Results 41 to 50 of about 13,441 (240)

Role of protein kinase R in the killing of Leishmania major by macrophages in response to neutrophil elastase and TLR4 via TNF and IFN [PDF]

, 2014
In cutaneous leishmaniasis, Leishmania amazonensis activates macrophage double-stranded, RNA-activated protein kinase R (PKR) to promote parasite growth. In our study, Leishmania major grew normally in RAW cells, RAW-expressing dominant-negative PKR (PKR-
Abu-Dayyeh I., Aislan de Carvalho Vivarini, Ana Paula C. A. Lima, Da Silva R., Danelli M. G., Jeremy C. Mottram, Marilia S. Faria, Nylen S., Tereza C. Calegari‐Silva, Ulisses Gazos Lopes, Vivarini Ade C.   +10 more
core   +1 more source

Neuroimmune Pain and Its Manipulation by Pathogens

Evolutionary Applications, Volume 18, Issue 4, April 2025.
ABSTRACT Recent studies highlight extensive crosstalk that exists between sensory neurons responsible for pain and the immune system. Cutaneous pain neurons detect harmful microbes, recruit immune cells, and produce anticipatory immunity in nearby tissues. These complementary systems generally protect hosts from infections.
Kevin W. Lozo, Athena Aktipis, Joe Alcock   +2 more
wiley   +1 more source

Mating disruption of citrus leafminer mediated by a noncompetitive mechanism at a remarkably low pheromone release rate.

, 2008
The citrus leafminer, Phyllocnistis citrella Stainton (Lepidoptera: Gracillariidae), is a worldwide pest of citrus. A season-long investigation was conducted that evaluated mating disruption for this pest. Effective disruption of the male P.
Miller, JR, Rogers, ME, Stelinski, LL
core   +1 more source

Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs. [PDF]

, 2013
OBJECTIVES: Trypanosoma brucei drug transporters include the TbAT1/P2 aminopurine transporter and the high-affinity pentamidine transporter (HAPT1), but the genetic identity of HAPT1 is unknown. We recently reported that loss of T.
Aguinaga Andrés, David, Baker, Nicola, Barrett, Michael P, Burchmore, Richard JS, Clucas, Caroline, De Koning, Harry P, Eze, Anthonius A, Glover, Lucy, Graf, Fabrice E, Horn, David, Lee, Rebecca S, Ludin, Philipp, MacLeod, Annette, McDonald, Jennifer, Munday, Jane C, Mäser, Pascal, Natto, Manal J, Tait, Andy, Teka, Ibrahim A, Turner, C Michael R   +19 more
core   +3 more sources

LOPAC library screening identifies suramin as a TRIM21 binder with a unique binding mode revealed by crystal structure

Acta Crystallographica Section F, Volume 81, Issue 3, Page 101-107, March 2025.
This communication describes the crystal structure of TRIM21 in complex with suramin, providing new opportunities to target this E3 ligase.Differential scanning fluorimetry screening of the Library of Pharmacologically Active Compounds (LOPAC) identified four hits for the PRYSPRY domain of the human E3 ligase tripartite motif‐containing protein 21 ...
Yeojin Kim, Stefan Knapp, Andreas Krämer   +2 more
wiley   +1 more source

The proinflammatory activity of recombinant serum amyloid A is not shared by the endogenous protein in the circulation.

, 2010
OBJECTIVE: Elevated serum levels of the acute-phase protein serum amyloid A (SAA) are a marker for active rheumatoid arthritis (RA), and SAA can also be found in the tissues of patients with active RA.
Björkman, Lena, Bylund, Johan, Dahlgren, Claes, Karlsson, Anna, Raynes, John G, Shah, Chandrabala   +5 more
core   +1 more source

Efficacy of Thermotherapy to Treat Cutaneous Leishmaniasis Caused by Leishmania tropica in Kabul, Afghanistan: A Randomized, Controlled Trial [PDF]

, 2005
BACKGROUND: Pentavalent antimony is the agent recommended for treatment of cutaneous leishmaniasis (CL). Its use is problematic, because it is expensive and because of the potential for drug-associated adverse effects during a lengthy and painful ...
Aram H, Arana BA, Babajev KB, Berman JD, Berman JD, C. R. Davies, J. Kolaczinski, J. R. David, Junaid AJN, M. Bismullah, M. Mohsen, M. Wahid, Navin TR, Neva FA, Noyes H, R. J. Quinnell, R. Reithinger, Reithinger R, Rodriguez ME, Sacks DL, Sharquie KE, Tallab TM, Velasco-Castrejon O, World Health Organization   +23 more
core   +1 more source

Unveiling the Interplay Between Dendritic Cells and Natural Killer Cells as Key Players in Leishmania Infection

Journal of Immunology Research, Volume 2025, Issue 1, 2025.
Leishmaniasis is a group of parasitic diseases whose etiological agent is the protozoa Leishmania. These diseases afflict impoverished populations in tropical and subtropical regions and affect wild and domestic animals. Canine leishmaniasis is a global disease mostly caused by L. infantum.
Ana Valério-Bolas, Mafalda Meunier, Armanda Rodrigues, Joana Palma-Marques, Rui Ferreira, Inês Cardoso, Lis Lobo, Marta Monteiro, Telmo Nunes, Ana Armada, Wilson T. Antunes, Graça Alexandre-Pires, Isabel Pereira da Fonseca, Gabriela Santos-Gomes, Rahul Shivahare   +14 more
wiley   +1 more source

Cellular landmarks of Trypanosoma brucei and Leishmania mexicana

Molecular and Biochemical Parasitology, 2019
The kinetoplastids Trypanosoma brucei and Leishmania mexicana are eukaryotes with a highly structured cellular organisation that is reproduced with great fidelity in each generation. The pattern of signal from a fluorescently tagged protein can define the specific structure/organelle that this protein localises to, and can be extremely informative in ...
Clare Halliday, Jack D. Sunter, Karen Billington, Samuel Dean, Richard J. Wheeler, Ziyin Wang, Ross Madden   +6 more
openaire   +4 more sources

Aislantes Topológicos [PDF]

Bol. Soc. Mex. F\'{i}s. 33, 1 (2019), 2020
We present a brief introduction to the topological phases of matter.
arxiv