Biomedicine & Pharmacotherapy, 2018 Leishmania (Leishmania) amazonensis and Leishmania infantum (=Leishmania chagasi) are protozoa that cause American cutaneous and visceral leishmaniasis, respectively. These diseases show a high incidence in developing countries such as Brazil. The treatments used for leishmaniasis are still limited due to their high cost and toxicity.
B. da Silva +5 more
semanticscholar +3 more sources
Experimental treatment with sodium stibogluconate of hamsters infected with Leishmania (Leishmania) chagasi and Leishmania (Leishmania) amazonensis [PDF]
Revista da Sociedade Brasileira de Medicina Tropical, 1999 The present paper reports the experimental treatment of hamsters infected with Leishmania chagasi and Leishmania amazonensis with sodium stibogluconate (20mg/kg/day x 20 days). Only with L.
Elizabeth M. de Figueiredo +2 more
doaj +4 more sources
Serological reactivity of different antigenic preparations of Leishmania (Leishmania) amazonensis and the Leishmania braziliensis complex Reatividade sorológica frente a diferentes preparações antigênicas de Leishmania (Leishmania) amazonensis e do complexo Leishmania braziliensis [PDF]
Revista da Sociedade Brasileira de Medicina Tropical, 2008 Total antigen from Leishmania (Leishmania) amazonensis and isolates from the Leishmania braziliensis complex, along with their respective antigenic fractions obtained by affinity chromatography on concanavalin-A-Sepharose and jacalin-agarose columns ...
Adriano Gomes-Silva +8 more
doaj +5 more sources
Resistance of Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensisto nitric oxide correlates with disease severity in Tegumentary Leishmaniasis [PDF]
BMC Infectious Diseases, 2007 Background Nitric oxide (NO•) plays a pivotal role as a leishmanicidal agent in mouse macrophages. NO• resistant Escherichia coli and Mycobacterium tuberculosis have been associated with a severe outcome of these diseases.
Angela Giudice +63 more
core +2 more sources
The Genome Sequence of Leishmania (Leishmania) amazonensis: Functional Annotation and Extended Analysis of Gene Models [PDF]
DNA Research, 2013 We present the sequencing and annotation of the Leishmania (Leishmania) amazonensis genome, an etiological agent of human cutaneous leishmaniasis in the Amazon region of Brazil. L.
Alpuche-Aranda +85 more
core +3 more sources
Acta Tropica, 2019 Leishmaniasis is a complex disease caused by Leishmania species belonging to subgenera Leishmania and Viannia. In South America, L. (L.) infantum is considered the most important causative agent of visceral leishmaniasis, while L.
A. Diotallevi +9 more
semanticscholar +4 more sources
Experimental Parasitology, 2012 Polyamine biosynthesis enzymes are promising drug targets for the treatment of leishmaniasis, Chagas' disease and African sleeping sickness. Arginase, which is a metallohydrolase, is the first enzyme involved in polyamine biosynthesis and converts arginine into ornithine and urea.
E. R. da Silva +2 more
semanticscholar +3 more sources
Leishmania amazonensis promastigotes in 3D Collagen I culture: an in vitro physiological environment for the study of extracellular matrix and host cell interactions [PDF]
PeerJ, 2014 Leishmania amazonensis is the causative agent of American cutaneous leishmaniasis, an important neglected tropical disease. Once Leishmania amazonensis is inoculated into the human host, promastigotes are exposed to the extracellular matrix (ECM) of the ...
Debora B. Petropolis +5 more
doaj +5 more sources
Microbiology resource announcements, 2019 We present here the draft genome sequences of Leishmania (Leishmania) amazonensis, Leishmania (Leishmania) mexicana, and Leishmania (Leishmania) aethiopica, potential etiological agents of diffuse cutaneous leishmaniasis (DCL).
D. Batra +7 more
semanticscholar +3 more sources
CD100/Sema4D Increases Macrophage Infection by Leishmania (Leishmania) amazonensis in a CD72 Dependent Manner [PDF]
Frontiers in Microbiology, 2018 Leishmaniasis is caused by trypanosomatid protozoa of the genus Leishmania, which infect preferentially macrophages. The disease affects 12 million people worldwide, who may present cutaneous, mucocutaneous or visceral forms.
Mariana K. Galuppo +7 more
doaj +2 more sources