Results 111 to 120 of about 80,968 (287)

Changes in endotoxin levels in T2DM subjects on anti-diabetic therapies [PDF]

, 2009
Introduction Chronic low-grade inflammation is a significant factor in the development of obesity associated diabetes. This is supported by recent studies suggesting endotoxin, derived from gut flora, may be key to the development of inflammation by ...
Al-Attas, Omar S, Kumar Sudhesh, Shaun L Sabico, da Silva, Nancy F., Sabico, Shaun, McTernan Philip G, Sudhesh Kumar, Omar S Al-Attas, Al-Attas, Omar S., Harte, A. L. (Alison L.), Philip G McTernan, Al-Daghri, Nasser M., Al-Attas Omar S, Al-Rubeaan, Khalid, Alison L Harte, Khalid Al-Rubeaan, Nancy F da Silva, Sabico Shaun L, Kumar, Sudhesh, Al-Rubeaan Khalid, Nasser M Al-Daghri, da Silva Nancy F, Harte Alison L, Al-Daghri Nasser M, McTernan, P. G. (Philip G.)   +24 more
core   +1 more source

Obesity as a Risk Factor for Alzheimer’s Disease: Implication of Leptin and Glutamate

Frontiers in Neuroscience, 2019
Obesity is known to induce leptin and insulin resistance. Leptin is a peptide hormone synthesized in adipose tissue that mainly regulates food intake.
Ana Lloret, Paloma Monllor, Daniel Esteve, Ana Cervera-Ferri, Maria-Angeles Lloret   +4 more
doaj   +1 more source

Leptin and peroxisome proliferator activated receptor alpha: understanding their contribution towards normalising the programmed phenotype in the peripheral tissues of IUGR offspring

, 2010
In a rat model of intrauterine growth restriction (IUGR) induced by maternal global undernutrition, adult offspring are obese with associated metabolic disturbances. These metabolic abnormalities are all augmented by feeding a high calorie postnatal diet
Garratt, Emma
core  

Monogenic and syndromic obesity in children: Clinical recognition, genetics, and precision management

Pediatric Investigation, EarlyView.
Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil, Eugene Feigin, Hussein Zaitoon   +2 more
wiley   +1 more source

Comparison of the effects of endurance, resistance and concurrent training on insulin resistance and adiponectin-leptin ratio in diabetic rat

The Journal of Qazvin University of Medical Sciences, 2017
Background: The obesity-related hormones leptin and adiponectin are independently and oppositely associated with insulin resistance. Objective: The aim of the present study was to investigate the effect of endurance, resistance and concurrent training ...
A. Saremi
doaj  

Metabolic syndrome, the leptin gene and kidney disease in non-diabetic black South Africans

, 2008
Includes abstract.Includes bibliographical references (leaves 226-256).Obesity is a worldwide problem and is a factor in the pathogenesis of the metabolic syndrome and kidney disease through the development of obesity-related hypertension and ...
Okpechi, Ikechi Gareth
core  

Circadian Dysfunction Induces Leptin Resistance in Mice [PDF]

, 2015
SummaryCircadian disruption is associated with obesity, implicating the central clock in body weight control. Our comprehensive screen of wild-type and three circadian mutant mouse models, with or without chronic jet lag, shows that distinct genetic and ...
Mayo, Sara A., Lee, Choogon, Moore, David D., Hua, Jack, Moore, David D, Kettner, Nicole M., Fu, Loning, Kettner, Nicole M, Mayo, Sara A   +8 more
core   +1 more source

Evidence map and gap analysis of metabolic change in pediatric growth hormone deficiency treated with growth hormone

Pediatric Investigation, EarlyView.
This evidence map of 63 studies (n = 6158) showed growth hormone therapy in children with growth hormone deficiency has neutral glucose effects, mixed lipid outcomes, potential benefits for bone mineral density, bone mineral content, and parathyroid hormone, but generally no impact on thyroid function, body composition, or body mass index.
Wei Wu, Ningyi Song, Yue Zhao, Caiqi Du, Yuning Zhao, You Wu, Xiaoping Luo   +6 more
wiley   +1 more source

Leptin induces altered differentiation of keratinocytes by inducing insulin resistance: implications for metabolic syndrome-induced resistance of psoriatic therapy

Journal of Dermatological Treatment
Background: Psoriatic patients tend to develop metabolic syndrome (MS). MS accelerates psoriasis, but the exact molecular mechanisms are poorly understood.Objectives: We aim to investigate the impact of leptin on keratinocyte insulin sensitivity and ...
Rui Wang, Chongli Yu, Zijie Tang, Jie Sun, Youlin Wang, Zhenkai Zhao, Biwen Lin, Chengxin Li   +7 more
doaj   +1 more source

When Fat Goes Astray: Your Liver and Pancreas Get Into Trouble

Portal Hypertension &Cirrhosis, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) and intrapancreatic fat deposition (IPFD) are both common manifestations of ectopic fat accumulation. Although they share multiple risk factors, they also show notable differences in pathological features, standardization of diagnosis, and research maturity.
Yuying Chen, Li Ding, Shan Zhao, Weihong Wang, Jing Zhong, Qiang Yan   +5 more
wiley   +1 more source