Conformational adaptation of Asian macaque TRIMCyp directs lineage specific antiviral activity [PDF]
, 2010 TRIMCyps are anti-retroviral proteins that have arisen independently in New World and Old World primates. All TRIMCyps comprise a CypA domain fused to the tripartite domains of TRIM5α but they have distinct lentiviral specificities, conferring HIV-1 ...
A Katzourakis +62 more
core +5 more sources
HeliyonLentiviruses, with their high transduction efficiency and gene expression levels, are widely used as gene delivery vectors in the development of chimeric antigen receptor T cells (CAR-T) and other genetically modified cell therapies.
Xueling Wu +7 more
doaj +1 more source
Skeletal Muscle, 2017 Background shRNA lentiviral vectors are extensively used for gene knockdowns in mammalian cells, and non-target shRNAs typically are considered the proper experimental control for general changes caused by RNAi.
Yutong Liu, Irina Conboy
doaj +1 more source
Overexpression of microRNA-16 declines cellular growth, proliferation and induces apoptosis in human breast cancer cells [PDF]
, 2015 MicroRNAs (miRNA) are a large family of small single-stranded RNA molecules found in all multicellular organisms. Early studies have been shown that miRNA are involved in cancer development and progression, and this role can be done by working as an ...
Hafizi, M. +8 more
core +2 more sources
Transduction of modified factor VIII gene improves lentiviral gene therapy efficacy for hemophilia A
, 2021 Jie Gong +4 more
openalex +1 more source
Improved Lentiviral Gene Delivery to Mouse Liver by Hydrodynamic Vector Injection through Tail Vein
Molecular Therapy: Nucleic Acids, 2018 Delivery of genes to mouse liver is routinely accomplished by tail-vein injections of viral vectors or naked plasmid DNA. While viral vectors are typically injected in a low-pressure and -volume fashion, uptake of naked plasmid DNA to hepatocytes is ...
Trine Dalsgaard +10 more
doaj +1 more source
Gene transfer to hepatocellular carcinoma: Transduction efficacy and transgene expression kinetics by using retroviral and lentiviral vectors [PDF]
, 2000 René Gerolami +6 more
openalex +1 more source
Lentiviral transduction of CD34(+) cells induces genome-wide epigenetic modifications.
PLoS ONE, 2012 Epigenetic modifications may occur during in vitro manipulations of stem cells but these effects have remained unexplored in the context of cell and gene therapy protocols.
Yoshiaki Yamagata +10 more
doaj +1 more source
Tal1/Scl Gene Transduction Using a Lentiviral Vector Stimulates Highly Efficient Hematopoietic Cell Differentiation from Common Marmoset ( Callithrix jacchus ) Embryonic Stem Cells [PDF]
, 2006 Ryo Kurita +14 more
openalex +1 more source
715. Lentiviral Transduction of MPS1 Bone Marrow Cells Results in High Production of alpha-L-Iduronidase In Vivo [PDF]
, 2011 openalex +1 more source