Results 71 to 80 of about 239,997 (210)

Acute leptin deficiency, leptin resistance, and the physiologic response to leptin withdrawal [PDF]

Proceedings of the National Academy of Sciences, 2005
Food restriction and weight loss result in reduced plasma leptin, which is associated with a pleiotropic biologic response. However, because weight loss itself is also associated with changes in numerous other humoral and metabolic signals, it can be difficult to determine the precise features of the biologic response to acute leptin deficiency.
Jason M, Montez, Alex, Soukas, Esra, Asilmaz, Gulnorakhon, Fayzikhodjaeva, Giamila, Fantuzzi, Jeffrey M, Friedman   +5 more
openaire   +2 more sources

Leptin Suppresses Glutamate-Induced Apoptosis Through Regulation of ERK1/2 Signaling Pathways in Rat Primary Astrocytes

Cellular Physiology and Biochemistry, 2017
Background/Aims: Leptin is a hormone expressed by adipose tissue that regulates body energy homeostasis and weight loss by activating leptin receptors in the hypothalamus. Leptin receptors are also expressed in astrocytes.
Hyunju Park, So-Hee Ahn, Yieun Jung, Joo Chun Yoon, Youn-Hee Choi   +4 more
doaj   +1 more source

Effect of short-term probiotic Enterococcus faecium SF68 dietary supplementation in overweight and obese cats without comorbidities [PDF]

, 2016
Obesity in cats is associated with metabolic abnormalities and increased susceptibility to diseases such as diabetes mellitus. Studies in mouse models and human beings have shown that probiotics can reduce food intake, promote weight loss and improve ...
Fascetti, A J, Kass, P H, Kathrani, A, Larsen, J A   +3 more
core   +1 more source

Leptin receptor signaling: pathways to leptin resistance

Frontiers in Bioscience, 2011
The identification of spontaneous mutations in the leptin- and leptin receptor (ObR)-encoding ob and db gene, respectively, opened up a new field in obesity research. Leptin, an adipocyte-derived hormone, mirrors the body's fat stores and thereby informs the brain about the body's energy status.
Joris, Wauman, Jan, Tavernier
openaire   +2 more sources

Discovery of the elusive leptin in birds: identification of several 'missing links' in the evolution of leptin and its receptor. [PDF]

PLoS ONE, 2014
Leptin is a pleiotropic protein best known for regulation of appetite and fat storage in mammals. While many leptin orthologs have been identified among vertebrates, an authentic leptin in birds has remained elusive and controversial.
Jeremy W Prokop, Cameron Schmidt, Donald Gasper, Robert J Duff, Amy Milsted, Takeshi Ohkubo, Hope C Ball, Matthew D Shawkey, Herman L Mays, Larry A Cogburn, Richard L Londraville   +10 more
doaj   +1 more source

The leptin system and its expression at different nutritional and pregnant stages in lined seahorse (Hippocampus erectus)

Biology Open, 2016
Leptin is an essential hormone for the regulation of energy metabolism and food intake in vertebrate animals. To better understand the physiological roles of leptin in nutrient regulation in paternal ovoviviparous fish (family Syngnathidae), the present ...
Huixian Zhang, Geng Qin, Yanhong Zhang, Shuisheng Li, Qiang Lin   +4 more
doaj   +1 more source

Hyperleptinemia is required for the development of leptin resistance. [PDF]

PLoS ONE, 2010
Leptin regulates body weight by signaling to the brain the availability of energy stored as fat. This negative feedback loop becomes disrupted in most obese individuals, resulting in a state known as leptin resistance.
Zachary A Knight, K Schot Hannan, Matthew L Greenberg, Jeffrey M Friedman   +3 more
doaj   +1 more source

Impact of single nucleotide polymorphisms in leptin, leptin receptor, growth hormone receptor, and diacylglycerol acyltransferase (DGAT1) gene loci on milk production, feed, and body energy traits of UK dairy cows [PDF]

, 2008
The impact of 9 single nucleotide polymorphisms (SNP) in the leptin (LEP), leptin receptor (LEPR), growth hormone receptor (GHR), and diacylglycerol acyltransferase (DGAT1) gene loci on daily milk production, feed intake, and feed conversion, and weekly ...
Banos, G., Coffey, M. P., Forbes, A. B., Woodward, B. W., Woolliams, J. A.   +4 more
core   +1 more source

Circulating leptin, soluble leptin receptor, free leptin index, visfatin and selected leptin and leptin receptor gene polymorphisms in sporadic breast cancer

Endocrine Journal, 2017
Leptin and visfatin are implicated in breast cancer risk but studies accounting for bioavailability of leptin are sparse. Reports on the association of leptin gene (LEP) and leptin receptor gene (LEPR) polymorphisms with breast cancer are also inconsistent.
Chrishani, Rodrigo, Kamani Hemamala, Tennekoon, Eric Hamilton, Karunanayake, Kanishka, De Silva, Indrani, Amarasinghe, Ananda, Wijayasiri   +5 more
openaire   +3 more sources

Inhibition of food intake in obese subjects by peptide YY3-36 [PDF]

, 2003
Background: The gut hormone fragment peptide YY3-36 (PYY) reduces appetite and food intake when infused into subjects of normal weight. In common with the adipocyte hormone leptin, PYY reduces food intake by modulating appetite circuits in the ...
Batterham, RL, Bloom, SR, Cohen, MA, Ellis, SM, Frost, GS, Ghatei, MA, Le Roux, CW, Withers, DJ   +7 more
core   +1 more source