Results 21 to 30 of about 134,905 (296)

The Neuronal Actions of Leptin and the Implications for Treating Alzheimer’s Disease

Pharmaceuticals, 2021
It is widely accepted that the endocrine hormone leptin controls food intake and energy homeostasis via activation of leptin receptors expressed on hypothalamic arcuate neurons.
Kirsty Hamilton, Jenni Harvey
doaj   +1 more source

Leptin and obesity [PDF]

Physiology International, 2021
AbstractAn imbalance between calorie intake and energy expenditure produces obesity. It has been a major problem in societies of the developing and developed world. In obesity an excessive amount of fat accumulates in adipose tissue cells as well as in other vital organs like liver, muscles, and pancreas.
M. Seth, R. Biswas, S. Ganguly, N. Chakrabarti, A.G. Chaudhuri   +4 more
openaire   +4 more sources

STAT3 phosphorylation in central leptin resistance

Nutrition & Metabolism, 2021
Mechanism exploitation of energy homeostasis is urgently required because of the worldwide prevailing of obesity-related metabolic disorders in human being.
Huimin Liu, Tianxin Du, Chen Li, Guoqing Yang   +3 more
doaj   +1 more source

Plasma leptin levels in pigs with different leptin and leptin receptor genotypes [PDF]

Journal of Animal Breeding and Genetics, 2008
SummaryA C3469T mutation at exon 3 of the pig leptin (Lep) gene has been genotyped in diverse pig breeds yielding controversial results with regard to its association with growth, fatness and carcass traits. A similar situation has been reported for a HpaII restriction fragment length polymorphism (RFLP) in the pig leptin receptor (Lepr) gene, where ...
Amills, Marcel, Villalba, D., Tor, M., Mercadé, Anna, Gallardo, David, Cabrera, Betlem, Jiménez, N., Noguera, José L., Sánchez, Armand, Estany, J.   +9 more
openaire   +3 more sources

Aberrant miR-874-3p/leptin/EGFR/c-Myc signaling contributes to nasopharyngeal carcinoma pathogenesis

Journal of Experimental & Clinical Cancer Research, 2022
Background Leptin is important in physiological and pathological functions in various cancers, however, the significance and mechanisms of leptin in nasopharyngeal carcinoma remain ambiguous.
Sheng-Dean Luo, Hsin-Ting Tsai, Chung-Feng Hwang, Tai‐Jan Chiu, Shau‐Hsuan Li, Ya-Ling Hsu, Chang-Chun Hsiao, Chang-Han Chen   +7 more
doaj   +1 more source

A theory that predicts behaviors of disordered cytoskeletal networks

Molecular Systems Biology, 2017
Morphogenesis in animal tissues is largely driven by actomyosin networks, through tensions generated by an active contractile process. Although the network components and their properties are known, and networks can be reconstituted in vitro, the ...
Julio M Belmonte, Maria Leptin, François Nédélec   +2 more
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Leptin and leptin receptor expression in asthma [PDF]

Journal of Allergy and Clinical Immunology, 2009
The adipokine leptin is a potential new mediator for bronchial epithelial homeostasis. Asthma is a chronic inflammatory disease characterized by airway remodeling that might affect disease chronicity and severity. TGF-beta is a tissue growth factor the dysregulation of which is associated with airway remodeling.We sought to determine whether a ...
Andreina Bruno, Mirella Profita, Isabelle Vachier, Giuseppina Chiappara, Mark Gjomarkaj, Stefania Gerbino, Pascal Chanez, Delphine Gras, Maurizio La Guardia, Elisabetta Pace   +9 more
openaire   +3 more sources

Leptin and Pro-Inflammatory Stimuli Synergistically Upregulate MMP-1 and MMP-3 Secretion in Human Gingival Fibroblasts. [PDF]

PLoS ONE, 2016
Gingival fibroblast-mediated extracellular matrix remodelling is implicated in the pathogenesis of periodontitis, yet the stimuli that regulate this response are not fully understood.
Rachel C Williams, Andrew J Skelton, Stephen M Todryk, Andrew D Rowan, Philip M Preshaw, John J Taylor   +5 more
doaj   +1 more source

Leptin revisited: The role of leptin in starvation [PDF]

Molecular & Cellular Oncology, 2018
Starvation causes reductions in plasma leptin concentrations, but the physiologic impact of this observation had not been documented in the starved state. Here we discuss our recent work demonstrating that hypoleptinemia activates the hypothalamic-pituitary-adrenal (HPA) axis, increasing white adipose tissue (WAT) lipolysis and mediating a shift from ...
openaire   +3 more sources

Leptin and puberty [PDF]

Archives of Disease in Childhood, 2000
Our knowledge of the potential genetic link between fat metabolism and the reproductive axis dates back to the 1950s when the obese ( ob/ob ) mouse strain was first described. These mice were not only distinctly hyperphagic and rapidly developed obesity associated with hyperglycaemia and insulin resistance, but they were also infertile.1 It was not ...
Clayton, PE, Trueman, JA.
openaire   +4 more sources