Results 121 to 130 of about 80,968 (287)

Possible integrative actions of leptin and insulin signaling in the hypothalamus targeting energy homeostasis

Frontiers in Endocrinology, 2016
Obesity has emerged as one of the most burdensome conditions in modern society. In this context, understanding the mechanisms controlling food intake is critical.
Mina Thon, Toru Hosoi, Koichiro Ozawa
doaj   +1 more source

Mechanisms underlying leptininduced cardioprotection

, 2010
BACKGROUND: The tissue damage resulting from myocardial ischaemia/reperfusion (I/R) leads to a large proportion of the deaths in the developed world.
Dixon, R.A.
core  

The Role of Polyphenols in Respiratory and Gut Health: From the Perspective of Gut‐Lung Axis

Phytotherapy Research, EarlyView.
ABSTRACT The gut‐lung axis constitutes a dynamic, multidirectional communication platform between the gastrointestinal and respiratory tracts. Its complexity arises from the integrated crosstalk among the microbiota, immune system, and redox homeostasis, collectively influencing disease susceptibility and progression.
Jian Kang, YongJun Du, Yanmei Hou, Liangliang Hao, Zhen Chen, Haoyang Xie, Chuantao Zhang, Lei Li   +7 more
wiley   +1 more source

LEPTIN RESISTANCE AND TYPE 2 DIABETES

, 2017
Leptin is one of adipocyte-secreted hormones. It signals to the brain and other tissues about the status of body energy reserves. Circulating leptin levels are directly proportional to the amount of the body fat.
H. Ya. Loi, Oleshchuk, O. M., O. M. Oleshchuk, Loi, H. Ya.   +3 more
core   +1 more source

PFOA Exposure Elicits Quantitative Lipidomic Changes in the Pancreas in a Mouse Model of Pancreatic Cancer

Environmental Toxicology, EarlyView.
ABSTRACT Pancreatic cancer is the fourth leading cause of cancer deaths in the US and predicted to rise to second by 2030. Several risk factors have been identified as potential contributors to pancreatic cancer development including lifestyle factors and long‐term exposure to occupational and environmental carcinogens.
Barbara A. Hocevar, Lisa M. Kamendulis
wiley   +1 more source

Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance

, 2011
In obesity, anorectic responses to leptin are diminished, giving rise to the concept of “leptin resistance.” Increased expression of protein tyrosine phosphatase 1B (PTP1B) has been associated with the attenuation of leptin signaling and development of ...
Zhang, Zhong-Yin, Cowley, Michael A., Zhang, Zhong-Yi, Tiganis, Tony, Sandra Galic, Loh, Ki, Barbara B. Kahn, Florian Wiede, Galic, Sandra, Alexander Reichenbach, Christine Hauser, Sims, Natalie A, Pablo J. Enriori, Enriori, Pablo J, Stephanie Simonds, Zhong-Yin Zhang, Loh, Kim, Andrews, Zane B, Andrews, Zane B., Kim Loh, Simonds, Stephanie, Cowley, Michael A, Kahn, Barbara B., Tony Tiganis, Bence, Kendra K., Reichenbach, Alexander, Dana Briggs, Zhang, Sheng, Benjamin G. Neel, Hauser, Christine, Sheng Zhang, Michael A. Cowley, Neel, Benjamin G, Zhang, Xinmei, Enriori, Pablo J., Natalie A. Sims, Fukushima, Atsushi, Kahn, Barbara B, Neel, Benjamin G., Briggs, Dana, Zane B. Andrews, Xinmei Zhang, Wiede, Florian, Bence, Kendra K, Sims, Natalie A., Atsushi Fukushima, Kendra K. Bence   +46 more
core   +2 more sources

Microplastics and the Endocrine–Metabolic Interface: Novel Diagnostic Tools Targeting Thyroid–Adipose Axis

Environmental Toxicology, EarlyView.
ABSTRACT Microplastics (MPs) have been identified as major environmental contaminants that can affect organisms directly and act as carriers of particles and chemical additives, thereby aggravating endocrine networks that coordinate metabolic homeostasis.
Sunday Amos Onikanni, Babasola Aiyeku, Marjorie Dardis Murucci, Temitope Aribigbola, Kenia Bispo, Oluwatosin Stella Olayinka, Rômulo Sperduto Dezonne, Sara Gemini Piperni, Paula Soares, Denise Pires de Carvalho, Leandro Miranda‐Alves   +10 more
wiley   +1 more source

Periodontitis and metabolic diseases (diabetes and obesity): Tackling multimorbidity

Periodontology 2000, EarlyView., 2023
Abstract Noncommunicable diseases (NCDs) are multifactorial, long‐term, chronic conditions that represent a burden to health‐care systems worldwide as they can only be controlled rather than cured; hence, they require long‐term care. With the exponential increase in NCDs, the occurrence of individuals presenting with more than one chronic disease is ...
Crystal Marruganti, Jean E. Suvan, Francesco D'Aiuto   +2 more
wiley   +1 more source

Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats

, 2010
[[abstract]]This study examined the effect of intracerebroventricular leptin on insulin sensitivity in streptozotocin (STZ)-induced diabetic rats.
LIN CY; Higginbotham DA; Judd RL; White BD
core  

Elevated cord leptin from low B12 mothers predicts birth weight

, 2014
Vitamin B12 (B12) insufficiency is common in pregnancy and independently predicts insulin resistance (IR) in the offspring. B12 is an important key nutrient for epigenetic programming through regulating DNA methylation.
Wood, C, Saravanan, P, Sivakumar, K, Tripathi, G, Vatish, M, Webster, C, Anderson, N, Lawson, A, Antonysunil, A, McTernan, P   +9 more
core   +1 more source