Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders
Andrology, EarlyView.Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret +5 more
wiley +1 more source
International Journal of Reproductive BioMedicine, 2018 Background: Leptin resistance is associated with lower reproductive efficiency, with deficiencies in embryo viability and growth leading to low prolificacy and high incidence of intrauterine growth restriction.
Pedro Gonzalez-Añover +7 more
doaj
Leptin resistance in children with in utero exposure to maternal obesity and gestational diabetes. [PDF]
Pediatr Obes, 2023 Everett AB +10 more
europepmc +1 more source
Influence of anthropometric parameters, leptin, adiponectin, and insulin resistance on blood pressure in obese women [PDF]
, 2015 Milena Velojić Golubović +4 more
openalex +1 more source
Protein tyrosine phosphatases as emerging targets for cancer immunotherapy
British Journal of Pharmacology, EarlyView.Abstract Contemporary strategies in cancer immunotherapy, despite remarkable success, remain constrained by inherent limitations such as suboptimal patient responses, the emergence of drug resistance, and the manifestation of pronounced adverse effects. Consequently, the need for alternative strategies for immunotherapy becomes clear.
Zihan Qu, Jiajun Dong, Zhong‐Yin Zhang
wiley +1 more source
Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?
British Journal of Pharmacology, EarlyView.Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli +7 more
wiley +1 more source
Assessment of follicular fluid leptin levels and insulin resistance as outcome predictors in women undergoing in vitro fertilization–intracytoplasmic sperm injection [PDF]
, 2014 David Llaneza-Suárez +7 more
openalex +1 more source
Cytochrome P450 1A1 influences obesity‐induced pulmonary hypertension
British Journal of Pharmacology, EarlyView.Background and Purpose The contribution of obesity to pulmonary arterial hypertension (PAH) pathophysiology remains poorly understood. Adipose tissue synthesises estrogens via cytochrome P450 (CYP) 19A1 (aromatase), whereas circulating estrogens are metabolised in the lung by CYP1A1.
Joshua P. Dignam +12 more
wiley +1 more source
Dynamics of Apolipoprotein J Levels and Metabolic Parameters Following Bariatric Surgery
Clinical Endocrinology, EarlyView.ABSTRACT Objective Bariatric surgery has emerged as a potent intervention for ameliorating insulin resistance and its associated comorbidities in obese patients. Apolipoprotein J (ApoJ) and adiponectin are closely associated with insulin resistance and sensitivity, respectively.
Kellen Cristina da Cruz Rodrigues +7 more
wiley +1 more source