Hippocampal Leptin Resistance and Cognitive Decline: Mechanisms, Therapeutic Strategies and Clinical Implications. [PDF]
BiomedicinesBackground: Leptin, an adipokine essential for regulating energy balance, exerts important effects on brain function, notably within the hippocampus, a region integral to learning and memory.
Valladolid-Acebes I.
europepmc +2 more sources
New pharmacological perspectives for the leptin receptor in the treatment of obesity [PDF]
Frontiers in Endocrinology, 2014 After its discovery in 1994, leptin became the great hope as an anti-obesity treatment based on its ability to reduce food intake and increase energy expenditure.
Clara eRoujeau +2 more
doaj +9 more sources
Removing melatonin receptor type 1 signaling leads to selective leptin resistance in the arcuate nucleus. [PDF]
J Pineal Res, 2019 Recent studies have highlighted the involvement of melatonin in the regulation of energy homeostasis. In this study, we report that mice lacking melatonin receptor 1 (MT1KO) gained more weight, had a higher cumulative food intake, and were more ...
Buonfiglio D +6 more
europepmc +2 more sources
Hyperleptinemia is required for the development of leptin resistance. [PDF]
PLoS ONE, 2010 Leptin regulates body weight by signaling to the brain the availability of energy stored as fat. This negative feedback loop becomes disrupted in most obese individuals, resulting in a state known as leptin resistance.
Zachary A Knight +3 more
doaj +6 more sources
The Phlorotannin-Rich Fraction of Ecklonia cava Extract Attenuated the Expressions of the Markers Related with Inflammation and Leptin Resistance in Adipose Tissue. [PDF]
Int J Endocrinol, 2020 Obesity is associated with systemic chronic inflammation, and it induces central leptin resistance which blocks the appetite-suppressing effect of leptin and leptin resistance in adipocytes. In the present study, we evaluated the effects of Ecklonia cava
Son M +7 more
europepmc +2 more sources
Sildenafil ameliorates leptin resistance and normalizes lipid handling in the hypothalamic and adipose tissues of testosterone-exposed pregnant rats. [PDF]
Heliyon, 2021 Leptin and hypothalamic-adipose lipid handling are relevant in determining the shift of metabolic activities. There are scanty findings connecting glucose dysregulation as a result of hyperandrogenism during gestation to hypothalamic-adipose axis and ...
Areola ED +9 more
europepmc +2 more sources
Melatonin Absence Leads to Long-Term Leptin Resistance and Overweight in Rats. [PDF]
Front Endocrinol (Lausanne), 2018 Melatonin (Mel), a molecule that conveys photoperiodic information to the organisms, is also involved in the regulation of energy homeostasis. Mechanisms of action of Mel in the energy balance remain unclear; herein we investigated how Mel regulates ...
Buonfiglio D +13 more
europepmc +2 more sources
Association between serum leptin concentrations and insulin resistance: a population-based study from China. [PDF]
PLoS ONE, 2013 BACKGROUND: Insulin resistance contributes to the cardio-metabolic risk. The effect of leptin in obese and overweight population on insulin resistance was seldom reported.
Hui Zuo +5 more
doaj +5 more sources
Cleavage of the leptin receptor by matrix metalloproteinase-2 promotes leptin resistance and obesity in mice. [PDF]
Sci Transl Med, 2018 Matrix metalloproteinase–2 inhibition rescued leptin receptor expression in the hypothalamus and reduced fat accumulation in rodent models of obesity.
Mazor R +9 more
europepmc +2 more sources
Leptin resistance and hippocampal behavioral deficits. [PDF]
Physiol Behav, 2017 The adipocyte-derived hormone leptin is an important regulator of body weight and metabolism through activation of brain leptin receptors expressed in regions such as the hypothalamus. Beyond these well described and characterized activities of leptin in the hypothalamus, it is becoming increasingly clear that the central activities of leptin extend to
Van Doorn C +3 more
europepmc +5 more sources