Results 21 to 30 of about 92,898 (97)
Leptin and leptin receptor expression in asthma [PDF]
Journal of Allergy and Clinical Immunology, 2009 The adipokine leptin is a potential new mediator for bronchial epithelial homeostasis. Asthma is a chronic inflammatory disease characterized by airway remodeling that might affect disease chronicity and severity. TGF-beta is a tissue growth factor the dysregulation of which is associated with airway remodeling.We sought to determine whether a ...
Andreina Bruno +9 more
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Leptin revisited: The role of leptin in starvation [PDF]
Molecular & Cellular Oncology, 2018 Starvation causes reductions in plasma leptin concentrations, but the physiologic impact of this observation had not been documented in the starved state. Here we discuss our recent work demonstrating that hypoleptinemia activates the hypothalamic-pituitary-adrenal (HPA) axis, increasing white adipose tissue (WAT) lipolysis and mediating a shift from ...
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Archives of Disease in Childhood, 2000 Our knowledge of the potential genetic link between fat metabolism and the reproductive axis dates back to the 1950s when the obese ( ob/ob ) mouse strain was first described. These mice were not only distinctly hyperphagic and rapidly developed obesity associated with hyperglycaemia and insulin resistance, but they were also infertile.1 It was not ...
Clayton, PE, Trueman, JA.
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Role of leptin and leptin receptor in inflammation
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2003 on october 30th, 2002, the World Health Report by the World Health Organization was launched subtitled Reducing risks, promoting healthy life . Many of the health risks discussed in this report concern food consumption—either too little, in the case of the poor, or too much, in the case of ...
Halle, Martin, Persson, P. B.
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Clinical Endocrinology, 2002 Leptin is a 167 amino acid hormonal protein product of the obesity gene that has been widely studied since its discovery by Zang et al . (1994). Initially described as being involved with satiety and energy balance, leptin was proposed to be the anti-obesity factor involved in a feedback loop from the adipocyte to the hypothalamus (Zang et al ., 1994).
Laurence M. Demers +3 more
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The role of leptin in leptin resistance and obesity
Physiology & Behavior, 2006 Although the presence of hyperleptinemia with leptin resistance and obesity has long been recognized, a causal role of elevated leptin in these biological states remains unclear. This article summarizes some recent work from our laboratory supporting the concept that leptin, in and of itself, promotes leptin resistance and such resistance compounds the
Research Service, Department of Veterans Affairs Medical Center, Gainesville, FL 32608, United States ( host institution ) +2 more
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Acute leptin deficiency, leptin resistance, and the physiologic response to leptin withdrawal [PDF]
Proceedings of the National Academy of Sciences, 2005 Food restriction and weight loss result in reduced plasma leptin, which is associated with a pleiotropic biologic response. However, because weight loss itself is also associated with changes in numerous other humoral and metabolic signals, it can be difficult to determine the precise features of the biologic response to acute leptin deficiency.
Gulnorakhon Fayzikhodjaeva +5 more
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Leptin: Is It Thermogenic? [PDF]
Endocrine Reviews, 2019 Abstract Animals that lack the hormone leptin become grossly obese, purportedly for 2 reasons: increased food intake and decreased energy expenditure (thermogenesis). This review examines the experimental evidence for the thermogenesis component. Analysis of the data available led us to conclude that the reports indicating hypometabolism
Alexander W. Fischer +3 more
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Kinetics of Leptin Binding to the Q223R Leptin Receptor
PLoS ONE, 2014 Studies in human populations and mouse models of disease have linked the common leptin receptor Q223R mutation to obesity, multiple forms of cancer, adverse drug reactions, and susceptibility to enteric and respiratory infections. Contradictory results cast doubt on the phenotypic consequences of this variant.
Verkerke, Hans +5 more
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Proceedings of the Nutrition Society, 1998 Fertility in mammals requires adequate nutrition and a certain reserve of metabolic fuel (Van Der Spuy, 1985). Individuals experiencing wasting diseases (e.g. insu- lin-dependent diabetes), severe dietary restriction (e.g. anorexics), or who are high-performance athletes (e.g.
Julian G. Mercer +4 more
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