Results 71 to 80 of about 15,700 (261)

Effects of TcFLA‐1BP and TcGP72 Deletion on the Infectivity and Survival of Trypanosoma cruzi in Cell Cultures

Cell Biology International, Volume 49, Issue 11, Page 1395-1410, November 2025.
ABSTRACT Chagas disease, caused by the protozoan Trypanosoma cruzi, is a neglected tropical disease with limited treatment options and no available vaccine. Understanding the role of proteins in the parasite's biological cycle is critical for advancing vaccine development and optimizing therapies.
Normanda Souza‐Melo, Giovanna Henriques de Souza, Wanderley de Souza   +2 more
wiley   +1 more source

Cloning and expression of codon-optimized recombinant darbepoetin alfa in Leishmania tarentolae T7-TR [PDF]

, 2016
Darbepoetin alfa is an engineered and hyperglycosylated analog of recombinant human erythropoietin (EPO) which is used as a drug in treating anemia in patients with chronic kidney failure and cancer.
Fard-Esfahani, P., Golavar, R., Khajeniazi, S., Kianmehr, A., Mahrooz, A., Mostafavi, S.S., Oladnabi, M., Omidinia, E., Rouintan, M.   +8 more
core   +1 more source

Complete Resolution of Cutaneous Leishmaniasis With a Novel Topical Combination Therapy: A Case Series

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Cutaneous leishmaniasis (CL) remains a therapeutic challenge in endemic regions, with 600,000–1 million new cases annually facing limited treatment options. We present a case series evaluating an innovative topical combination therapy for acute‐phase CL in Shiraz, Iran.
Hoda Haghshenas, Aref Ghanaatpisheh, Mohammad Darayesh, Elaheh Entezar Almahdi   +3 more
wiley   +1 more source

Leishmania mexicana potential drug target

The FASEB Journal, 2012
We have been studying the Leishmania mexicana protein kinase Lmx‐MPK1. Lmx‐MPK1 is required for parasite viability in the host and represents a potential therapeutic target. We have been studying the interaction of the human p38 mitogen‐activated protein kinase (p38 MAPK) inhibitor, BIRB 796, with Lmx‐ MPK1.
Tamara Kreiss, Seema J Patel, Nina Goodey, John J Siekierka, Aysenur Sayakci   +4 more
openaire   +1 more source

Production of the Antimicrobial Roseoflavin With Genetically Engineered Corynebacterium glutamicum

Microbial Biotechnology, Volume 18, Issue 10, October 2025.
Corynebacterium glutamicum was genetically engineered for the production of the riboflavin analog roseoflavin, while minimising its antimicrobial effects. To this end, the genetic machinery from the natural roseoflavin producer Streptomyces davaonensis was evaluated in a riboflavin‐producing C. glutamicum strain.
Luciana Fernandes Brito, Ane Bræin Aas, Rosa Jodalen Rudberg, Trygve Brautaset, Fernando Pérez‐García   +4 more
wiley   +1 more source

In Situ Evaluation of Macrophage Populations and Inflammasome Components in Cutaneous and Mucocutaneous Leishmaniasis

Parasite Immunology, Volume 47, Issue 9, September 2025.
ABSTRACT American tegumentary leishmaniasis (ATL) affects the skin and mucous membranes, with a spectrum shaped by Th1/Th2 responses. This study investigated inflammasome activation in correlation with macrophage subpopulations, tissue parasitism, and histological changes in cutaneous and mucocutaneous leishmaniasis. We assessed inflammasome activation,
Caroline de Heleno Chagas de Carvalho, Gabriela Venicia Araujo Flores, Carmen Maria Sandoval Pacheco, Vania Lucia da Ribeiro da Matta, Carolina de Esteves de Morais, Ricardo Romiti, Walter Belda Júnior, Márcia Dalastra Laurenti   +7 more
wiley   +1 more source

Visceral Leishmaniosis caused by Leishmania (L.) mexicana in a Mexican patient with human immunodeficiency virus infection

Memorias do Instituto Oswaldo Cruz, 2000
A 36 year old male was admitted in December 1997 to hospital with afternoon fever, malaise and hepatosplenomegaly. He also had a dry cough, dyspnoea and anaemia.
Carmen Ramos-Santos, Omar Hernandez-Montes, Gustavo Sanchez-Tejeda, Amalia Monroy-Ostria   +3 more
doaj   +1 more source

Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs. [PDF]

, 2013
OBJECTIVES: Trypanosoma brucei drug transporters include the TbAT1/P2 aminopurine transporter and the high-affinity pentamidine transporter (HAPT1), but the genetic identity of HAPT1 is unknown. We recently reported that loss of T.
Aguinaga Andrés, David, Baker, Nicola, Barrett, Michael P, Burchmore, Richard JS, Clucas, Caroline, De Koning, Harry P, Eze, Anthonius A, Glover, Lucy, Graf, Fabrice E, Horn, David, Lee, Rebecca S, Ludin, Philipp, MacLeod, Annette, McDonald, Jennifer, Munday, Jane C, Mäser, Pascal, Natto, Manal J, Tait, Andy, Teka, Ibrahim A, Turner, C Michael R   +19 more
core   +4 more sources

Different Derivatives of Plumbagin Analogue: Bioavailability and Their Toxicity Studies

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
Plumbagin, discovered in Plumbago zeylanica, has potential therapeutic effects such as anticancer, antimicrobial, and anti‐inflammatory characteristics. It has traditionally been used to treat anemia and rheumatic pain, but its therapeutic application is limited because of low bioavailability and toxicity risk factors.
Souparnika Thekkumkara, Arenbenla Longchar, Baskar Venkidasamy, Benod Kumar Kondapavuluri, Muthu Thiruvengadam, Mansour Ghorbanpour, Sathianarayanan Sankaran   +6 more
wiley   +1 more source

Local Skin Inflammation in Cutaneous Leishmaniasis as a Source of Variable Pharmacokinetics and Therapeutic Efficacy of Liposomal Amphotericin B. [PDF]

, 2018
Disfiguring skin lesions caused by several species of the Leishmania parasite characterize cutaneous leishmaniasis (CL). Successful treatment of CL with intravenous (i.v.) liposomal amphotericin B (LAmB) relies on the presence of adequate antibiotic ...
Alavijeh, Mo, Croft, Simon L, Fortes Francisco, Amanda, Harris, Andy, Murdan, Sudaxshina, Van Bocxlaer, Katrien, Wijnant, Gert-Jan, Yardley, Vanessa   +7 more
core   +2 more sources