Results 141 to 150 of about 134,529 (291)

Assessing a Model for a Complex Systemic Disorder—The Value of Male Mice With a Supernumerary X Chromosome for Klinefelter Syndrome Research

Andrology, EarlyView.
ABSTRACT Introduction Direct experimental investigation of Klinefelter syndrome (KS) in patients is limited because the syndrome manifests heterogeneously and affects multiple organ systems. Studying KS therefore requires a model that captures this complexity as accurately as possible while still permitting controlled experimental manipulation ...
Fariba Saadati, Joachim Wistuba
wiley   +1 more source

The Effects of a Single Session of Combined Aerobic and Resistance Exercise on Leptin Levels and Insulin Resistance Index in Sedentary Men [PDF]

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2012
Background and Objectives: Physical activity energy expenditure may mediate the relationship between plasma leptin levels and worsening insulin resistance independent of adiposity.
Azarbayejani M.A., Abedi B., Piri M., Rasaie M.J.   +3 more
doaj  

Fat reduction mediates the efficacy of intensive lifestyle interventions on fertility‐sparing treatment in overweight patients with endometrial cancer and intraepithelial neoplasia

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Intensive lifestyle interventions‐based weight management targeting fat reduction may enhance fertility‐sparing treatment outcomes in overweight patients with endometrial cancer or its precursor. Our findings advocate the integration of body composition‐guided weight management into standardized protocols.
Sijia Liu, Li Li, Pengfei Wu, Lulu Wang, Qujia Gama, Manrong Wang, Jinyu Zhang, Liping Jin, Xuezhen Luo, Weiwei Shan, Bingyi Yang   +10 more
wiley   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Leptin resistance in children with in utero exposure to maternal obesity and gestational diabetes. [PDF]

Pediatr Obes, 2023
Everett AB, Garvey WT, Fernandez JR, Habegger K, Harper LM, Battarbee AN, Martin SL, Moore BA, Fouts AE, Bahorski J, Chandler-Laney PC.   +10 more
europepmc   +1 more source

Neurokinin‐1 receptor activation protects against cardiac fibrosis, inflammation and diastolic dysfunction in type 2 diabetic mice

British Journal of Pharmacology, EarlyView.
Background and Purpose The pathogenesis of type 2 diabetes mellitus (T2DM)‐induced cardiomyopathy involves cardiac fibrosis that leads to diastolic dysfunction. We established that replacement of lost substance P (SP) that occurs in T2DM reduces cardiac fibrosis and decreases inflammation in T2DM mice and non‐human primates.
Alexander Widiapradja, Heather Connery, Brody J. Helmick, Kallie J. Schafner, Vamsi Manchikalapudi, Hannah Horvath, Sophia Gugino, Tamas Kriska, Anja Herrnreiter, Evan DeVallance, William B. Campbell, Scott P. Levick   +11 more
wiley   +1 more source

CRF1 and ACTH inhibitors are a promising approach to treat obesity and leptin and insulin resistance

Frontiers in Endocrinology
Evidence synthesisObesity is a state of subtle hypercortisolism accompanied by leptin and insulin resistance. Serum total cortisol concentration is normal or slightly subnormal in obese subjects. However, they have high cortisol production rates. Reduced
Patricio H. Contreras, Henrik Falhammar, Henrik Falhammar   +2 more
doaj   +1 more source

Amylin analogues as a novel perspective in anti‐obesity therapy

British Journal of Pharmacology, EarlyView.
Abstract Public health systems face a major challenge because of the worldwide obesity epidemic. The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively “lean” country, the numbers are alarmingly high and have reached almost 50% of the adult population.
Thomas A. Lutz
wiley   +1 more source

Leptin Resistance

Journal of the American College of Cardiology, 2008
Martin, Seth S., Qasim, Atif, Reilly, Muredach P.   +2 more
openaire   +1 more source

Dynamics of Apolipoprotein J Levels and Metabolic Parameters Following Bariatric Surgery

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Bariatric surgery has emerged as a potent intervention for ameliorating insulin resistance and its associated comorbidities in obese patients. Apolipoprotein J (ApoJ) and adiponectin are closely associated with insulin resistance and sensitivity, respectively.
Kellen Cristina da Cruz Rodrigues, Minjin Lee, Yejee Lim, Jennie Young, Brendon Chung, Susan Phillips, Theodore P. Ciaraldi, Young‐Bum Kim   +7 more
wiley   +1 more source