Slik and the receptor tyrosine kinase Breathless mediate localized activation of Moesin in terminal tracheal cells. [PDF]
PLoS ONE, 2014 A key element in the regulation of subcellular branching and tube morphogenesis of the Drosophila tracheal system is the organization of the actin cytoskeleton by the ERM protein Moesin.
Fiona Paul Ukken +3 more
doaj +1 more source
Human Pathology Reports, 2022 Context: Breast cancer is the most common cancer and the most common cause of death from cancer among women. Leptin is thought to play role in cell proliferation.
Irem Atalay Karacay +5 more
doaj +1 more source
The immunohistochemical expression of leptin in lymph node metastasis from laryngeal squamous cell carcinoma (SCC) [PDF]
, 2020 Introduction: Leptin is a proteohormone produced predominantly by white adipocytes and primarily known for its key role in the control of food intake and sense of satiety.
D'Alessi S +7 more
core +1 more source
Concordance of bioactive vs. total immunoreactive serum leptin levels in children with severe early onset obesity. [PDF]
PLoS ONE, 2017 Leptin secreted from adipose tissue signals peripheral energy status to the brain. Monogenic leptin deficiency results in severe early onset obesity with hyperphagia.
Juraj Stanik +8 more
doaj +1 more source
Biomolecules, 2023 Craniopharyngioma (CP) is a benign tumor with a high rate of obesity and frequent recurrence. Moreover, the role of leptin/leptin receptors axis in obesity and the prognosis of CP is still unknown.
Youchao Xiao +9 more
doaj +1 more source
BMC Genomics, 2014 A LEP transcript up-regulated in lungs of ducks (Anas platyrhynchos) infected by avian influenza A virus was recently described in the Nature Genetics manuscript that reported the duck genome. In vertebrates, LEP gene symbol is reserved for leptin, the key regulator of energy balance in mammals.Launching an extensive search for this gene in the genome ...
Friedman-Einat, Miriam, Seroussi, Eyal
openaire +2 more sources
Normal leptin expression, lower adipogenic ability, decreased leptin receptor and hyposensitivity to Leptin in Adolescent Idiopathic Scoliosis. [PDF]
PLoS ONE, 2012 Leptin has been suggested to play a role in the etiology of Adolescent Idiopathic Scoliosis (AIS), however, the leptin levels in AIS girls are still a discrepancy, and no in vitro study of leptin in AIS is reported.
Guoyan Liang +8 more
doaj +1 more source
Glucose enhances leptin signaling through modulation of AMPK activity. [PDF]
PLoS ONE, 2012 Leptin exerts its action by binding to and activating the long form of leptin receptors (LEPRb). LEPRb activates JAK2 that subsequently phosphorylates and activates STAT3.
Haoran Su +3 more
doaj +1 more source
In vivo and ex vivo regulation of visfatin production by leptin in human and murine adipose tissue : role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling pathways [PDF]
, 2009 Visfatin is an adipogenic adipokine with increased levels in obesity, properties common to leptin. Thus, leptin may modulate visfatin production in adipose tissue (AT).
Bee K. Tan +34 more
core +2 more sources
Molecular Metabolism, 2014 Objective: Leptin responsive neurons play an important role in energy homeostasis, controlling specific autonomic, behavioral, and neuroendocrine functions.
Kavon Rezai-Zadeh +8 more
doaj +1 more source