Results 21 to 30 of about 3,112,452 (367)
The effect of resistance training and genistein on leptin and lipid profile of streptozotocin-induced diabetic rats [PDF]
Fiyz̤, 2018 Background: Diabetes is a chronic disease which can lead to increased levels of leptin and lipid profile. The aim of this study was to examine the effect of resistance training and genistein on leptin and lipid profile of streptozotocin-induced diabetic ...
Seyyed Ali Hosseini +4 more
doaj +2 more sources
Association of Leptin With Obesity and Insulin Resistance
Cureus, 2020 Introduction Leptin, a hormone released by the body to regulate energy balance by inhibiting hunger, decreases fat storage in adipocytes. Leptin is thought to play some role in obesity and insulin resistance.
Ratan Kumar +8 more
semanticscholar +4 more sources
Hypothalamic Leptin Resistance: From BBB to BBSome
PLOS Genetics, 2016 In 1969, Douglas Coleman joined the bodies of an obese and a normal mouse by a procedure called parabiosis. Days later, the normal mouse starved. Something had taken away its desire to eat [1].
Miguel López
semanticscholar +7 more sources
Acute leptin deficiency, leptin resistance, and the physiologic response to leptin withdrawal [PDF]
Proceedings of the National Academy of Sciences, 2005 Food restriction and weight loss result in reduced plasma leptin, which is associated with a pleiotropic biologic response. However, because weight loss itself is also associated with changes in numerous other humoral and metabolic signals, it can be difficult to determine the precise features of the biologic response to acute leptin deficiency.
Jason Montez +5 more
openalex +5 more sources
MCBS (Molecular and Cellular Biomedical Sciences), 2021 Background: Leptin resistance which leads to excessive circulating leptin levels is thought to affect ovarian function. This study aimed to study the correlation between serum leptin levels with insulin resistance in patients with polycystic ovary ...
Arsyi Adliah Anwar +5 more
doaj +1 more source
Leptin signaling and leptin resistance [PDF]
Frontiers of Medicine, 2013 Leptin is secreted into the bloodstream by adipocytes and is required for the maintenance of energy homeostasis and body weight. Leptin deficiency or genetic defects in the components of the leptin signaling pathways cause obesity. Leptin controls energy balance and body weight mainly through leptin receptor b (LEPRb)-expressing neurons in the brain ...
Liangyou Rui, Yingjiang Zhou
openaire +3 more sources
Leptin Resistance and Obesity [PDF]
Obesity, 2006 AbstractThe prevalence of obesity, and the human and economic costs of the disease, creates a need for better therapeutics and better understanding of the physiological processes that balance energy intake and energy expenditure. Leptin is the primary signal from energy stores and exerts negative feedback effects on energy intake.
Enriori, Pablo J +3 more
openaire +4 more sources
The Leptin System and Diet: A Mini Review of the Current Evidence
Frontiers in Endocrinology, 2021 Leptin promotes satiety and modulates energy balance and weight. Diet-induced obesity leads to leptin resistance, exacerbating overeating. We reviewed the literature on the relationship between diet and leptin, which suggests that addressing leptin ...
Kenny Mendoza-Herrera +6 more
doaj +1 more source
Leptin resensitisation: a reversion of leptin-resistant states [PDF]
Journal of Endocrinology, 2019 Leptin resistance refers to states in which leptin fails to promote its anticipated effects, frequently coexisting with hyperleptinaemia. Leptin resistance is closely associated with obesity and also observed in physiological situations such as pregnancy and in seasonal animals.
Maria Florencia Andreoli +5 more
openaire +5 more sources
A mathematical model of leptin resistance [PDF]
Mathematical Biosciences, 2015 Obesity is often associated with leptin resistance, which leads to a physiological system with high leptin concentration but unable to respond to leptin signals and to regulate food intake. We propose a mathematical model of the leptin-leptin receptors system, based on the assumption that leptin is a regulator of its own receptor activity, and ...
Jacquier, Marine +2 more
openaire +5 more sources