Results 61 to 70 of about 239,997 (210)

Animal models of NASH: getting both pathology and metabolic context right [PDF]

, 2015
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of referral to liver clinics, and its progressive form, non-alcoholic steatohepatitis (NASH), can lead to cirrhosis and end-stage liver disease.
Larter, Claire Z., Yeh, Matthew M.
core   +1 more source

3D Bioprinted Fat‐Myocardium Model Unravels the Role of Adipocyte Hypertrophy in Atrial Dysfunction

Advanced Science, EarlyView.
A human‐derived 3D bioprinted fat–myocardium model is developed to investigate how adipocyte hypertrophy drives atrial dysfunction in obesity. Palmitate‐induced adipocyte hypertrophy promotes adipose dysfunction that impairs atrial cardiomyocyte metabolism and electrophysiology through both paracrine and direct interactions. This platform recapitulates
Lara Ece Celebi, Pinar Zorlutuna
wiley   +1 more source

The Potential Role of Leptin in the Regulation of Maternal Weight during Pregnancy and Its Impact on Neonate Weight and Apgar

Obesities
Leptin is secreted by adipose tissue and expressed in several organs, including the placenta. We investigated the influence of leptin in maternal blood on leptin expression and concentration in the placenta and umbilical cord and its influence on fetal ...
Daniela G. M. Fonseca, Maria-Carmen N. Souza-Carmo, Raquel N. Ruas, Solange S. Pereira, Lílian Goncalves Teixeira, e Jacqueline I. Alvarez-Leite   +5 more
doaj   +1 more source

Neuromedin U partially mediates leptin-induced hypothalamo-pituitary adrenal (HPA) stimulation and has a physiological role in the regulation of the HPA axis in the rat.

, 2006
Intracerebroventricular (ICV) administration of the hypothalamic neuropeptide neuromedin U (NMU) or the adipostat hormone leptin increases plasma ACTH and corticosterone.
Abbott, CR, Bloom, SR, Darch, SJ, Ghatei, MA, Jethwa, PH, Murphy, KG, Patel, SR, Semjonous, NM, Seth, A, Small, CJ, Smith, KL, Todd, JF   +11 more
core   +1 more source

Signalling Pathways Implicated in Obesity Associated Cancers [PDF]

, 2014
Grant support: The Scottish Government's Rural and Environment Science and Analytical Services Division. Declaration of interest: The author declares that there is no conflict of interest.Peer reviewedPublisher ...
Drew, Janice E.
core   +1 more source

Decreased leptin levels in antisocial personality disorder patients

Psychiatry and Clinical Psychopharmacology, 2021
Background: Leptin has attracted considerable interest in psychiatric disorders. It is expressed in the brain and an interaction between leptinergic and serotonergic systems has been demonstrated.
Recep Tutuncu, Huseyin Gunay, Hakan Balibey, Dilek Abaslı   +3 more
doaj   +1 more source

Fatty acid nitroalkenes ameliorate glucose intolerance and pulmonary hypertension in high-fat diet-induced obesity [PDF]

, 2014
Aims Obesity is a risk factor for diabetes and cardiovascular diseases, with the incidence of these disorders becoming epidemic. Pathogenic responses to obesity have been ascribed to adipose tissue (AT) dysfunction that promotes bioactive mediator ...
Baust, Jeff, Bonacci, Gustavo Roberto, Cantu Medellin, Nadiezhda, Champion, Hunter C., Croix, Claudette M. St., Devlin, Jason E., Freeman, Bruce A., Frisbee,Jefferson C., Gladwin, Mark T., Golin Bisello, Franca, Gor, Sonia, Kelley, Eric E., Khoo, Nicholas K.H., Watkins, Simon C., Weidert, Eric R.   +14 more
core   +1 more source

Expression of leptin and its receptor in female breast cancer in relation with selected apoptotic markers.

Folia Histochemica et Cytobiologica, 2008
Leptin and its receptor may be engaged in pathogenesis of breast cancer among various human tumors. In vitro investigations showed leptin-mediated escalation of estrogen synthesis and boosted activity of estrogen receptor ERalpha.
Stanislaw Sulkowski, Katarzyna Jarzabek, Luiza Kanczuga-Koda, Mariola Sulkowska, Mariusz Koda   +4 more
doaj   +3 more sources

Metabolic alterations in experimental models of depression [PDF]

, 2016
Introduction: Major depressive disorder is one of the most prevalent psychiatric disorders and is associated with a severe impact on the personal functioning, thus with incurring significant direct and indirect costs.
Ionescu, Ecaterina, Manea, Mihnea C, Manea, Mirela, Paraschiv, George L, Paunica, Ioana, Puiu, Maria G., Purnichi, Traian, Tache, Simona   +7 more
core   +4 more sources

Mouse circadian plasma leptin and active ghrelin rhythms under ad libitum and scheduled feeding [PDF]

, 2007
Thesis (M.S.) University of Alaska Fairbanks, 2007Light is the strongest timing cue for the circadian system, but non-photic cues can also entrain the master circadian clock, i.e., suprachiasmatic nuclei (SCN).
Wan, Haiting
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