Results 41 to 50 of about 66,437 (256)

Ecological Niche Modelling Predicts Southward Expansion of Lutzomyia (Nyssomyia) flaviscutellata (Diptera: Psychodidae: Phlebotominae), Vector of Leishmania (Leishmania) amazonensis in South America, under Climate Change

PLoS ONE, 2015
Vector borne diseases are susceptible to climate change because distributions and densities of many vectors are climate driven. The Amazon region is endemic for cutaneous leishmaniasis and is predicted to be severely impacted by climate change.
B. Carvalho, E. F. Rangel, P. Ready, M. M. Vale   +3 more
semanticscholar   +1 more source

Vaccination of C57BL/10 mice against cutaneous leishmaniasis using killed promastigotes of different strains and species of Leishmania Vacinação de camundongos C57BL/10 contra leishmaniose com promastigotas mortas de diferentes cepas e espécies de Leishmania

Revista da Sociedade Brasileira de Medicina Tropical, 2002
Antigenic extracts from five Leishmania stocks were used to vaccinate C57BL/10 mice. The Leishvacin® and PH8 monovalent vaccine yielded the highest IFN-gamma levels in the supernatants of spleen cell culture from vaccinated animals.
Wilson Mayrink, Gilmara Cristina dos Santos, Vicente de Paulo Coelho Peixoto de Toledo, Tânia Mara Pinto Dabés Guimarães, George Luis Lins Machado-Coelho, Odair Genaro, Carlos Alberto da Costa   +6 more
doaj   +1 more source

Role of protein kinase R in the killing of Leishmania major by macrophages in response to neutrophil elastase and TLR4 via TNF and IFN [PDF]

, 2014
In cutaneous leishmaniasis, Leishmania amazonensis activates macrophage double-stranded, RNA-activated protein kinase R (PKR) to promote parasite growth. In our study, Leishmania major grew normally in RAW cells, RAW-expressing dominant-negative PKR (PKR-
Abu-Dayyeh I., Aislan de Carvalho Vivarini, Ana Paula C. A. Lima, Da Silva R., Danelli M. G., Jeremy C. Mottram, Marilia S. Faria, Nylen S., Tereza C. Calegari‐Silva, Ulisses Gazos Lopes, Vivarini Ade C.   +10 more
core   +1 more source

Leukocyte Behavior in Mesenteric Microcirculation upon Experimental By Leishmania Spp. in BALB/c Mice

Iranian Journal of Parasitology, 2021
Background: We aimed to determine the cellular recruitment (leukocyte rolling and adhesion) by which the Leishmania (Viannia) braziliensis, L. (Leishmania) amazonensis, and L. (Leishmania) major species in the mesenteric microcirculation of BALB/c mice.
Herintha Coeto Neitzke-Abreu, Rhuan Carlos Souza Caetano, Kárin Rosi Reinhold-Castro, Manoel Sebastião da Costa Lima-Junior, Wagner José Tenório dos Santos, Gessilda de Alcantara Nogueira de Melo, Roberto Kenji Nakamura Cuman, Sandra Mara Alessi Aristides, Thais Gomes Verzignassi Silveira, Maria Valdrinez Campana Lonardoni   +9 more
doaj  

Unveiling the Leishmanicidal Mechanism of 4-Nerolidylcatechol Isolated From Piper peltatum Against Leishmania infantum. [PDF]

Chem Biodivers
ABSTRACT The present study assessed the leishmanicidal activity of 4‐nerolidylcatechol (4‐NC) (1) isolated from Piper peltatum leaves against promastigotes and amastigotes of Leishmania amazonensis, L. braziliensis, and L. infantum. The plant was fractionated, leading to the isolation and chemical identification of 4‐NC (1). Biochemical techniques were
Lorenzetti FB, Balbinot RB, Lazarin-Bidóia D, Faiões VDS, Torres-Santos EC, Nakamura CV, Ueda-Nakamura T, Garcia Cortez DA, Dias Filho BP.   +8 more
europepmc   +2 more sources

Phage-fused epitopes from Leishmania infantum used as immunogenic vaccines confer partial protection against Leishmania amazonensis infection [PDF]

, 2016
Two mimotopes of Leishmania infantum identified by phage display were evaluated as vaccine candidates in BALB/c mice against Leishmania amazonensis infection.
Coelho, Eduardo A. F., Costa, Lourena E., Soto, Manuel   +2 more
core   +1 more source

Inhibition of growth of Leishmania mexicana mexicana by Leishmania mexicana amazonensis during "in vitro" co-cultivation Inibição do crescimento de Leishmania mexicana mexicana por Leishmania mexicana amazonensis durante o co-cultivo "in vitro"

Memorias do Instituto Oswaldo Cruz, 1987
Inhibition of one Leishmania subspecies by exometabolites of another subspecies, a phenomenon not previously reported, is suggested by our recent observations in cell cloning experiments with Leishmania mexicana mexicana and Leishmania mexicana ...
Raquel S. Pacheco, Gabriel Grimaldi Júnior, Carlos M. Morel   +2 more
doaj   +1 more source

Emerging Role for the PERK/eIF2α/ATF4 in Human Cutaneous Leishmaniasis. [PDF]

, 2017
Leishmania parasites utilize adaptive evasion mechanisms in infected macrophages to overcome host defenses and proliferate. We report here that the PERK/eIF2α/ATF4 signaling branch of the integrated endoplasmic reticulum stress response (IERSR) is ...
Aktas, B.H., Calegari-Silva, T.C., Cavalcanti, Á., Dias-Teixeira, K.L., Fasel, N., Gomes, C.M., Lopes, U.G., Medina, J.M., Pereira, RMS, Real, F., Santana, AKM, Silva, J.S., Teteo, N., Vivarini, Á.C.   +13 more
core   +3 more sources

The combination therapy of meglumine antimoniate and oxiranes (epoxy-α-lapachone and epoxymethyl-lawsone) enhance the leishmanicidal effect in mice infected by Leishmania (Leishmania) amazonensis

International Journal for Parasitology: Drugs and Drug Resistance, 2019
Current treatment of cutaneous leishmaniasis includes pentavalent antimonials as first-line drugs, but this therapy has shown severe adverse effects. An alternative to minimize this issue is based on combination therapy scheme with other drugs.
Luiz Filipe Gonçalves-Oliveira, F. Souza-Silva, Luzia Monteiro de Castro Côrtes, L. B. Veloso, Bernardo Acácio Santini Pereira, L. Cysne-Finkelstein, G. Lechuga, S. Bourguignon, Fernando Almeida-Souza, Kátia da Silva Calabrese, V. Ferreira, C. R. Alves   +11 more
semanticscholar   +1 more source

Synthesis, Leishmanicidal Activity and Theoretical Evaluations of a Series of Substituted bis-2-Hydroxy-1,4-Naphthoquinones

Molecules, 2014
A series of eight substituted bis-2-hydroxy-1,4-naphthoquinone derivatives was synthesized through lawsone condensation with various aromatic and aliphatic aldehydes under mild acidic conditions.
Morgana V. de Araújo, Patricia S. O. de Souza, Aline C. de Queiroz, Carolina B. B. da Matta, Anderson Brandão Leite, Amanda Evelyn da Silva, José A. A. de França, Tania M. S. Silva, Celso A. Camara, Magna S. Alexandre-Moreira   +9 more
doaj   +1 more source