Results 61 to 70 of about 8,190 (198)

A canine model of experimental infection with Leishmania (L.) mexicana

Parasites & Vectors, 2014
Background Cutaneous leishmaniasis is a tropical disease affecting over one million patients annually and Leishmania (L.) mexicana is one of the major etiological agents in the Americas. Here we established the first experimental infection of L.
Julio Vladimir Cruz-Chan, Amarú del Carmen Aguilar-Cetina, Liliana Estefanía Villanueva-Lizama, Pedro Pablo Martínez-Vega, Maria Jesús Ramírez-Sierra, Miguel Enrique Rosado-Vallado, José Leonardo Guillermo-Cordero, Eric Dumonteil   +7 more
doaj   +1 more source

The susceptibility of wild caught sand flies to infection by a subspecies of Leishmania mexicana isolated from proechimys iheringi denigratus (Rodentia, echimyidae)

Memorias do Instituto Oswaldo Cruz, 1986
Several species of wild caught sand flies were collected in the same site where a subspecies of leishmania mexicana was isolated from the rodent Proechimys iheringi denigratus.
Air C. Barretto, Julio A. Vexenat, Norman E. Peterson   +2 more
doaj   +1 more source

Neuroimmune Pain and Its Manipulation by Pathogens

Evolutionary Applications, Volume 18, Issue 4, April 2025.
ABSTRACT Recent studies highlight extensive crosstalk that exists between sensory neurons responsible for pain and the immune system. Cutaneous pain neurons detect harmful microbes, recruit immune cells, and produce anticipatory immunity in nearby tissues. These complementary systems generally protect hosts from infections.
Kevin W. Lozo, Athena Aktipis, Joe Alcock   +2 more
wiley   +1 more source

Preliminary study towards a novel experimental model to study localized cutaneous leishmaniasis caused bY Leishmania (Leishmania) mexicana

Revista do Instituto de Medicina Tropical de São Paulo, 2012
There is not an experimental model of localized cutaneous leishmaniasis (LCL) caused by Leishmania (Leishmania) mexicana. The aim of the present study was to characterize the clinical and histological features of Peromyscus yucatanicus experimentally ...
Erika Ivett Sosa-Bibiano, Nicole Raymonde Van Wynsberghe, Silvia Beatriz Canto-Lara, Fernando Jose Andrade-Narvaez   +3 more
doaj   +1 more source

LOPAC library screening identifies suramin as a TRIM21 binder with a unique binding mode revealed by crystal structure

Acta Crystallographica Section F, Volume 81, Issue 3, Page 101-107, March 2025.
This communication describes the crystal structure of TRIM21 in complex with suramin, providing new opportunities to target this E3 ligase.Differential scanning fluorimetry screening of the Library of Pharmacologically Active Compounds (LOPAC) identified four hits for the PRYSPRY domain of the human E3 ligase tripartite motif‐containing protein 21 ...
Yeojin Kim, Stefan Knapp, Andreas Krämer   +2 more
wiley   +1 more source

Cutaneous Leishmaniasis Mimicking a Nasal Tumor: A Case Report

Case Reports in Infectious Diseases, Volume 2025, Issue 1, 2025.
Leishmaniasis is a disease caused by Leishmania protozoa that is transmitted to the patient by sand flies. Depending on the Leishmania species, the disease can present with cutaneous, mucosal, or multiorgan involvement. Cutaneous leishmaniasis can present with diverse clinical manifestations mimicking other diseases.
Maryam Hekmat, Mohammad Reza Namazi, Amir Hossein Najibi, Babak Shirazi Yeganeh, Negin Fazelzadeh Haghighi, Larry M. Bush   +5 more
wiley   +1 more source

Miltefosine Failure and Amphotericin B Success in the Treatment of a Case of Cutaneous Leishmania Braziliensis in a Recent Traveler in Belize and Guatemala

Case Reports in Infectious Diseases, Volume 2025, Issue 1, 2025.
We report the case of a 53‐year‐old male with recent travel to Guatemala and Belize who was diagnosed with cutaneous leishmaniasis (CL). He was treated empirically with miltefosine with no improvement and switched to amphotericin B upon species identification of L. braziliensis, resulting in the resolution of his lesions.
Michelle Y. Ko, Emilie Fowler, Amanda Scott, Daniel Z. Uslan, Rajib Chowdhury   +4 more
wiley   +1 more source

PubChem BioAssays 1063: A Poorly Exploited Source of New Antileishmanial Compounds

Journal of Parasitology Research
PubChem Bioassays (AID 1063) reported the in vitro testing of 196,141 compounds against Leishmania major promastigotes. Although these results have been publicly available since 2008, limited efforts on further testing of some of these compounds has been
Sergio Sifontes-Rodríguez, Susana Meneses-Gómez, Alma Reyna Escalona-Montaño, Daniel Andrés Sánchez-Almaraz, Ofelia Pérez-Olvera, Aranza Regina Cañón Rosas, Pedro Zuriel Cruz Bautista, María Magdalena Aguirre-García   +7 more
doaj   +1 more source

Mucocutaneous Leishmaniasis With Oral Involvement: A Case Report

Case Reports in Dentistry, Volume 2025, Issue 1, 2025.
The primary objective of the present study is the retrospective analysis of a clinical case of oral leishmaniasis treated at Parma Hospital and a review of the literature on mucosal leishmaniasis (ML) with oral cavity involvement. We report the case of a patient diagnosed in 2017 with mucocutaneous leishmaniasis who was referred to our clinic due to ...
Pierpaolo De Francesco, Paolo Vescovi, Claudio Feliciani, Roberta Iaria, Luigi Corcione, Ilaria Giovannacci, Vlaho Brailo   +6 more
wiley   +1 more source

Evaluación del efecto del ácido nalidíxico, ampicilina, kanamicina, penicilina G y polimixina B en los cultivos de promastigotes de leishmania

Biomédica: revista del Instituto Nacional de Salud, 1992
Se evaluó el efecto de diferentes concentraciones de ácido nalidíxico, ampicilina, kanarnicina, penicilina G y polimixina B, sobre la población de promastigotes de Leishmania braziliensis braziliensis , Leishmania donovani chagasi y Leishmania mexicana ...
Sofía Duque Beltrán, Augusto Corredor Arjona, Marleny Montilla Moreno, Dioselina Peláez Carvajal   +3 more
doaj   +1 more source