Results 11 to 20 of about 92,898 (97)
Leptin signaling and leptin resistance
Medical Review, 2022 Abstract With the prevalence of obesity and associated comorbidities, studies aimed at revealing mechanisms that regulate energy homeostasis have gained increasing interest. In 1994, the cloning of leptin was a milestone in metabolic research. As an adipocytokine, leptin governs food intake and energy homeostasis through leptin receptors
Jiarui Liu +3 more
openaire +3 more sources
Nutrients, 2020 Leptin is a hormone released by adipose tissue that plays a key role in the control of energy homeostasis through its binding to leptin receptors (LepR), mainly expressed in the hypothalamus. Most scientific evidence points to leptin’s satiating effect being due to its dual capacity to promote the expression of anorexigenic neuropeptides and to reduce ...
Patricia Seoane-Collazo +3 more
openaire +4 more sources
The Journal of Immunology, 2005 AbstractLeptin is an adipokine which conveys information on energy availability. In humans, leptin influences energy homeostasis and regulates neuroendocrine function primarily in states of energy deficiency. As a cytokine, leptin also affects thymic homeostasis and, similar to other proinflammatory cytokines, leptin promotes Th1 cell differentiation ...
MATARESE, GIUSEPPE +2 more
openaire +7 more sources
Current Immunology Reviews, 2008 The past few years of research on leptin have provided important information on the link between metabolism and immune homeostasis. Adipocytes influence not only the endocrine system but also the immune response through several cytokine-like mediators known as adipokines, which include leptin.
Iikuni N +4 more
openaire +6 more sources
Leptin signaling and leptin resistance [PDF]
Frontiers of Medicine, 2013 Leptin is secreted into the bloodstream by adipocytes and is required for the maintenance of energy homeostasis and body weight. Leptin deficiency or genetic defects in the components of the leptin signaling pathways cause obesity. Leptin controls energy balance and body weight mainly through leptin receptor b (LEPRb)-expressing neurons in the brain ...
Liangyou Rui, Yingjiang Zhou
openaire +3 more sources
Annual Review of Physiology, 2000 ▪ Abstract The discovery of the adipose-derived hormone leptin has generated enormous interest in the interaction between peripheral signals and brain targets involved in the regulation of feeding and energy balance. Plasma leptin levels correlate with fat stores and respond to changes in energy balance. It was initially proposed that leptin serves a
R S, Ahima, J S, Flier
openaire +5 more sources
BMC Genomics, 2014 A LEP transcript up-regulated in lungs of ducks (Anas platyrhynchos) infected by avian influenza A virus was recently described in the Nature Genetics manuscript that reported the duck genome. In vertebrates, LEP gene symbol is reserved for leptin, the key regulator of energy balance in mammals.Launching an extensive search for this gene in the genome ...
Miriam Friedman-Einat, Eyal Seroussi
openaire +3 more sources
Physiology International, 2021 AbstractAn imbalance between calorie intake and energy expenditure produces obesity. It has been a major problem in societies of the developing and developed world. In obesity an excessive amount of fat accumulates in adipose tissue cells as well as in other vital organs like liver, muscles, and pancreas.
M. Seth +4 more
openaire +4 more sources
Plasma leptin levels in pigs with different leptin and leptin receptor genotypes [PDF]
Journal of Animal Breeding and Genetics, 2008 SummaryA C3469T mutation at exon 3 of the pig leptin (Lep) gene has been genotyped in diverse pig breeds yielding controversial results with regard to its association with growth, fatness and carcass traits. A similar situation has been reported for a HpaII restriction fragment length polymorphism (RFLP) in the pig leptin receptor (Lepr) gene, where ...
Amills, Marcel +9 more
openaire +3 more sources
European Journal of Medical Research, 2010 Leptin or obesity receptor (Ob-R) is a member of class I cytokine receptor family. Ob-R, expressed in six isoforms, is the product of alternative RNA splicing of db gene. According to its structural differences, the receptor's isoforms are divided into three classes: long, short, and secretory isoforms.
Anna Stelmaszczyk-Emmel +5 more
openaire +3 more sources