Results 11 to 20 of about 72,689 (297)
Phlorotannins from Ecklonia cava Attenuates Palmitate-Induced Endoplasmic Reticulum Stress and Leptin Resistance in Hypothalamic Neurons [PDF]
Marine Drugs, 2019 Leptin resistance in the hypothalamus has an essential role in obesity. Saturated fatty acids such as palmitate bind to Toll-like receptor 4 (TLR4) and lead to endoplasmic reticulum (ER) stress and leptin resistance.
Seyeon Oh +6 more
doaj +2 more sources
Selective leptin resistance revisited
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2013 In addition to effects on appetite and metabolism, leptin influences many neuroendocrine and physiological systems, including the sympathetic nervous system. Building on my Carl Ludwig Lecture of the American Physiological Society, I review the sympathetic and cardiovascular actions of leptin.
Allyn L. Mark
openalex +4 more sources
Leptin Resistance and the Neuro-Adipose Connection [PDF]
Frontiers in Endocrinology, 2017 This article was submitted to Cellular Endocrinology, a section of the journal Frontiers in Endocrinology.
Andreia Barateiro +2 more
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PATHOGENETIC MECHANISMS OF LEPTIN RESISTANCE
Российский кардиологический журнал, 2015 Leptin is a regulatory protein from adipokines family, that maintain energy homeostasis of the body and deter obesity development. Impaired transfer of leptin signals to hypothalamus leads to leptin resistance and its adverse complications. Understanding
G. A. Chumakova +4 more
doaj +3 more sources
MON-679 Study on the improvement of hypothalamic leptin resistance by SGLT2 inhibitors [PDF]
J Endocr SocJoo Yeon Kim +6 more
europepmc +3 more sources
MON-668 Leptin Resistance Alters Neuroplasticity-Linked Genes in Adult Hypothalamic Neurons [PDF]
J Endocr SocD Zieba +4 more
europepmc +3 more sources
MCBS (Molecular and Cellular Biomedical Sciences), 2021 Background: Leptin resistance which leads to excessive circulating leptin levels is thought to affect ovarian function. This study aimed to study the correlation between serum leptin levels with insulin resistance in patients with polycystic ovary ...
Arsyi Adliah Anwar +5 more
doaj +1 more source
Leptin signaling and leptin resistance [PDF]
Frontiers of Medicine, 2013 Leptin is secreted into the bloodstream by adipocytes and is required for the maintenance of energy homeostasis and body weight. Leptin deficiency or genetic defects in the components of the leptin signaling pathways cause obesity. Leptin controls energy balance and body weight mainly through leptin receptor b (LEPRb)-expressing neurons in the brain ...
Yingjiang, Zhou, Liangyou, Rui
openaire +2 more sources
Establishment of Leptin-Responsive Cell Lines from Adult Mouse Hypothalamus. [PDF]
PLoS ONE, 2016 Leptin resistance is considered to be the primary cause of obesity. However, the cause of leptin resistance remains incompletely understood, and there is currently no cure for the leptin-resistant state.
Hiroshi Iwakura +6 more
doaj +1 more source
The Leptin System and Diet: A Mini Review of the Current Evidence
Frontiers in Endocrinology, 2021 Leptin promotes satiety and modulates energy balance and weight. Diet-induced obesity leads to leptin resistance, exacerbating overeating. We reviewed the literature on the relationship between diet and leptin, which suggests that addressing leptin ...
Kenny Mendoza-Herrera +6 more
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