Results 141 to 150 of about 80,968 (287)

Assessing a Model for a Complex Systemic Disorder—The Value of Male Mice With a Supernumerary X Chromosome for Klinefelter Syndrome Research

Andrology, EarlyView.
ABSTRACT Introduction Direct experimental investigation of Klinefelter syndrome (KS) in patients is limited because the syndrome manifests heterogeneously and affects multiple organ systems. Studying KS therefore requires a model that captures this complexity as accurately as possible while still permitting controlled experimental manipulation ...
Fariba Saadati, Joachim Wistuba
wiley   +1 more source

The Effects of a Single Session of Combined Aerobic and Resistance Exercise on Leptin Levels and Insulin Resistance Index in Sedentary Men [PDF]

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2012
Background and Objectives: Physical activity energy expenditure may mediate the relationship between plasma leptin levels and worsening insulin resistance independent of adiposity.
Azarbayejani M.A., Abedi B., Piri M., Rasaie M.J.   +3 more
doaj  

Leptin resistance in children with in utero exposure to maternal obesity and gestational diabetes. [PDF]

Pediatr Obes, 2023
Everett AB, Garvey WT, Fernandez JR, Habegger K, Harper LM, Battarbee AN, Martin SL, Moore BA, Fouts AE, Bahorski J, Chandler-Laney PC.   +10 more
europepmc   +1 more source

Prolactin in high‐metabolic risk pregnancies: Associations with maternal obesity and metabolic health

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Higher maternal BMI before and during early pregnancy is associated with lower prolactin levels across gestation and a reduced prolactin rise. Prolactin in pregnancy may reflect maternal metabolic health and has potential relevance to lactation outcomes.
Kate Rassie, Simon Alesi, Adriana C. H. Neven, Taitum Mason, Eveline Jona, Stacey J. Ellery, Joanne Enticott, Aya Mousa, Anju E. Joham, David Simmons, Helena Teede, on behalf of the TOBOGM Core Investigator Group   +11 more
wiley   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Characterization and remodeling of the vasculature in human adipose tissue

, 2007
Die Ursache von Adipositas liegt im übermäßigen Wachstum von Fettgewebe, welches hauptsächlich aus Fettzellen, den Adipozyten, besteht. Die Zellen der stroma-vaskulären Fraktion, welche Vorläuferzellen, Makrophagen und Zellen des lokalen Gefäßnetzwerks ...
Miranville, Alexandra
core  

Neurokinin‐1 receptor activation protects against cardiac fibrosis, inflammation and diastolic dysfunction in type 2 diabetic mice

British Journal of Pharmacology, EarlyView.
Background and Purpose The pathogenesis of type 2 diabetes mellitus (T2DM)‐induced cardiomyopathy involves cardiac fibrosis that leads to diastolic dysfunction. We established that replacement of lost substance P (SP) that occurs in T2DM reduces cardiac fibrosis and decreases inflammation in T2DM mice and non‐human primates.
Alexander Widiapradja, Heather Connery, Brody J. Helmick, Kallie J. Schafner, Vamsi Manchikalapudi, Hannah Horvath, Sophia Gugino, Tamas Kriska, Anja Herrnreiter, Evan DeVallance, William B. Campbell, Scott P. Levick   +11 more
wiley   +1 more source

Modulation of Leptin Resistance by Protein Tyrosine Phosphatases

, 2012
Leptin plays a central role in weight control by suppressing food intake and increasing energy expenditure. The concept of leptin resistance emerged to explain the seemingly paradoxical elevated leptin levels in obesity.
Tremblay, Michel L., St-Pierre, Julie
core   +1 more source

Leptin Resistance and Obesity

Endocrine Journal, 2007
SHIMIZU, Hiroyuki, OH-I, Shinsuke, OKADA, Shuichi, MORI, Masatomo   +3 more
openaire   +3 more sources

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

British Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source