Parasite excretory-secretory products and their effects on metabolic syndrome [PDF]
, 2017 Obesity, one of the main causes of metabolic syndrome (MetS), is an increasingly common health and economic problem worldwide, and one of the major risk factors for developing type 2 diabetes and cardiovascular disease. Chronic, low-grade inflammation is
Crowe, J. +3 more
core +2 more sources
Boundary behaviours of Leishmania mexicana: a hydrodynamic simulation study [PDF]
, 2018 It is well established that the parasites of the genus Leishmania exhibit complex surface interactions with the sandfly vector midgut epithelium, but no prior study has considered the details of their hydrodynamics. Here, the boundary behaviours of motile Leishmania mexicana promastigotes are explored in a computational study using the boundary element
arxiv +1 more source
The Genomic Signature of Crop-Wild Introgression in Maize [PDF]
PLoS Genetics 2013 9(5): e1003477, 2012 The evolutionary significance of hybridization and subsequent introgression has long been appreciated, but evaluation of the genome-wide effects of these phenomena has only recently become possible. Crop-wild study systems represent ideal opportunities to examine evolution through hybridization.
arxiv +1 more source
Structures, targets and recent approaches in anti-leishmanial drug discovery and development. [PDF]
, 2011 Recent years have seen a significant improvement in available treatment options for leishmaniasis. Two new drugs, miltefosine and paromomycin, have been registered for the treatment of visceral leishmaniasis (VL) in India since 2002.
Seifert, Karin
core +2 more sources
Estimating the concentration of gold nanoparticles incorporated on Natural Rubber membranes using Multi-Level Starlet Optimal Segmentation [PDF]
J Nanopart Res (2014) 16: 2809, 2016 This study consolidates Multi-Level Starlet Segmentation (MLSS) and Multi-Level Starlet Optimal Segmentation (MLSOS), techniques for photomicrograph segmentation that use starlet wavelet detail levels to separate areas of interest in an input image.
arxiv +1 more source
The Leishmania major BBSome subunit BBS1 is essential for parasite virulence in the mammalian host [PDF]
, 2013 Bardet–Biedl syndrome (BBS) is a human genetic disorder with a spectrum of symptoms caused by primary cilium dysfunction. The disease is caused by mutations in one of at least 17 identified genes, of which seven encode subunits of the BBSome, a protein ...
Doehl, Johannes +6 more
core +1 more source
IgG1 Is Pathogenic in Leishmania mexicana Infection [PDF]
The Journal of Immunology, 2010 Abstract There are >2 million new cases of leishmaniasis annually, and no effective vaccine has been developed to prevent infection. In murine infection, Leishmania mexicana, which lives intracellularly in host macrophages, has developed pathways to hijack host IgG to induce a suppressive IL-10 response through FcγRs, the cell ...
Niansheng Chu +4 more
openaire +3 more sources
The TLR2/6 ligand PAM2CSK4 is a Th2 polarizing adjuvant in Leishmania major and Brugia malayi murine vaccine models. [PDF]
, 2016 Toll-like receptors (TLRs) play an important role in the innate and adaptive immune responses to pathogens, and are the target of new vaccine adjuvants.
Bates, PA +4 more
core +6 more sources
Automated identification of flagella from videomicroscopy via the medial axis transform [PDF]
, 2018 Ubiquitous in eukaryotic organisms, the flagellum is a well-studied organelle that is well-known to be responsible for motility in a variety of organisms. Commonly necessitated in their study is the capability to image and subsequently track the movement of one or more flagella using videomicroscopy, requiring digital isolation and location of the ...
arxiv +1 more source
The recombinant cysteine proteinase B (CPB) from Leishmania braziliensis and its domains: promising antigens for serodiagnosis of cutaneous and visceral leishmaniasis in dogs. [PDF]
, 2019 Leishmaniasis represents a group of parasitic diseases caused by a protozoan of the genus Leishmania and is widely distributed in tropical and subtropical regions.
Basombrío, Manuel Alberto +10 more
core +1 more source