Results 131 to 140 of about 2,304,681 (286)
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley +1 more source
LEPTIN RESISTANCE AND TYPE 2 DIABETES [PDF]
, 2017 Leptin is one of adipocyte-secreted hormones. It signals to the brain and other tissues about the status of body energy reserves. Circulating leptin levels are directly proportional to the amount of the body fat.
H. Ya. Loi +3 more
core +1 more source
Metabolic Syndrome and Dementia Risk in Older Adults: A Narrative Review
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Dementia is a major global health issue in aging societies. Metabolic syndrome (MetS), a cluster of metabolic abnormalities, has been proposed as a modifiable risk factor for dementia, although existing evidence remains inconsistent. This review examined recent studies on the association between MetS and dementia risk in older adults.
Hyojin Park +2 more
wiley +1 more source
A molecular overview of leptin in several pathological conditions
, 2023 Leptin is a 16 kDa peptide hormone that is the product of LEP (also known as OB) gene. The Leptin gene is primarily expressed in white adipocytes. Although the leptin hormone is mainly associated with the regulation of body weight and energy expenditure ...
Ceylan,M.A., Gozel,H.E.
core
Molecular Carcinogenesis, EarlyView.ABSTRACT Herein, using the LSL‐KrasG12D/+; p48Cre/+ transgenic mouse model [that recapitulates the full spectrum of human disease, progressing from early pancreatic intraepithelial neoplasia lesions to invasive pancreatic ductal adenocarcinoma (PDAC)], we determined the chemopreventive effect of long‐term (chronic) administration of Bitter Melon Juice (
Lakshmi Sai Pratyusha Bugata +7 more
wiley +1 more source
Leptin resistance: unsolved diagnostic issues
, 2018 Leptin and its receptors are key regulators of body weight and energy homeostasis. A decrease in tissue sensitivity to leptin leads to the development of obesity, insulin resistance, dyslipidemia, etc.
Daria A. Borodkina +5 more
core +1 more source
Prevention of Early Onset of Breast Cancer With Ashwagandha
Molecular Carcinogenesis, EarlyView.ABSTRACT Prevention of breast cancer is feasible because many risk factors for this malignancy are known (e.g., family history, reproductive factors, etc.). Medicinal plants and/or their bioactive phytochemicals are attractive for the prevention of early onset of breast cancer due to their generally favorable safety profile.
Eun‐Ryeong Hahm +2 more
wiley +1 more source
The role of leptin in diabetes and its complications
, 2023 Leptin is an important adipokine that is implicated in regulating energy metabolism and appetite to control food intake. However, the serum level of leptin is influenced by various factors, such as diet, lifestyle, and health conditions.
Zhang, Cheng +4 more
core
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Protein Tyrosine Phosphatases (PTPs) regulate cellular signaling by balancing phosphotyrosine levels through a conserved WPD‐loop that switches between open (inactive) and closed (active) conformations. While this conformational change is crucial for catalysis, the structural factors governing this motion remain poorly understood.
Colin L. Welsh, Lalima K. Madan
wiley +1 more source
Characterization and remodeling of the vasculature in human adipose tissue [PDF]
, 2007 Die Ursache von Adipositas liegt im übermäßigen Wachstum von Fettgewebe, welches hauptsächlich aus Fettzellen, den Adipozyten, besteht. Die Zellen der stroma-vaskulären Fraktion, welche Vorläuferzellen, Makrophagen und Zellen des lokalen Gefäßnetzwerks ...
Miranville, Alexandra
core