Results 151 to 160 of about 80,968 (287)

Homocysteine causes neuronal leptin resistance and endoplasmic reticulum stress. [PDF]

PLoS One, 2022
Preninka AI, Kuriya K, Yazawa K, Yoshii M, Yanase Y, Jockers R, Dam J, Hosoi T, Ozawa K.   +8 more
europepmc   +1 more source

Amylin analogues as a novel perspective in anti‐obesity therapy

British Journal of Pharmacology, EarlyView.
Abstract Public health systems face a major challenge because of the worldwide obesity epidemic. The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively “lean” country, the numbers are alarmingly high and have reached almost 50% of the adult population.
Thomas A. Lutz
wiley   +1 more source

Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance. [PDF]

Cell Metab, 2022
Loh K, Fukushima A, Zhang X, Galic S, Briggs D, Enriori PJ, Simonds S, Wiede F, Reichenbach A, Hauser C, Sims NA, Bence KK, Zhang S, Zhang ZY, Kahn BB, Neel BG, Andrews ZB, Cowley MA, Tiganis T.   +18 more
europepmc   +1 more source

Resting metabolic rate, plasma leptin concentrations, leptin receptor expression, and adipose tissue measured by whole-body magnetic resonance imaging in women with Prader-Willi syndrome

, 2002
Background: Obesity in Prader-Willi syndrome (PWS) may be related to abnormalities in the adipocyte-leptin-hypothalamic pathway and may be exacerbated by reductions in the resting metabolic rate (RMR).
Mohammad A Ghatei, Brynes, A.E., Thomas, E.L., Frost, G.S., Bloom, S.R., Goldstone, A.P., Gary Frost, Audrey E Brynes, Bell, J.D., E Louise Thomas, Stephen R Bloom, Jimmy D Bell, Anthony Holland, Anthony P Goldstone, Holland, A., Ghatei, M.A.   +15 more
core   +1 more source

Asthma and Multimorbidity Amongst Ethnic Minority Groups in High Income Countries

Clinical &Experimental Allergy, EarlyView.
There is a tight intersection between asthma, deprivation, ethnicity, multimorbidity and poor clinical outcomes. An integrated, holistic and culturally tailored approach is needed to improve clinical outcomes amongst ethnic minority groups with asthma and multimorbidity. ABSTRACT Asthma is one of the commonest noncommunicable diseases worldwide.
Mamidipudi Thirumala Krishna, Saibal Moitra, Anna Freeman, Ben Ainsworth, Rebecca Knibb, Ramesh Kurukulaaratchy, Adel H. Mansur   +6 more
wiley   +1 more source

Sulforaphane reduces obesity by reversing leptin resistance. [PDF]

Elife, 2022
Çakır I, Lining Pan P, Hadley CK, El-Gamal A, Fadel A, Elsayegh D, Mohamed O, Rizk NM, Ghamari-Langroudi M.   +8 more
europepmc   +1 more source

Leptin and hypertension in obesity

, 2006
Paco E Bravo1, Stephen Morse1, David M Borne2, Erwin A Aguilar1, Efrain Reisin11Sections of Nephrology and 2Comprehensive Medicine, Department of Internal Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, USAAbstract: Leptin ...
Efrain Reisin, Stephen Morse, David M Borne, Paco E Bravo, Erwin A Aguilar   +4 more
core  

Obesity in Classic Congenital Adrenal Hyperplasia: Mechanisms, Complications and Management

Clinical Endocrinology, EarlyView.
ABSTRACT Classic congenital adrenal hyperplasia (CCAH) is an autosomal recessive genetic disorder primarily caused by 21‐hydroxylase deficiency. Although the survival rate of patients has significantly improved with glucocorticoid replacement therapy, long‐term use of supraphysiological doses and multiple factors inherent to the disease itself have led
Jialin Mu, Yue Li, Meng Sun, Yulin Li, Panpan Li, Hui Zou   +5 more
wiley   +1 more source

Modeling leptin resistance in Drosophila melanogaster

, 2020
The adipose-derived hormone leptin is involved in regulating homeostatic function. When this satiety signal fails to suppress appetite, the phenomenon is referred to as leptin resistance, but mechanisms contributing to system failure remain unclear.
Butt, Maryam, Mansfield, Austin
core  

Effect of interdisciplinary obesity care on metabolic markers and body weight in people with type 2 diabetes in a rural setting: A randomised controlled trial

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Management of type 2 diabetes includes medications that can unintentionally increase obesity and insulin resistance. This unblinded, single‐centre, randomised controlled trial focused on rural Australian adults with type 2 diabetes (aged 18–75 and body mass index [BMI] >30 kg/m2), measuring the effectiveness of a tailored interdisciplinary ...
Giuliana O. Murfet, Iain K. Robertson, Sharon P. Luccisano, Michelle L. Kilpatrick   +3 more
wiley   +1 more source