Results 61 to 70 of about 134,905 (296)
Cellular Physiology and Biochemistry, 2017 Background/Aims: Leptin is a hormone expressed by adipose tissue that regulates body energy homeostasis and weight loss by activating leptin receptors in the hypothalamus. Leptin receptors are also expressed in astrocytes.
Hyunju Park +4 more
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Dementia and Geriatric Cognitive Disorders, 2012 Leptin has been reported to have positive effects on cognition but has not been studied in a population-based sample or stratified by race or gender.Leptin and fat mass were measured in 2,731 subjects, including 50% African Americans. Eight years later, subjects were administered the Montreal Cognitive Assessment (MoCA).
Linda S. Hynan +2 more
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Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine
Advanced Science, EarlyView.Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang +4 more
wiley +1 more source
Leptin: Is It Thermogenic? [PDF]
Endocrine Reviews, 2019 Abstract Animals that lack the hormone leptin become grossly obese, purportedly for 2 reasons: increased food intake and decreased energy expenditure (thermogenesis). This review examines the experimental evidence for the thermogenesis component. Analysis of the data available led us to conclude that the reports indicating hypometabolism
Alexander W. Fischer +3 more
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Emerging Nanotechnology Strategies for Obesity Therapy
Advanced Science, EarlyView.Three types of nanomaterials used for obesity treatment are highlighted, including inorganic nanomaterials, organic nanomaterials and biomimetic nanomaterials. A detailed and comprehensive introduction to the recent nanotechnology strategies for obesity management is also provided, including drug delivery, photodynamic therapy, hyperthermia, gas ...
Weili Chang +5 more
wiley +1 more source
LEPTIN RESISTANCE AND TYPE 2 DIABETES
International Journal of Medicine and Medical Research, 2017 Leptin is one of adipocyte-secreted hormones. It signals to the brain and other tissues about the status of body energy reserves. Circulating leptin levels are directly proportional to the amount of the body fat.
O. M. Oleshchuk, H. Ya. Loi
doaj +1 more source
Hyperleptinemia is required for the development of leptin resistance. [PDF]
PLoS ONE, 2010 Leptin regulates body weight by signaling to the brain the availability of energy stored as fat. This negative feedback loop becomes disrupted in most obese individuals, resulting in a state known as leptin resistance.
Zachary A Knight +3 more
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Proceedings of the Nutrition Society, 1998 Fertility in mammals requires adequate nutrition and a certain reserve of metabolic fuel (Van Der Spuy, 1985). Individuals experiencing wasting diseases (e.g. insu- lin-dependent diabetes), severe dietary restriction (e.g. anorexics), or who are high-performance athletes (e.g.
Julian G. Mercer +4 more
openaire +3 more sources
Advanced Science, EarlyView.Epidemiological data confirm obesity elevates thoracic aortic dissection (TAD) risk. Patient analyses implicate hyperleptinemia, where leptin binding to vascular smooth muscle cell (VSMC) receptors triggers Socs3‐mediated suppression of Stat5a transcriptional activity.
Ling Chen +18 more
wiley +1 more source
Folia Histochemica et Cytobiologica, 2008 Leptin and its receptor may be engaged in pathogenesis of breast cancer among various human tumors. In vitro investigations showed leptin-mediated escalation of estrogen synthesis and boosted activity of estrogen receptor ERalpha.
Stanislaw Sulkowski +4 more
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