Results 1 to 10 of about 16,570 (161)

Mechanisms of Immune Evasion, Dissemination, and Persistence in Leishmania amazonensis Infection. [PDF]

Parasite Immunol
ABSTRACT Leishmania amazonensis is one of the etiological agents of cutaneous leishmaniasis in its localised form. Moreover, this parasite can cause more severe disease conditions, such as diffuse and disseminated cutaneous leishmaniasis. The development of more severe clinical manifestations is associated with the parasite's ability to establish a ...
Portugal AB, DaMatta RA, da Cunha Júnior EF, Wanderley JLM.   +3 more
europepmc   +2 more sources

Leishmania amazonensis promastigotes in 3D Collagen I culture: an in vitro physiological environment for the study of extracellular matrix and host cell interactions [PDF]

PeerJ, 2014
Leishmania amazonensis is the causative agent of American cutaneous leishmaniasis, an important neglected tropical disease. Once Leishmania amazonensis is inoculated into the human host, promastigotes are exposed to the extracellular matrix (ECM) of the ...
Debora B. Petropolis, Juliany C.F. Rodrigues, Nathan B. Viana, Bruno Pontes, Camila F.A. Pereira, Fernando C. Silva-Filho   +5 more
doaj   +5 more sources

VAPA mediates lipid exchange between Leishmania amazonensis and host macrophages. [PDF]

PLoS Pathogens
Leishmania is a vacuolar pathogen that replicates within parasitophorous vacuoles inside host phagocytes. To promote its replication, Leishmania relies on a panoply of strategies to acquire macromolecules such as lipids from host macrophages.
Ilona Gdovinova, Albert Descoteaux
doaj   +2 more sources

Visceral leishmaniasis patients display altered composition and maturity of neutrophils as well as impaired neutrophil effector functions [PDF]

, 2016
Immunologically, active visceral leishmaniasis (VL) is characterised by profound immunosuppression, severe systemic inflammatory responses and an impaired capacity to control parasite replication.
Adem, E, Cruz Cervera, E, Diro, E, Getahun, M, Hailu, A, Kropf, P, Lemma, M, Melkamu, R, Mengesha, B, Mesfin, G, Modolell, M, Muller, I, Munder, M, Skhedy, Z, Tajebe, F, Takele, Y, Van der Auwera, G, Yardley, V, Yeshanew, A, Yizengaw, E   +19 more
core   +13 more sources

Imidazolium salts as an alternative for anti-Leishmania drugs: Oxidative and immunomodulatory activities

Frontiers in Immunology, 2023
In this study we explored the previously established leishmanicidal activity of a complementary set of 24 imidazolium salts (IS), 1-hexadecylimidazole (C16Im) and 1-hexadecylpyridinium chloride (C16PyrCl) against Leishmania (Leishmania) amazonensis and ...
Fernanda Giesel Baldissera, Fernanda Giesel Baldissera, Tiago Fazolo, Tiago Fazolo, Matheus Brasil da Silva, Paulo Cesar de Santana Filho, Vinícius Demétrio da Silva, David Max Rivillo Perez, Joice Sandra Klitzke, Eduardo Giovanni de Oliveira Soares, Luiz Carlos Rodrigues Júnior, Luiz Carlos Rodrigues Júnior, Alessandra Peres, Alessandra Peres, Eliane Dallegrave, Kely Campos Navegantes-Lima, Marta Chagas Monteiro, Henri Stephan Schrekker, Pedro Roosevelt Torres Romão, Pedro Roosevelt Torres Romão, Pedro Roosevelt Torres Romão   +20 more
doaj   +1 more source

Innate Resistance to Leishmania amazonensis Infection in Rat Is Dependent on NOS2

Frontiers in Microbiology, 2021
Leishmania infection causes diverse clinical manifestations in humans. The disease outcome is complicated by the combination of many host and parasite factors.
Yun-Fu Chen, Si-Fei Yu, Chang-You Wu, Na Wu, Jia Shen, Juan Shen, Jiang-Mei Gao, Yan-Zi Wen, Geoff Hide, De-Hua Lai, Zhao-Rong Lun, Zhao-Rong Lun   +11 more
doaj   +1 more source

A Betulinic Acid Derivative, BA5, Induces G0/G1 Cell Arrest, Apoptosis Like-Death, and Morphological Alterations in Leishmania sp

Frontiers in Pharmacology, 2022
Leishmaniasis are endemic diseases caused by different species of intracellular parasites of the genus Leishmania. Due to the high toxicity and drug resistance of current antileishmanial drugs, it is necessary to identify new and more effective drugs ...
Tatiana Barbosa dos Santos Magalhães, Tatiana Barbosa dos Santos Magalhães, Dahara Keyse Carvalho Silva, Dahara Keyse Carvalho Silva, Jessica da Silva Teixeira, Jessica da Silva Teixeira, Juliana Dizaira Teles De Lima, Juliana Dizaira Teles De Lima, José Maria Barbosa-Filho, Diogo Rodrigo Magalhães Moreira, Elisalva Teixeira Guimarães, Elisalva Teixeira Guimarães, Milena Botelho Pereira Soares, Milena Botelho Pereira Soares   +13 more
doaj   +1 more source

Experimental infection and transmission of Leishmania by Lutzomyia cruzi (Diptera: Psychodidae): Aspects of the ecology of parasite-vector interactions. [PDF]

PLoS Neglected Tropical Diseases, 2017
Several parameters should be addressed before incriminating a vector for Leishmania transmission. Those may include its ability to become infected by the same Leishmania species found in humans, the degree of attractiveness for reservoirs and humans and ...
Everton Falcão de Oliveira, Elisa Teruya Oshiro, Wagner de Souza Fernandes, Paula Guerra Murat, Márcio José de Medeiros, Alda Izabel Souza, Alessandra Gutierrez de Oliveira, Eunice Aparecida Bianchi Galati   +7 more
doaj   +1 more source

DH82 Canine and RAW264.7 Murine Macrophage Cell Lines Display Distinct Activation Profiles Upon Interaction With Leishmania infantum and Leishmania amazonensis

Frontiers in Cellular and Infection Microbiology, 2020
Leishmaniasis is an anthropozoonotic disease, and dogs are considered the main urban reservoir of the parasite. Macrophages, the target cells of Leishmania sp., play an important role during infection.
Natalia Rocha Nadaes, Leandro Silva da Costa, Raissa Couto Santana, Isabel Ferreira LaRocque-de-Freitas, Áislan de Carvalho Vivarini, Deivid Costa Soares, Amanda Brito Wardini, Ulisses Gazos Lopes, Elvira M. Saraiva, Celio Geraldo Freire-de-Lima, Debora Decote-Ricardo, Lucia Helena Pinto-da-Silva   +11 more
doaj   +1 more source

In vitro and in vivo Anti-leishmanial Potential of [Ag (PTA) 4 ]BF 4 and [Ag(HBPz 3 )(PPh 3 )] Silver Complexes

Revista da Sociedade Brasileira de Medicina Tropical, 2022
Background: American tegumentary leishmaniasis is a parasitic disease known for being difficult to treat; therefore, the search for more effective therapeutic methods is necessary.
Pauline de Faria Soldera, Ana Flavia da Silva Chagas, Anny Maisa Vargas Brasil, Claudia Dantas Comandolli-Wyrepkowski, Marina Porchia, Antonia Maria Ramos Franco Pereira   +5 more
doaj   +1 more source