Results 1 to 10 of about 5,072 (143)
Catalase impairs Leishmania mexicana development and virulence [PDF]
Virulence, 2021 Catalase is one of the most abundant enzymes on Earth. It decomposes hydrogen peroxide, thus protecting cells from dangerous reactive oxygen species. The catalase-encoding gene is conspicuously absent from the genome of most representatives of the family Trypanosomatidae.
Jovana Sádlová +15 more
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Inhibition of growth of Leishmania mexicana mexicana by Leishmania mexicana amazonensis during "in vitro" co-cultivation [PDF]
Memórias do Instituto Oswaldo Cruz, 1987 Inhibition of one Leishmania subspecies by exometabolites of another subspecies, a phenomenon not previously reported, is suggested by our recent observations in cell cloning experiments with Leishmania mexicana mexicana and Leishmania mexicana amazonensis. Clones were identified using the technique of schizodeme analysis.
Pacheco, Raquel S. +2 more
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The DNA polymerases ofLeishmania mexicana [PDF]
FEMS Microbiology Letters, 1992 Two previously isolated DNA polymerases from the parasitic protozoan Leishmania mexicana were further characterized by exposure to inhibitors of mammalian DNA polymerases. DNA polymerase A, a high molecular mass enzyme, and DNA polymerase B, a beta-like DNA polymerase were compared to each other and to their mammalian counterparts regarding pH optimum,
Linda L. Nolan, Jose H. Rivera
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Structure of Leishmania mexicana lipophosphoglycan.
Journal of Biological Chemistry, 1992 Lipophosphoglycan (LPG) was isolated from the culture supernatant of Leishmania mexicana promastigotes and its structure elucidated by a combination of 1H NMR, fast atom bombardment mass spectrometry, methylation analysis, and chemical and enzymatic modifications. It consists of the repeating phosphorylated oligosaccharides PO4-6Gal beta 1-4Man alpha 1-
Ilg, Thomas +7 more
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Endocytosis and Sphingolipid Scavenging inLeishmania mexicanaAmastigotes [PDF]
Biochemistry Research International, 2012 Leishmaniaspecies are the causative agents of the leishmaniases, a spectrum of neglected tropical diseases. Amastigote stage parasites exist within macrophages and scavenge host factors for survival, for example,Leishmaniaspecies utilise host sphingolipid for synthesis of complex sphingolipid. In this studyL.
Ali, Hayder Z. +2 more
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Stage-specific proteinases ofLeishmania mexicana mexicanapromastigotes [PDF]
FEMS Microbiology Letters, 1992 Four distinct bands of cysteine proteinase activity were detected when stationary-phase populations of Leishmania mexicana mexicana were subjected to gelatin-SDS-PAGE. The highest mobility band contained at least three isoforms separable by mono Q anion exchange chromatography.
Graham H. Coombs, Colin D. Robertson
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Vaccination with Leishmania mexicana LPG induces PD-1 in CD8+ and PD-L2 in macrophages thereby suppressing the immune response: A model to assess vaccine efficacy [PDF]
Vaccine Volume 32, Issue 11, 5 March 2014, Pages 1259-1265, 2019 Leishmania lipophosphoglycan is a molecule that has been used as a vaccine candidate, with contradictory results. Since unsuccessful protection could be related to suppressed T cell responses, we analyzed the expression of inhibitory receptor PD-1 in CD8+ and CD4+ lymphocytes and it is ligand PD-L2 in macrophages of BALB/c mice immunized with various ...
arxiv +1 more source
Leishmania mexicana infection of the eyelid in a traveler to Belize [PDF]
Brazilian Journal of Infectious Diseases, 2006 A 50 year-old man, a United States resident, presented in Texas with a violaceous non-ulcerating lesion, involving the entire lower eyelid. The patient had traveled to a jungle area of Belize several hours drive from the capital city. Leishmania mexicana was isolated.
Joseph M. Vinetz, Lynn Soong
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Proteomic analysis of Leishmania mexicana differentiation
Molecular and Biochemical Parasitology, 2004 We have resolved the proteome of axenically differentiated Leishmania mexicana parasites by two-dimensional gel electrophoresis (2DE), employing optimised, robust and reproducible procedures, and visualised (by silver staining) approximately 2000 protein species in each of three developmental stages: procyclic promastigotes, metacyclic promastigotes ...
Nugent, P +4 more
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In vitro and in vivo antileishmanial efficacy of a combination therapy of diminazene and artesunate against Leishmania donovani in BALB /c mice [PDF]
Rev. Inst. Med. Trop. Sao Paulo. 2011, 53 (3): 129 - 132, 2011 The in vitro and in vivo activity of diminazene (Dim), artesunate (Art) and combination of Dim and Art (Dim-Art) against Leishmania donovani was compared to reference drug; amphotericin B. IC50 of Dim-Art was found to be $2.28 \pm 0.24 \mu$ g/mL while those of Dim and Art were $9.16 \pm 0.3 \mu$ g/mL and $4.64 \pm 0.48 \mu$ g/mL respectively.
arxiv +1 more source