Results 31 to 40 of about 134,905 (296)

Tetraploid genes of leptin (leptin-AI, -AII, -BI and -BII) in goldfish: Molecular cloning, bioinformatics analysis, tissue distribution and differential regulation of transcript expression by glucocorticoids

Aquaculture Reports, 2022
In mammals, leptin is an endocrine hormone involved in the regulation of feeding and energy metabolism, and glucocorticoids were previously reported to induce leptin gene expression.
Aifen Yan, Jiaxi Li, Lian Liu, Xiangxing Zhu, Chunhua Ren, Chaoqun Hu, Dongsheng Tang, Ting Chen   +7 more
doaj  

Establishment of Leptin-Responsive Cell Lines from Adult Mouse Hypothalamus. [PDF]

PLoS ONE, 2016
Leptin resistance is considered to be the primary cause of obesity. However, the cause of leptin resistance remains incompletely understood, and there is currently no cure for the leptin-resistant state.
Hiroshi Iwakura, Katsuko Dote, Mika Bando, Hiroyuki Koyama, Kiminori Hosoda, Kenji Kangawa, Kazuwa Nakao   +6 more
doaj   +1 more source

Role of leptin and leptin receptor in inflammation

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2003
on october 30th, 2002, the World Health Report by the World Health Organization was launched subtitled Reducing risks, promoting healthy life . Many of the health risks discussed in this report concern food consumption—either too little, in the case of the poor, or too much, in the case of ...
Halle, Martin, Persson, P. B.
openaire   +4 more sources

Dexamethasone and Acetate Modulate Cytoplasmic Leptin in Bovine Preadipocytes [PDF]

Asian-Australasian Journal of Animal Sciences, 2014
Hormonal and nutrient signals regulate leptin synthesis and secretion. In rodents, leptin is stored in cytosolic pools of adipocytes. However, not much information is available regarding the regulation of intracellular leptin in ruminants.
Shinichi Yonekura, Shohei Hirota, Yukako Tokutake, Michael T. Rose, Kazuo Katoh, Hisashi Aso   +5 more
doaj   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

The Effects of Laparoscopic Sleeve Gastrectomy on the Parameters of Leptin Resistance in Obesity

Biomolecules, 2019
Obesity is a growing public health problem worldwide. Bariatric surgical procedures achieve the most sustainable and efficacious outcomes in the treatment of morbid obesity.
Tagleb S. Mazahreh, Mahmoud Alfaqih, Rami Saadeh, Nabil A. Al-Zoubi, Moad Hatamleh, Ahmad Alqudah, Abdelwahab J. Aleshawi, Abdallah Alzoubi   +7 more
doaj   +1 more source

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source

Photoperiod-Induced Increases in Bone Mineral Apposition Rate in Siberian Hamsters and the Involvement of Seasonal Leptin Changes

Frontiers in Endocrinology, 2017
The adipokine leptin regulates energy balance, appetite, and reproductive maturation. Leptin also acts on bone growth and remodeling, but both osteogenic and anti-osteogenic effects have been reported depending on experimental conditions.
Marie Kokolski, Francis J. Ebling, James R. Henstock, Susan I. Anderson   +3 more
doaj   +1 more source

Leptin and the skeleton [PDF]

Clinical Endocrinology, 2002
Leptin is a 167 amino acid hormonal protein product of the obesity gene that has been widely studied since its discovery by Zang et al . (1994). Initially described as being involved with satiety and energy balance, leptin was proposed to be the anti-obesity factor involved in a feedback loop from the adipocyte to the hypothalamus (Zang et al ., 1994).
Laurence M. Demers, Tom Whipple, Neil A. Sharkey, Nancy I. Williams   +3 more
openaire   +3 more sources

Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness

Hepatology, EarlyView., 2022
Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran, Charlotte Wilhelmina Wernberg, Mette Munk Lauridsen, Maria Kløjgaard Skytthe, Sofie Marchsteiner Bendixen, Frederik Tibert Larsen, Camilla Dalby Hansen, Lea Ladegaard Grønkjær, Majken Storm Siersbæk, Tina Di Caterino, Sönke Detlefsen, Holger Jon Møller, Lars Grøntved, Kim Ravnskjaer, Søren Kragh Moestrup, Maja Sofie Thiele, Aleksander Krag, Jonas Heilskov Graversen   +17 more
wiley   +1 more source