithful and thus literal translation of the output text. This unlawful approach
Łukasz Iluk
doaj +4 more sources
THE WEB AS CORPUS AND ONLINE CORPORA FOR LEGAL TRANSLATIONS
Comparative Legilinguistics, 2019 Legal language is hallmarked by a pedantic and user-unfriendly jargon whose constructs are all but intuitive, not to mention the legal system specificity which makes it unique in every country.
Patrizia GIAMPIERI
doaj +2 more sources
Advanced Science, EarlyView.PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin +11 more
wiley +1 more source
The Role of SHALL and SHOULD in Two International Treaties
Critical Approaches to Discourse Analysis across Disciplines, 2009 The aim of this study is to analyse the language of two international treaties, the United Nations Charter (1945) and the European Convention on Human Rights (1950). As a work in progress it investigates the role of SHALL and SHOULD in the institutional
Germana D’Acquisto +1 more
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