Results 1 to 10 of about 66,398 (219)

Amazonian Phlebovirus (Bunyaviridae) potentiates the infection of Leishmania (Leishmania) amazonensis: Role of the PKR/IFN1/IL-10 axis. [PDF]

PLoS Neglected Tropical Diseases, 2019
BackgroundLeishmania parasites are transmitted to vertebrate hosts by phlebotomine sandflies and, in humans, may cause tegumentary or visceral leishmaniasis.
Carolina Torturella Rath, Laila Castro Schnellrath, Clarissa R Damaso, Luciana Barros de Arruda, Pedro Fernando da Costa Vasconcelos, Claudia Gomes, Marcia Dalastra Laurenti, Teresa Cristina Calegari Silva, Áislan de Carvalho Vivarini, Nicolas Fasel, Renata Meirelles Santos Pereira, Ulisses Gazos Lopes   +11 more
doaj   +3 more sources

Predominance of Leishmania (Leishmania) amazonensis DNA in Lutzomyia longipalpis sand flies (Diptera: Psychodidae) from an endemic area for leishmaniasis in Northeastern Brazil. [PDF]

Rev Inst Med Trop Sao Paulo, 2022
Leishmaniasis is a serious public health concern in the Northeastern region of Brazil, where the sand fly fauna is well studied, although few species have been identified as competent vectors. The detection of Leishmania spp.
Carvalho-Silva R, Ribeiro-da-Silva RC, Cruz LNPD, Oliveira MDS, Amoedo PM, Rebêlo JMM, Guimarães-E-Silva AS, Pinheiro VCS.   +7 more
europepmc   +2 more sources

Activity of alkaloids from Aspidosperma nitidum against Leishmania (Leishmania) amazonensis. [PDF]

Sci Rep, 2022
AbstractThis study evaluated the morphological changes caused by fractions and subfractions, obtained from barks of Aspidosperna nitidum, against L. (L.) amazonensis promastigotes. The ethanolic extract (EE) obtained through the maceration of trunk barks was subjected to an acid–base partition, resulting the neutral (FN) and the alkaloid (FA) fractions,
do Socorro Silva da Veiga A, Silveira FT, da Silva EO, Júnior JAPD, Araújo SC, Campos MB, do Rosário Marinho AM, Brandão GC, Vale VV, Percário S, Dolabela MF.   +10 more
europepmc   +4 more sources

Transcriptional responses of Leishmania (Leishmania) amazonensis in the presence of trivalent sodium stibogluconate. [PDF]

Parasit Vectors, 2019
In the last decade, resistance to antimonials has become a serious problem due to the emergence of drug-resistant strains. Therefore, understanding the mechanisms used by Leishmania parasites to survive under drug pressure is essential, particularly for ...
Patino LH, Muskus C, Ramírez JD.
europepmc   +2 more sources

Arginase expression modulates nitric oxide production in Leishmania (Leishmania) amazonensis

PLOS ONE, 2017
Background Arginase is an enzyme that converts L-arginine to urea and L-ornithine, an essential substrate for the polyamine pathway supporting Leishmania (Leishmania) amazonensis replication and its survival in the mammalian host.
S. M. Acuña, J. I. Aoki, M. F. Laranjeira-Silva, R. Zampieri, J. C. R. Fernandes, S. Muxel, L. Floeter-Winter   +6 more
semanticscholar   +5 more sources

Visceral leishmaniasis caused by Leishmania (Leishmania) amazonensis associated with Hodgkin's lymphoma. [PDF]

Rev Inst Med Trop Sao Paulo, 2022
Visceral leishmaniasis (VL) is mainly caused by Leishmania (Leishmania) donovani and Leishmania (L.) infantum; however, other Leishmania species have been associated with VL. We report a case of a patient simultaneously diagnosed with VL caused by Leishmania (L.) amazonensis and Hodgkin's lymphoma.
Porto VBG, Carvalho LB, Buzo BF, Litvoc MN, Santos ACS, Rocci RA, Soares SRC, Zampieri RA, Duarte MIS, Lindoso JAL.   +9 more
europepmc   +4 more sources

Dietary Vitamin D3 Deficiency Increases Resistance to Leishmania (Leishmania) amazonensis Infection in Mice. [PDF]

Front Cell Infect Microbiol, 2019
The leishmaniases are a group of diseases caused by Leishmania parasites, which have different clinical manifestations. Leishmania (Leishmania) amazonensis is endemic in South America and causes cutaneous leishmaniasis (CL), which can evolve into a ...
Bezerra IPDS, Oliveira-Silva G, Braga DSFS, de Mello MF, Pratti JES, Pereira JC, da Fonseca-Martins AM, Firmino-Cruz L, Maciel-Oliveira D, Ramos TD, Vale AM, Gomes DCO, Rossi-Bergmann B, de Matos Guedes HL.   +13 more
europepmc   +2 more sources

Sphingolipid degradation in Leishmania (Leishmania) amazonensis.

PLoS Neglected Tropical Diseases, 2012
BackgroundHuman leishmaniasis is caused by more than 20 Leishmania species and has a wide range of symptoms. Our recent studies have demonstrated the essential role of sphingolipid degradation in the virulence of Leishmania (Leishmania) major, a species ...
Agiesh Balakrishna Pillai, Wei Xu, Ou Zhang, Kai Zhang   +3 more
doaj   +3 more sources

Experimental transmission of Leishmania (Leishmania) amazonensis to immunosuppressed mice through the bite of Lutzomyia longipalpis (Diptera: Psychodidae) results in cutaneous leishmaniasis [PDF]

Revista do Instituto de Medicina Tropical de São Paulo, 2021
Lutzomyia longipalpis is the natural vector of Leishmania (Leishmania) infantum, but it is also permissive for several Leishmania species that are related to cutaneous leishmaniasis (CL). Maranhao State (Northeast of Brazil) is endemic for CL and has the
Rosa Cristina Ribeiro da Silva, Léo Nava Piorsky Dominici Cruz, João Manoel da Silva Coutinho, Carlos Eduardo Fonseca-Alves, José Manuel Macário Rebêlo, Silma Regina Ferreira Pereira   +5 more
doaj   +2 more sources

Immunization with antigenic extracts of Leishmania associated with Montanide ISA 763 adjuvant induces partial protection in BALB/c mice against Leishmania (Leishmania) amazonensis infection [PDF]

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi, 2014
Background/Purpose: A proper adjuvant has a relevant role in vaccine formulations to generate an effective immune response. In this study, total Leishmania antigen (TLA) formulated with Montanide ISA 763 or R848 as adjuvants were evaluated as a first ...
Cargnelutti, Diego Esteban, Celedon, Verónica, Cuello Carrión, Fernando Darío, Garcia Bustos, Maria Fernanda, Morea, Gastón, Salomón, María Cristina, Scodeller, Eduardo   +6 more
core   +2 more sources