Results 51 to 60 of about 8,190 (198)

Leishmania mexicana potential drug target

The FASEB Journal, 2012
We have been studying the Leishmania mexicana protein kinase Lmx‐MPK1. Lmx‐MPK1 is required for parasite viability in the host and represents a potential therapeutic target. We have been studying the interaction of the human p38 mitogen‐activated protein kinase (p38 MAPK) inhibitor, BIRB 796, with Lmx‐ MPK1.
Tamara Kreiss, Seema J Patel, Nina Goodey, John J Siekierka, Aysenur Sayakci   +4 more
openaire   +1 more source

Different Derivatives of Plumbagin Analogue: Bioavailability and Their Toxicity Studies

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
Plumbagin, discovered in Plumbago zeylanica, has potential therapeutic effects such as anticancer, antimicrobial, and anti‐inflammatory characteristics. It has traditionally been used to treat anemia and rheumatic pain, but its therapeutic application is limited because of low bioavailability and toxicity risk factors.
Souparnika Thekkumkara, Arenbenla Longchar, Baskar Venkidasamy, Benod Kumar Kondapavuluri, Muthu Thiruvengadam, Mansour Ghorbanpour, Sathianarayanan Sankaran   +6 more
wiley   +1 more source

IL‐12 and IFN‐γ in Response to Leishmania Infantum Antigens in Felines From an Endemic Area for Visceral Leishmaniasis

Parasite Immunology, Volume 47, Issue 8, August 2025.
ABSTRACT Visceral leishmaniasis is a potentially fatal zoonosis with an increasing incidence. Most infected felines present the disease in its subclinical form and demonstrate greater resistance to parasitemia than dogs. However, the role of cellular immunity in felines is still poorly understood. This study measured serum levels of interleukin (IL)‐12
João Victor Lé Lode, Lucas Takeshi Siqueira Ito, Gisele Mitsue Umino, Valéria Marçal Felix de Lima   +3 more
wiley   +1 more source

Visceral Leishmaniosis caused by Leishmania (L.) mexicana in a Mexican patient with human immunodeficiency virus infection

Memorias do Instituto Oswaldo Cruz, 2000
A 36 year old male was admitted in December 1997 to hospital with afternoon fever, malaise and hepatosplenomegaly. He also had a dry cough, dyspnoea and anaemia.
Carmen Ramos-Santos, Omar Hernandez-Montes, Gustavo Sanchez-Tejeda, Amalia Monroy-Ostria   +3 more
doaj   +1 more source

A novel approach for feline sporotrichosis pathogen detection based on loop‐mediated isothermal amplification

Veterinary Dermatology, Volume 36, Issue 4, Page 474-484, August 2025.
Background – Sporotrichosis is a chronic, mycotic infection caused by fungi of the genus Sporothrix. Zoonotic sporotrichosis occurs mainly through S. brasiliensis transmission, resulting from the organism's traumatic introduction via scratches or bites, or contact with exudate from contaminated cats.
Steffanie Amadei, Júlia Campos, Amanda Bertão‐Santos, Alis Frentzel, Hugo Ávila, Fabiana S. Monti, Marconi R. Farias   +6 more
wiley   +1 more source

Integration of Machine Learning‐QSAR and Polypharmacology in Drug Discovery for Leishmaniasis Using Natural and Repurposed Compounds

ChemistrySelect, Volume 10, Issue 21, June 4, 2025.
Leishmaniasis affects over 1 billion people worldwide, with current treatments limited by toxicity and efficacy. This study used machine learning (ML), QSAR, and polypharmacology to identify potential drug candidates, analyzing 12,072 compounds with random forest and XGBoost models.
Laís Salvador do Amaral, Amiel Artur Morais, Alexandre de Fátima Cobre, Raul Edison Luna Lazo, Dile Pontarolo Stremel, Jaqueline Carneiro, Luana Mota Ferreira, Roberto Pontarolo   +7 more
wiley   +1 more source

Analysis of Kinetoplast DNA from Mexican Isolates of Leishmania (L.) mexicana

Interdisciplinary Perspectives on Infectious Diseases, 2012
This study analyzed DNA minicircles of Mexican isolates of L. (Leishmania) mexicana to look for genetic differences between strains isolated from patients with diffuse cutaneous (DCL) and localized (LCL) leishmaniasis.
Omar Hernández-Montes, Saúl González Guzmán, Federico Martínez Gómez, Douglas C. Barker, Amalia Monroy-Ostria   +4 more
doaj   +1 more source

Prevalence of Leishmania species among patients with cutaneous leishmaniasis in Qassim province of Saudi Arabia

BMC Public Health, 2019
Background Leishmaniasis is a parasitic infection endemic in more than ninety countries of the world. The cutaneous leishmaniasis (CL) is a most common form of leishmaniasis and it remains to be a major public health issue in Saudi Arabia. This study was
Zafar Rasheed, Ahmed A. Ahmed, Tarek Salem, Mohammed S. Al-Dhubaibi, Ahmad A. Al Robaee, Abdullateef A. Alzolibani   +5 more
doaj   +1 more source

Profiling Serine Hydrolases in the Leishmania Host–Pathogen Interactome Using Cell‐Permeable Activity‐Based Fluorophosphonate Probes

ChemBioChem, Volume 26, Issue 10, May 27, 2025.
Leishmaniasis poses a global health challenge with limited treatment options and rising drug resistance. Activity‐based protein profiling using fluorophosphonate probes is employed to profile serine hydrolases, key virulence factors in Leishmania mexicana.
Jaime A. Isern, Exequiel O. J. Porta, Karunakaran Kalesh, Zisis Koutsogiannis, Davide Cazzola, Ehmke Pohl, Paul W. Denny, Patrick G. Steel   +7 more
wiley   +1 more source

The Inactive X Chromosome: A Genetic Driver of Female‐Biased Rheumatic Autoimmune Disorders?

European Journal of Immunology, Volume 55, Issue 5, May 2025.
Recent works indicate that several X‐linked genetic mechanisms contribute to the female predisposition for autoimmune diseases. Here, we review the recent findings that underscore the significance of the alteration of X chromosome inactivation (XCI) maintenance and the putative role of the long noncoding XIST/Xist RNA in this process but also as a sex ...
Léa Ferrayé, Mélissa Nieucel, Magali Savignac, Julie Chaumeil, Jean‐Charles Guéry   +4 more
wiley   +1 more source