Results 31 to 40 of about 13,441 (240)

Compressed AFM-IR hyperspectral nanoimaging of single Leishmania parasites [PDF]

arXiv, 2022
Infrared hyperspectral imaging is a powerful approach in the field of materials and life sciences. However, the extension to modern sub-diffraction nanoimaging still remains a highly inefficient technique, as it acquires data via inherent sequential schemes.
arxiv  

Activity of Hydroxyurea against Leishmania mexicana [PDF]

Antimicrobial Agents and Chemotherapy, 2008
ABSTRACT Leishmania mexicana is a protozoan parasite that causes a disease in humans with frequent relapses after treatment. It is also highly resistant to the currently available drugs. For this reason, there is an urgent need for more effective antileishmanial drugs.
Hugo Martínez-Rojano, Norma Galindo-Sevilla, Javier Mancilla-Ramírez, Laura Quiñonez-Diaz, Laura Quiñonez-Diaz   +4 more
openaire   +3 more sources

Mathematical-Physics of propagating modes in planar waveguides [PDF]

Revista Mexicana de F\'isica E 65, 218-222 (2019), 2019
In this paper we present a detailed physical analysis of the formation of the propagation transverse modes in planar dielectric waveguides using a mathematical-physics approach. We demonstrate physically that, at the wavelength scale, the pure stationary mode inside planar waveguide is described by the cosine function.
arxiv   +1 more source

Integration of Machine Learning‐QSAR and Polypharmacology in Drug Discovery for Leishmaniasis Using Natural and Repurposed Compounds

ChemistrySelect, Volume 10, Issue 21, June 4, 2025.
Leishmaniasis affects over 1 billion people worldwide, with current treatments limited by toxicity and efficacy. This study used machine learning (ML), QSAR, and polypharmacology to identify potential drug candidates, analyzing 12,072 compounds with random forest and XGBoost models.
Laís Salvador do Amaral, Amiel Artur Morais, Alexandre de Fátima Cobre, Raul Edison Luna Lazo, Dile Pontarolo Stremel, Jaqueline Carneiro, Luana Mota Ferreira, Roberto Pontarolo   +7 more
wiley   +1 more source

Leishmania mexicana mexicana: quantitative analysis of the intracellular cycle

Parasitology, 1989
SummaryThe complete intracellular cycle of theLeishmania mexicana mexicanaG. S. strain was quantified in human macrophages and in the mouse IC-21 macrophage line utilizing a culture system that allows the direct observation of individual intracellular parasites.
James A. Dvorak, A. A. Gam, P. S. Doyle, Juan C. Engel   +3 more
openaire   +3 more sources

De-novo design of complementary (antisense) peptide mini-receptor inhibitor of interleukin 18 (IL-18).

, 2004
Complementary (antisense) peptide mini-receptor inhibitors are complementary peptides designed to be receptor-surrogates that act by binding to selected surface features of biologically important proteins thereby inhibiting protein-cognate receptor ...
Bhakoo, Ashish, Heal, Jonathan R, Keller, Michael, Miller, Andrew D, Raynes, John G   +4 more
core   +1 more source

Colonisation resistance in the sand fly gut:Leishmania protects Lutzomyia longipalpis from bacterial infection [PDF]

, 2014
BACKGROUND: Phlebotomine sand flies transmit the haemoflagellate Leishmania, the causative agent of human leishmaniasis. The Leishmania promastigotes are confined to the gut lumen and are exposed to the gut microbiota within female sand flies.
Aguiar-Martins, Kelsilândia, Al Salem, Waleed S., Bates, Paul A., Cavalcante, Reginaldo R., Diaz-Albiter, Hector, Dillon, Rod J., Dillon, Viv M., Genta, Fernando A., Sant'Anna, Mauricio R. V.   +8 more
core   +3 more sources

In Silico Prediction and Validation of LmGt Inhibitors Using QSAR and Molecular Docking Approaches [PDF]

Proceedings of the 2025 IEEE International Conference on Innovation in Computing and Engineering (ICE), Greater Noida, India, pp. 1 to 5, 2025
Leishmaniasis caused by Leishmania mexicana relies on Leishmania mexicana gluscose transporter (LmGT) receptors, which play an important role in glucose and ribose uptake at different stages of parasite's life cycle. Previous efforts to identify LmGT inhibitors have been primarily based on in vitro screening.
arxiv   +1 more source

Profiling Serine Hydrolases in the Leishmania Host–Pathogen Interactome Using Cell‐Permeable Activity‐Based Fluorophosphonate Probes

ChemBioChem, Volume 26, Issue 10, May 27, 2025.
Leishmaniasis poses a global health challenge with limited treatment options and rising drug resistance. Activity‐based protein profiling using fluorophosphonate probes is employed to profile serine hydrolases, key virulence factors in Leishmania mexicana.
Jaime A. Isern, Exequiel O. J. Porta, Karunakaran Kalesh, Zisis Koutsogiannis, Davide Cazzola, Ehmke Pohl, Paul W. Denny, Patrick G. Steel   +7 more
wiley   +1 more source

The Inactive X Chromosome: A Genetic Driver of Female‐Biased Rheumatic Autoimmune Disorders?

European Journal of Immunology, Volume 55, Issue 5, May 2025.
Recent works indicate that several X‐linked genetic mechanisms contribute to the female predisposition for autoimmune diseases. Here, we review the recent findings that underscore the significance of the alteration of X chromosome inactivation (XCI) maintenance and the putative role of the long noncoding XIST/Xist RNA in this process but also as a sex ...
Léa Ferrayé, Mélissa Nieucel, Magali Savignac, Julie Chaumeil, Jean‐Charles Guéry   +4 more
wiley   +1 more source