Results 11 to 20 of about 59,340 (183)

Sphingolipid degradation in Leishmania (Leishmania) amazonensis.

PLoS Neglected Tropical Diseases, 2012
BackgroundHuman leishmaniasis is caused by more than 20 Leishmania species and has a wide range of symptoms. Our recent studies have demonstrated the essential role of sphingolipid degradation in the virulence of Leishmania (Leishmania) major, a species ...
Agiesh Balakrishna Pillai, Wei Xu, Ou Zhang, Kai Zhang   +3 more
doaj   +4 more sources

Experimental treatment with sodium stibogluconate of hamsters infected with Leishmania (Leishmania) chagasi and Leishmania (Leishmania) amazonensis [PDF]

Revista da Sociedade Brasileira de Medicina Tropical, 1999
The present paper reports the experimental treatment of hamsters infected with Leishmania chagasi and Leishmania amazonensis with sodium stibogluconate (20mg/kg/day x 20 days). Only with L.
Elizabeth M. de Figueiredo, Jaime Costa e Silva, Reginaldo P. Brazil   +2 more
doaj   +4 more sources

The role of surface glycoconjugates in Leishmania midgut attachment examined by competitive binding assays and experimental development in sand flies [PDF]

, 2013
SUMMARY Binding of promastigotes to the sand fly midgut epithelium is regarded as an essential part of the Leishmania life cycle in the vector. Among Leishmania surface molecules putatively involved in attachment to the sand fly midgut, two GPI-anchored ...
Jecna, Lucie, Bates, Paul A., Seblova, Veronika, Volf, Petr, Dostalova, Anna, Wilson, Ray, Chang, Kwang-Poo   +6 more
core   +5 more sources

Transcriptional responses of Leishmania (Leishmania) amazonensis in the presence of trivalent sodium stibogluconate [PDF]

Parasites & Vectors, 2019
Background In the last decade, resistance to antimonials has become a serious problem due to the emergence of drug-resistant strains. Therefore, understanding the mechanisms used by Leishmania parasites to survive under drug pressure is essential ...
Luz H. Patino, Carlos Muskus, Juan David Ramírez   +2 more
doaj   +3 more sources

Inhibition of Leishmania (Leishmania) amazonensis growth and infectivity by aureobasidin A [PDF]

Journal of Antimicrobial Chemotherapy, 2007
To study the effect of aureobasidin A, an inhibitor of inositol phosphorylceramide (IPC) synthase, on Leishmania growth and infectivity.Effects of aureobasidin A were determined for: (i) promastigote growth in axenic culture; (ii) promastigote infectivity in macrophage monolayers; (iii) development of footpad lesions in BALB/c mice; (iv ...
Ameria K, Tanaka, Valderez B, Valero, Helio K, Takahashi, Anita H, Straus   +3 more
openaire   +2 more sources

Axenic cultivation and characterization of Leishmania mexicana amastigote-like forms [PDF]

, 1992
A new method is described which has made possible the long-term axenic cultivation of Leishmania mexicana amastigote-like forms in Schneider's Drosophila medium supplemented with 20% (v/v) foetal calf serum.
Coombs, G H, Robertson, C D, Tetley, L, Bates, P A   +3 more
core   +4 more sources

T helper1/T helper2 cells and resistance/susceptibility to Leishmania infection : is this paradigm still relevant? [PDF]

, 2012
Work in large part on Leishmania major in the 1980s identified two distinct apparently counter-regulatory CD4 T cell populations, T helper (h)1 and Th2, that controlled resistance/susceptibility to infection respectively.
Brombacher, F., Alexander, J.
core   +4 more sources

Effects of Brazilian propolis on Leishmania amazonensis [PDF]

Memórias do Instituto Oswaldo Cruz, 2007
Leishmaniasis, an endemic parasitosis that leads to chronic cutaneous, mucocutaneous or visceral lesions, is part of those diseases, which still requires improved control tools. Propolis has shown activities against different bacteria, fungi, and parasites.
Ayres, Diana Copi, Marcucci, Maria Cristina, Giorgio, Selma   +2 more
openaire   +4 more sources

BALB/c mice deficient in CD4(+) T cell IL-4R alpha expression control Leishmania mexicana load although female but not male mice develop a healer phenotype [PDF]

, 2011
Immunologically intact BALB/c mice infected with Leishmania mexicana develop non-healing progressively growing lesions associated with a biased Th2 response while similarly infected IL-4R alpha-deficient mice fail to develop lesions and develop a robust ...
Mokgethi, Thabang, Alexander, James, Bryson, Karen, Millington, Owain, Brombacher, Frank, McGachy, Adrienne   +5 more
core   +4 more sources

Establishment of a transdermal infection model with Leishmania amazonensis. [PDF]

Parasit Vectors
Abstract Background Leishmaniasis, a parasitic disease caused by Leishmania protozoa, has various clinical forms and is endemic in Brazil.
Manhães NC, Praxedes H, Da-Rocha AA, de Almeida DB, Dos Santos IB, da Silva-Junior EB, Covre L, Freire-de-Lima CG, Oliveira Gomes DC, da-Cruz AM, da Fonseca-Martins AM, de Matos Guedes HL.   +11 more
europepmc   +4 more sources