Results 21 to 30 of about 72,689 (297)
Hyperleptinemia is required for the development of leptin resistance. [PDF]
PLoS ONE, 2010 Leptin regulates body weight by signaling to the brain the availability of energy stored as fat. This negative feedback loop becomes disrupted in most obese individuals, resulting in a state known as leptin resistance.
Zachary A Knight +3 more
doaj +1 more source
Leptin Resistance and Obesity [PDF]
Obesity, 2006 AbstractThe prevalence of obesity, and the human and economic costs of the disease, creates a need for better therapeutics and better understanding of the physiological processes that balance energy intake and energy expenditure. Leptin is the primary signal from energy stores and exerts negative feedback effects on energy intake.
Enriori, Pablo J +3 more
openaire +3 more sources
Cholecystokinin (CCK) induces leptin resistance
Gastroenterology, 2000 Toshiharu Akiyama +4 more
openalex +2 more sources
Leptin resensitisation: a reversion of leptin-resistant states [PDF]
Journal of Endocrinology, 2019 Leptin resistance refers to states in which leptin fails to promote its anticipated effects, frequently coexisting with hyperleptinaemia. Leptin resistance is closely associated with obesity and also observed in physiological situations such as pregnancy and in seasonal animals.
Andreoli, Maria Florencia +3 more
openaire +4 more sources
Postnatal growth after intrauterine growth restriction alters central leptin signal and energy homeostasis. [PDF]
PLoS ONE, 2012 Intrauterine growth restriction (IUGR) is closely linked with metabolic diseases, appetite disorders and obesity at adulthood. Leptin, a major adipokine secreted by adipose tissue, circulates in direct proportion to body fat stores, enters the brain and ...
Bérengère Coupé +4 more
doaj +1 more source
Physiological leptin resistance [PDF]
Medycyna Weterynaryjna, 2016 Leptin is an adipose tissue-derived hormone whose circulating levels correlate with the amount of body fat stores. The main function of this adipokine is to regulate energy metabolism. By modulating the expression of orexigenic and anorexigenic neuropeptides in the hypothalamus, leptin reduces appetite.
Patrycja Gogga +3 more
openaire +1 more source
Concordance of bioactive vs. total immunoreactive serum leptin levels in children with severe early onset obesity. [PDF]
PLoS ONE, 2017 Leptin secreted from adipose tissue signals peripheral energy status to the brain. Monogenic leptin deficiency results in severe early onset obesity with hyperphagia.
Juraj Stanik +8 more
doaj +1 more source
Heliyon, 2022 Reducing the incidence of obesity is the focus of global attention, and traditional Chinese medicine (TCM) may play an important role in achieving this goal. Numerous studies have shown that most individuals with obesity have leptin resistance, exogenous
Jialin Shao +6 more
doaj +1 more source
Molecular Metabolism, 2018 Objective: The inability of leptin to suppress food intake in diet-induced obesity, sometimes referred to as leptin resistance, is associated with several distinct pathological hallmarks.
Maximilian Kleinert +5 more
doaj +1 more source
Journal of Lipid Research, 2008 Conjugated linoleic acid (CLA) induces insulin resistance preceded by rapid depletion of the adipokines leptin and adiponectin, increased inflammation, and hepatic steatosis in mice.
Angela A. Wendel +3 more
doaj +1 more source