Results 231 to 240 of about 72,689 (297)
Obesity, Volume 34, Issue 2, Page 428-438, February 2026.ABSTRACT Objective Glucagon‐receptor (GCGR) agonism reguglates bile acid (BA) metabolism and promotes weight loss in diet‐induced obese (DIO) mice. Thus, we hypothesized that BA signaling contributes to GCGR‐stimulated weight loss. Methods To test this hypothesis, we utilized BA‐binding resins (BARs; colesevelam [Colsv] and cholestyramine [Cstyr]) to ...
Teayoun Kim +9 more
wiley +1 more source
Removing melatonin receptor type 1 signaling leads to selective leptin resistance in the arcuate nucleus. [PDF]
J Pineal Res, 2019 Buonfiglio D +6 more
europepmc +1 more source
Leptin resistance: a prediposing factor for diet-induced obesity
, 2008 Philip J. Scarpace, Yi Zhang
openalex +2 more sources
Targeted Next‐Generation Sequencing of the Leptin‐Melanocortin Pathway in Severe Obesity
Obesity, Volume 34, Issue 2, Page 499-511, February 2026.ABSTRACT Objective Pathogenic variants in five established leptin‐melanocortin pathway genes (LEP, LEPR, MC4R, PCSK1, POMC) are associated with severe early‐onset obesity and are targets for emerging treatments. However, these variants are rare in these patients, suggesting the involvement of additional genes interacting with this pathway. Methods Next‐
Nathan Faccioli +12 more
wiley +1 more source
Recent Insights Into Circulating Adipokines in Obesity: Systematic Review and Meta‐Analysis
Obesity Science &Practice, Volume 12, Issue 1, February 2026.ABSTRACT Background Adipokines are dysregulated in obesity and exacerbate proinflammatory conditions. Although several studies have investigated adipokine levels in obesity, their findings have been inconsistent, leaving the precise nature of these alterations uncertain.
Sunita Sunita +10 more
wiley +1 more source
Agrp-Specific Ablation of Scly Protects against Diet-Induced Obesity and Leptin Resistance. [PDF]
Nutrients, 2019 Torres DJ +3 more
europepmc +1 more source
Aging Cell, Volume 25, Issue 2, February 2026.This systematic review and meta‐analysis identifies blood‐based biomarkers (BBMs) reported in sarcopenia trials, investigating the impact of sarcopenia interventions on BBMs concentrations. Significant heterogeneity was observed in sarcopenia outcomes. Interventions had a limited impact on BBMs, except for IGF‐1, which was significantly impacted by the
Emma Calluy +10 more
wiley +1 more source
Clinical Obesity, Volume 16, Issue 1, February 2026.ABSTRACT Adiposity contributes to multiple non‐communicable diseases. To guide prevention of morbidity, this study aimed to quantify the relation between waist circumference (WC), body mass index (BMI), waist to height ratio (WtHR), abdominal subcutaneous (SAT) and visceral adipose tissue (VAT) and the risk of a composite outcome including recurrent ...
Ritobrata Bhattacharya +24 more
wiley +1 more source
Early overnutrition alters synaptic signaling and induces leptin resistance in arcuate proopiomelanocortin neurons. [PDF]
Physiol Behav, 2019 Roberts BL +4 more
europepmc +1 more source
A metabolic comparison of GIPR agonism versus GIPR antagonism in male mice
Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 1160-1167, February 2026.Abstract Aims Targeting the glucose dependent insulinotropic polypeptide receptor (GIPR) is of growing interest for treating type 2 diabetes and obesity, though the optimal approach remains unclear. Both GIPR agonism and antagonism, respectively, incorporated into drugs like tirzepatide and maridebart cafraglutide, have paradoxically both shown ...
Iona Davies +11 more
wiley +1 more source