Results 51 to 60 of about 13,685 (176)

Phototoxic effect of aluminium-chlorine and aluminium-hydroxide phthalocyanines on Leishmania (l.) amazonensis

Photodiagnosis and Photodynamic Therapy, 2018
This study investigated the activity of photosensitive phthalocyanines on promastigotes and amastigotes of Leishmania (L.) amazonensis. Aluminum phthalocyanine chloride (AlPcCl), Aluminum phthalocyanine hydroxide (AlPcOH) and zinc phthalocyanine (PcZn) were tested in the presence (matte red LED, potency of 2.5-2.3 μW for 30 min) and absence of light ...
V, Nesi-Reis, T R, Navasconi, D S S L, Lera-Nosone, E L, Oliveira, P M, Barbosa, W, Caetano, T G V, Silveira, S M A, Aristides, N, Hioka, M V C, Lonardoni   +9 more
openaire   +2 more sources

2-Substituted quinoline alkaloids as potential antileishmanial drugs [PDF]

, 1993
Ten 2-substituted quinoline alkaloids isolated from a plant used for treatment of New World cutaneous leishmaniasis have antileishmanial in vitro activities against the extracellular forms of Leishmania spp.
Barrios, A.A., Bruneton, J., Cavé, A., Fournet, Alain, Hocquemiller, R., Munoz, V.   +5 more
core   +1 more source

Cytotoxic and Antileishmanial Potential of Pilocarpus microphyllus Essential Oil: In Vitro and In Silico Study

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
Jaborandi (Pilocarpus microphyllus) essential oil is obtained by removal and characterization using GC‐MS, revealing γ‐cadinene and trans‐caryophyllene as major constituents. The oil exhibits biological activity, with antifungal action against Candida spp.
Juniel Cruz Silva, Maria Gabriela Araújo Mendes, Paulo Sérgio de Araujo Sousa, Alyne Rodrigues de Araújo Nobre, Michel Muálem de Moraes Alves, Fernando Aécio de Amorim Carvalho, Tatiane Caroline Daboit, José de Sousa Lima Neto, Ygor Victor Ferreira Pinheiro, Ytallo da Costa Sousa, Edymilaís da Silva Sousa, José Delano Barreto Marinho Filho, Ana Jérsia Araújo, Francisco Artur Silva Filho, Sidney Gonçalo de Lima, Leiz Maria Costa Véras   +15 more
wiley   +1 more source

Leishmania (L.) amazonensis peptidase activities inside the living cells and in their lysates

Molecular and Biochemical Parasitology, 2012
In this study we investigated the peptidase activity in Leishmania (L.) amazonensis live amastigote by confocal microscopy using peptidyl-MCA as substrates, the hydrolysis of which releases the MCA fluorophore inside the cells. Cell pre-treatment with peptidase inhibitors indicated the presence of cysteine and serine peptidases.
Caroselli, Elide E., Assis, Diego M., Barbiéri, Clara L., Júdice, Wagner A.S., Juliano, Maria A., Gazarini, Marcos L., Juliano, Luiz   +6 more
openaire   +2 more sources

Citrus reticulata Blanco: A Review on Chemical Composition and Biological Activities

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
This review compiles chemical information and biological activities from 49 studies on Citrus reticulata. The fruit peels stand out for their high content of methoxylated monoterpenes and flavonoids with antioxidant, anti‐inflammatory, and antimicrobial activities.
José Walber Gonçalves Castro, Geane Gabriele de Oliveira Souza, José Galberto Martins da Costa, Fabíola Fernandes Galvão Rodrigues   +3 more
wiley   +1 more source

In Vitro Screening Test Using Leishmania Promastigotes Stably Expressing mCherry Protein [PDF]

, 2014
Transgenic Leishmania major and Leishmania donovani axenic promastigotes constitutively expressing mCherry were used for in vitro antileishmanial drug screening. This method requires minimal sample manipulation and can be easily adapted to automatic drug
Miguel A. Morales, Vacchina, Paola
core   +2 more sources

In vitro and in vivo activity of meglumine antimoniate produced at Farmanguinhos-Fiocruz, Brazil, against Leishmania (Leishmania) amazonensis, L (L.) chagasi and L (Viannia) braziliensis [PDF]

Memórias do Instituto Oswaldo Cruz, 2008
The leishmanicidal activity of four batches of meglumine antimoniate, produced in Farmanguinhos-Fiocruz, Brazil (TAMs), was assessed and compared to Glucantime-Aventis Pharma Ltda. Using the amastigote-like in vitro model, the active concentrations of Sb v varied from 10microg/ml to 300microg/ml for L.
de Morais-Teixeira, Eliane, de Carvalho, Alcione S, da Costa, Jorge CS, Duarte, Silvio L, Mendonça, Jorge S, Boechat, Núbia, Rabello, Ana   +6 more
openaire   +4 more sources

How to master the host immune system? Leishmania parasites have the solutions! [PDF]

, 2017
Infection by protozoan parasites of the genus Leishmania results in the development of leishmaniasis, an increasingly prevalent group of diseases affecting over 12 million people worldwide.
Fasel, N., Rossi, M.
core   +1 more source

Benzophenone derivatives as cysteine protease inhibitors and biological activity against Leishmania(L.) amazonensis amastigotes

Biomedicine & Pharmacotherapy, 2015
The leishmanicidal potential of benzophenones has been described, some of them highlighting their potential as cysteine protease inhibitors. Therefore, this work described leishmanicidal activity of nine benzophenone derivatives (1a-c;2a-c;3a-c) against intramacrophage amastigote forms of Leishmania(L.)amazonensis (IC50) and the cytotoxic effect on ...
Letícia, de Almeida, Karina Ferreira, Alves, Claudia Mara, Maciel-Rezende, Larissa de Oliveira Passos, Jesus, Francieli Ribeiro, Pires, Claudio Viegas, Junior, Mario Augusto, Izidoro, Wagner Alves de Souza, Júdice, Marcelo Henrique, dos Santos, Marcos José, Marques   +9 more
openaire   +2 more sources

Health Benefits and Therapeutic Potential of Quercetin

Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.
Quercetin, a polyphenolic compound prevalent in many fruits, vegetables, and other dietary sources, has attracted considerable interest due to its extensive health benefits. This review examines its diverse biological properties, particularly its antioxidant and anti‐inflammatory effects. The study integrates recent scientific findings to elucidate the
Mahendra Aryal, Kim Wei Chan
wiley   +1 more source