Results 81 to 90 of about 239,997 (210)

Plasma leptin levels in pigs with different leptin and leptin receptor genotypes

Journal of Animal Breeding and Genetics, 2008
SummaryA C3469T mutation at exon 3 of the pig leptin (Lep) gene has been genotyped in diverse pig breeds yielding controversial results with regard to its association with growth, fatness and carcass traits. A similar situation has been reported for a HpaII restriction fragment length polymorphism (RFLP) in the pig leptin receptor (Lepr) gene, where ...
Amills, Marcel, Villalba, D., Tor, M., Mercadé, Anna, Gallardo, David, Cabrera, Betlem, Jiménez, N., Noguera, José L., Sánchez, Armand, Estany, J.   +9 more
openaire   +3 more sources

The glucoregulatory actions of leptin

Molecular Metabolism, 2017
Background: The hormone leptin is an important regulator of metabolic homeostasis, able to inhibit food intake and increase energy expenditure. Leptin can also independently lower blood glucose levels, particularly in hyperglycemic models of leptin or ...
Anna M. D'souza, Ursula H. Neumann, Maria M. Glavas, Timothy J. Kieffer   +3 more
doaj   +1 more source

Decreased leptin concentration in neonates is associated with enhanced postnatal growth during the first year

Kaohsiung Journal of Medical Sciences, 2012
Leptin regulates maternal metabolism and fetal growth by reducing food intake and increasing energy expenditure, particularly during the third trimester.
Ling-Jen Wang, Shu-Chi Mu, I Cheng, Yi-Ling Chen, Bing-Fang Chen, Guey-Mei Jow   +5 more
doaj   +1 more source

Anticontractile effect of perivascular adipose tissue and leptin are reduced in hypertension

Frontiers in Pharmacology, 2012
Leptin causes vasodilatation both by endothelium-dependent and -independent mechanisms. Leptin is synthetized by perivascular adipose tissue (PVAT). The hypothesis of this study is that a decrease of leptin production in PVAT of spontaneously rats (SHR ...
Beatriz eGálvez-Prieto, Beatriz eSomoza, Marta eGil-Ortega, Concha eF García-Prieto, Ana ede las Heras, María eGonzález, Silvia eArribas, Isabel eAranguez, Juliane eBolbrinker, Reinhold eKreutz, Mariano eRuiz-Gayo, María S Fernández-Alfonso   +11 more
doaj   +1 more source

Genomic and epigenomic mapping of leptin-responsive neuronal populations involved in body weight regulation. [PDF]

, 2019
Genome wide association studies (GWAS) in obesity have identified a large number of noncoding loci located near genes expressed in the central nervous system.
Ahituv, Nadav, Eckalbar, Walter L, Inoue, Fumitaka, Matharu, Navneet, Murphy, Karl K, Vaisse, Christian, Wang, Yi   +6 more
core   +1 more source

Leptin and leptin resistance in obesity: current evidence, mechanisms and future directions

Endocrine Connections
Leptin, a key adipokine regulating energy homeostasis, has been extensively studied for its potential in the management of obesity. However, its therapeutic efficacy is often limited due to leptin resistance.
Wenjing Hu, Huijuan Zhu, Fengying Gong
doaj   +1 more source

Transcriptional Regulation of Neuronal Genes and Its Effect on Neural Functions: Transcriptional Regulation of Neuropeptide Y Gene by Leptin and Its Effect on Feeding

Journal of Pharmacological Sciences, 2005
Leptin is an adipose tissue-derived secretory hormone that suppresses appetite by inhibition of neuropepeptide Y (NPY) gene expression in arcuate nucleus (ARC) in the hypothalamus.
Hiroshi Higuchi, Ayumi Hasegawa, Tsuyoshi Yamaguchi   +2 more
doaj   +1 more source

New mutations at the imprinted Gnas cluster show gene dosage effects of Gsα in postnatal growth and implicate XLαs in bone and fat metabolism, but not in suckling [PDF]

, 2012
The imprinted Gnas cluster is involved in obesity, energy metabolism, feeding behavior, and viability. Relative contribution of paternally expressed proteins XLαs, XLN1, and ALEX or a double dose of maternally expressed Gsα to phenotype has not been ...
Abramowitz J, Balthasar N, Bamshad M, Bartness TJ, Bastepe M, Bastepe M, Baxendale RW, Bunting M, Castrop H, Cattanach BM, Cattanach BM, Chen M, Chen M, Chen M, Chotalia M, Crawford JA, de Bovis B, de Paula FJ, Ducy P, Elefteriou F, Friedman JM, Fu L, Fukao M, Germain-Lee EL, Hayward BE, Holmes R, Ivanova E, Kawai M, Kaya AI, Kehlenbach RH, Kelly ML, Kelsey G, Klemke M, Klemke M, Kublaoui BM, Lam DD, Liu J, Maffei M, Moore T, Oswal A, Pasolli HA, Pasolli HA, Peters J, Peters J, Peters J, Plagge A, Plagge A, Sakamoto A, Sakamoto A, Schmidt-Nielsen K, Shin JY, Shrestha YB, Skinner JA, Sleutels F, Storck T, Weinstein LS, Weinstein LS, Williamson CM, Williamson CM, Williamson CM, Wroe SF, Xie T, Yadav VK, Youngstrom TG, Yu S, Yu S   +65 more
core   +1 more source

Leptin Promotes the Expression of Pro-inflammatory Mediator Genes but Does Not Alter Osteoclastogenesis and Early Stage Differentiation of Osteoblasts

Journal of Physiological Investigation
Leptin, a hormone secreted by adipose tissue, plays a pivotal role in maintaining energy metabolism and bone quality. Dysregulation of leptin can lead to the development of various pathological conditions.
Chien-Ning Hsu, Chih-Hong Kao, Chin-Hua Yang, Ming-Te Cheng, Yu-Pao Hsu, Shinn-Gwo Hong, Chao-Ling Yao, Yu-Hsu Chen   +7 more
doaj   +1 more source

Differential modulation of arcuate nucleus and mesolimbic gene expression levels by central leptin in rats on short-term high-fat high-sugar diet.

PLoS ONE, 2014
ObjectiveLeptin resistance is a common hallmark of obesity. Rats on a free-choice high-fat high-sugar (fcHFHS) diet are resistant to peripherally administered leptin. The aim of this study was to investigate feeding responses to central leptin as well as
José K van den Heuvel, Leslie Eggels, Eric Fliers, Andries Kalsbeek, Roger A H Adan, Susanne E la Fleur   +5 more
doaj   +1 more source